Letters in Drug Design & Discovery, Volume 6 - Number 4

Is DNA Minor Groove Binding Crucial for Biological Activity of Triazoloacridinones with Cytotoxic and Antitumour Properties?

, 6(4): 242 - 245

Marcin Koba, Katarzyna Koba and Tomasz Baczek

DOI: 10.2174/157018009788452465

DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents

, 6(4): 246 - 251

Roberto Dallocchio, Alessandro Dessi, Vanna Sanna, Nicolino Pala, Ilaria Campesi, Giuseppe Paglietti and Mario Sechi

DOI: 10.2174/157018009788452537

Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents

, 6(4): 252 - 257

Abha Bishnoi, Rashmi Saxena, Suruchi Singh, Archna Rani, M. N. Joshi and S. K. Bajpai

DOI: 10.2174/157018009788452500

Design, Synthesis and Preliminary Screening of Some New Conformationally Constrained Falcipain-2 Inhibitors as Potential Antimalarial Agents

, 6(4): 258 - 267

Anil K. Shinde, Bishram S. Chouhan, Shirshendu Dasgupta, Rajani Giridhar, Philip Rosenthal, Jiri Gut and Mange R. Yadav

DOI: 10.2174/157018009788452492

Synthesis of Substituted Pyrimidinedione Derivatives as Potential Schistosomicidal Agents

, 6(4): 268 - 277

Manal N.S. Saudi, Amal M. Youssef, Mona H. Badr, Rasha Y. Elbayaa, Mervat Z. El-azzouni, Shereen F. Mossallam, Nahed M. Baddour and Maha M. Eissa

DOI: 10.2174/157018009788452546

Combination of Time-Dependent and pH-Dependent System for Intestinal Delivery of 4-Aminosalicylic Acid Based Pellets

, 6(4): 278 - 285

Ibrahima Youm, Malika Lahiani-Skiba, Frederic Bounoure and Mohamed Skiba

DOI: 10.2174/157018009788452555

Comparative QSAR Studies on the Novel Series of Thiazolones and Tetrazole Derivatives as HCV NS5B Polymerase Allosteric Inhibitors

, 6(4): 286 - 297

Shalini Singh

DOI: 10.2174/157018009788452483

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study

, 6(4): 298 - 303

Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Olga Cruz-Lopez, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini, Ernest Hamel, Enrica Fabbri and Roberto Gambari

DOI: 10.2174/157018009788452519

Physicochemical and Pharmacological Characterization of Etodolac- Loaded Poloxamer Gel as a Rectal Delivery System

, 6(4): 304 - 311

Nahla S. Barakat and Hoda M. El-Maradny

DOI: 10.2174/157018009788452528

Use of Pre-Clinical In Vitro and In Vivo Pharmacokinetics for the Selection of a Potent Hepatitis C Virus Protease Inhibitor, Boceprevir, for Clinical Development

, 6(4): 312 - 318

K.-C. Cheng, Cheng Li, Tongtong Liu, Ganfeng Wang, Yunsheng Hsieh, Anastasia Pavlosky, Lisa Broske, Dan Prelusky, Rong Liu, Ronald E. White, Annette S. Uss, Samir Gupta and F. George Njoroge

DOI: 10.2174/157018009788452474

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