Letters in Drug Design & Discovery, Volume 3 - Number 6

Targeting the Epidermal Growth Factor Receptor Family in Radionuclide Therapy of Tumors – Signal Transduction and DNA Repair

, 3(6): 357 - 368

Johan Lennartsson, Jorgen Carlsson and Bo Stenerlow

DOI: 10.2174/157018006777805503

MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore

, 3(6): 369 - 377

Carmen Avendano, Esmeralda Caballero, Cristina Mendez-Vidal, Ana R. de Quesada and J. Carlos Menendez

DOI: 10.2174/157018006777805558

Coenzyme Q10 and Neurological Diseases: An Update

, 3(6): 378 - 382

Michelangelo Mancuso, Anna Choub, Massimiliano Filosto, Lucia Petrozzi, Gianfranco Cafforio, Gabriele Siciliano and Luigi Murri

DOI: 10.2174/157018006777805495

Lead Optimisation: Improving the Affinity of the Antiretrovirals Nelfinavir and Amprenavir for HIV-1 Protease

, 3(6): 383 - 389

P. A. Fernandes, M.L. A.C. Araujo, A. J.M. Barbosa, C. N. Alves, Z. Q. Ferreira, C. R.-N. Gonzalez, C.F. R.A. C. Lima, S. I.E. Loureiro, J. M.T. Magalhaes, F. C. Maia, S. A. Moura, E.M. M. Peredo, M.A. S. Perez, T.A. Q. Rodrigues, A.M. Pessoa, C.A. M. da Silva, J.P. A. da Silva and M. J. Ramos

DOI: 10.2174/157018006777805576

Utilization of Ribozymes as Antiviral Agents

, 3(6): 390 - 404

M. L. Benitez-Hess and L. M. Alvarez-Salas

DOI: 10.2174/157018006777805521

Non-Classical Drug Metabolism Enzymes: The Curious Case of Phenylalanine 4-Monooxygenase

, 3(6): 405 - 412

G. B. Steventon and S. C. Mitchell

DOI: 10.2174/157018006777805512

High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

, 3(6): 413 - 418

O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro and A. Artese

DOI: 10.2174/157018006777805530

Antitubercular Properties of Substituted Hydroxycyclohexadienones

, 3(6): 419 - 423

Manish Shah, Geoffrey Wells, Tracey D. Bradshaw, Charles A. Laughton, Malcolm F.G. Stevens and Andrew D. Westwell

DOI: 10.2174/157018006777805486

Synthesis and In Vitro Anti-Tubercular Activity of a Series of N- (Disubstitutedbenzoyl)Isoniazid Derivatives

, 3(6): 424 - 428

Ivan Neves Junior, Maria C.S. Lourenco, Guilherme de B.P. de Miranda, Thatyana R.A. Vasconcelos, Karla C. Pais, Jose dos P. de A. Junior, M. S.V. Wardell, James L. Wardell and V. N. de Souza

DOI: 10.2174/157018006777805549

Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

, 3(6): 429 - 435

Vladimira Moulisova, Jiri Sebestian, Olga Jedlickova, Alexandr Jegorov and Stepanka B. Sebestianova

DOI: 10.2174/157018006777805567

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