Contents

Letters in Drug Design & Discovery, Volume 4 - Number 2

Bortezomib: Proteasome Inhibition as a Novel Mechanism of Cancer Therapy-Implications for Hematological Malignancies

, 4(2): 82 - 86

Joesph Mikhael and Hong Chang


DOI: 10.2174/157018007779422541




Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies

, 4(2): 87 - 91

Andrew Tsotinis, Marilena Vlachou, Maria Gerasimopoulou, Aphrodite Eikosipentaki, Constantine Ioannidis, Anna Klouvidaki, Pandelis A. Afroudakis, Dimitri Moreau and Christos Roussakis


DOI: 10.2174/157018007779422488




Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells

, 4(2): 92 - 98

Chandrashekhar Chittimalla, Deniz Dalkara and Guy Zuber


DOI: 10.2174/157018007779422569




Fragment Based Approach for the Investigation of HIV-1 Integrase Inhibition

, 4(2): 99 - 105

J. Polanski, H. Niedbala, R. Musiol, B. Podeszwa, D. Tabak, A. Palka, A. Mencel, J.-F. Mouscadet and M. Le Bret


DOI: 10.2174/157018007779422532




Classical and Hologram QSAR Studies on a Series of Tacrine Derivatives as Butyrylcholinesterase Inhibitors

, 4(2): 106 - 113

M. S. Castilho, R. V. C. Guido and A. D. Andricopulo


DOI: 10.2174/157018007779422505




Synthesis and In Vitro Inhibitory Potential Towards Urease of 9-Anilinoacridines and Aciridinyl Hydrazides

, 4(2): 114 - 121

Khalid Mohammed Khan, Nosheen Akbar Rao, M. Arif Lodhi, Shahnaz Perveen, M. Iqbal Choudhary and Wolfgang Voelter


DOI: 10.2174/157018007779422523




Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study

, 4(2): 122 - 127

Magdalena Bacilieri, Chosei Kaseda, Giampiero Spalluto and Stefano Moro


DOI: 10.2174/157018007779422460




Non-Covalent Binding of Disodium Disuccinate Astaxanthin to the Catalytic Site of Phosphodiesterase 5A: A Molecular Modeling Study

, 4(2): 128 - 136

Eszter Hazai, Zsolt Bikadi, Ferenc Zsila and Samuel F. Lockwood


DOI: 10.2174/157018007779422497




Design and In Vitro Evaluation of Five Inhibitors of Mycobacterium Tuberculosis

, 4(2): 137 - 143

Ronald Bartzatt, Suat L. G. Cirillo and Jeffrey D. Cirillo


DOI: 10.2174/157018007779422451




Design, Synthesis and Biological Testing of Cyclohexenone Derivatives of Combretastatin-A4

, 4(2): 144 - 148

Jennifer Ruprich, Andrew Prout, John Dickson, Brent Younglove, Lawrence Nolan, Khyati Baxi, Regan LeBlanc, Lori Forrest, Patrice Hills, Herman Holt Jr, Hilary Mackay, Toni Brown, Susan L. Mooberry and Moses Lee


DOI: 10.2174/157018007779422442




Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions

, 4(2): 149 - 153

Mauro Vieira De Almeida, Marcus Vinicius de Nora Souza, Nadia Rezende Barbosa, Frederico Pittella Silva, Giovanni Wilson Amarante and Sílvia Helena Cardoso


DOI: 10.2174/157018007779422514




Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines

, 4(2): 154 - 159

Luiz Everson da Silva, Antonio Carlos Joussef, Leticia Kramer Pacheco, Danielle Bibas Legat Albino, Anita Mauricio Camilo Duarte, Mario Steindel and Ricardo Andrade Rebelo


DOI: 10.2174/157018007779422550




BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

, 4(2): 160 - 162

Roy Asaf, Shany Blum, Rachel Miller-Lotan and Andrew P. Levy


DOI: 10.2174/157018007779422479




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