Contents

Letters in Drug Design & Discovery, Volume 6 - Number 6

The Anticancer Activity of the N-Terminal CARD-Like Domain of Arginine Deiminase (ADI) from Pseudomonas aeruginosa

, 6(6): 403 - 412

Madhuchhanda Kundu, Johnson Thomas, Arsenio M. Fialho, Jennifer M. Kwan, Leonilde M. Moreira, Magdy Mahfouz, Tapas K. Das Gupta and Ananda M. Chakrabarty


DOI: 10.2174/157018009789057580




Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5]Bis-1,3-Azole Analogs of Bengazoles

, 6(6): 413 - 419

Laura Scarone, Jose Fajardo, Jenny Saldana, Laura Dominguez, Pablo Esposito, Sylvia Demastteis, Peter Wipf, Eduardo Manta and Gloria Serra


DOI: 10.2174/157018009789057553




The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor

, 6(6): 420 - 423

Yepeng Luan, Xuejian Wang, Huawei Zhu, Xianjun Qu, Hao Fang and Wenfang Xu


DOI: 10.2174/157018009789057535




Synthesis and Bioactivities of 2-Azetidinones as Cholesterol Absorption Inhibitors

, 6(6): 424 - 427

Jianfeng Ji, Rui Zhao, Wenlong Huang, Huibin Zhang, Jinpei Zhou, Yubin Wang and Hai Qian


DOI: 10.2174/157018009789057562




Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors

, 6(6): 428 - 436

Mahmud Tareq Hassan Khan and Ingebrigt Sylte


DOI: 10.2174/157018009789057607




Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice

, 6(6): 437 - 444

A. D. Cohen, M. D. Ikonomovic, E. E. Abrahamson, W. R. Paljug, S. T. DeKosky, I. M. Lefterov, R. P. Koldamova, L. Shao, M. L. Debnath, N. S. Mason, C. A. Mathis and W. E. Klunk


DOI: 10.2174/157018009789057526




Synthesis and Pharmacological Activity of Thiourea Derivatives of 1,7,8,9-Tetramethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

, 6(6): 445 - 450

Marta Struga, Jerzy Kossakowski, Anna E. Koziol, Tateusz Lis, Ewa Kedzierska and Sylwia Fidecka


DOI: 10.2174/157018009789057517




Synthesis, Spectral Studies and Anti-Bacterial Activity of Novel Substituted aryl/heteroaryl-(12-substituted phenyl-12H-7-oxa-8, 10-diazabenzo[ a]anthracen-11-yl)-amine

, 6(6): 451 - 455

K. A. Mahammed, K. N. Venugopala, P. N. Arunachalam and K. Mohana Raju


DOI: 10.2174/157018009789057616




Anticonvulsant Activity of A Novel Series of 2,5-Disubstituted 1,3,4-Oxadiazoles: Semicarbazones Based Pharmacophoric Model Studies

, 6(6): 456 - 463

Harish Rajak, Ravichandran Veerasamy, Pradeep Singour, Murli Dhar Kharya and Pradeep Mishra


DOI: 10.2174/157018009789057571




8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Aminobenzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities

, 6(6): 464 - 467

Tatyana M. Khomenko, Tatyana G. Tolstikova, Alexey V. Bolkunov, Margarita P. Dolgikh, Alla V. Pavlova, Dina V. Korchagina, Konstantin P. Volcho and Nariman F. Salakhutdinov


DOI: 10.2174/157018009789057544




Synthesis and Structure-Activity Relationship Study of 2-Substituted- 5-(5-nitro-2-thienyl)-1,3,4-thiadiazoles as Anti-Helicobacter pylori Agents

, 6(6): 468 - 474

Alireza Foroumadi, Somayeh Sedaghat, Saeed Emami, Maryam Yazdanian, Mohammad Hassan Moshafi, Maliheh Safavi, Amirhossein Sakhteman, Loghman Firoozpour, Mohsen Vosooghi and Abbas Shafiee


DOI: 10.2174/157018009789057599




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