Contents

Letters in Drug Design & Discovery, Volume 6 - Number 4





Synthesis of Substituted Pyrimidinedione Derivatives as Potential Schistosomicidal Agents

, 6(4): 268 - 277

Manal N.S. Saudi, Amal M. Youssef, Mona H. Badr, Rasha Y. Elbayaa, Mervat Z. El-azzouni, Shereen F. Mossallam, Nahed M. Baddour and Maha M. Eissa


DOI: 10.2174/157018009788452546




Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study

, 6(4): 298 - 303

Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Olga Cruz-Lopez, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini, Ernest Hamel, Enrica Fabbri and Roberto Gambari


DOI: 10.2174/157018009788452519



Use of Pre-Clinical In Vitro and In Vivo Pharmacokinetics for the Selection of a Potent Hepatitis C Virus Protease Inhibitor, Boceprevir, for Clinical Development

, 6(4): 312 - 318

K.-C. Cheng, Cheng Li, Tongtong Liu, Ganfeng Wang, Yunsheng Hsieh, Anastasia Pavlosky, Lisa Broske, Dan Prelusky, Rong Liu, Ronald E. White, Annette S. Uss, Samir Gupta and F. George Njoroge


DOI: 10.2174/157018009788452474



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