Contents

Letters in Drug Design & Discovery, Volume 3 - Number 1

A 3D-QSAR of N-Substituted 4-Amino3-3-Dialkyl-2 (3H)-Furanone GABAA Receptor Modulators Based on Receptor Surface Analysis

, 3(1): 1 - 8

Savita Bhutoria, Prasenjit K. Mukherjee, Sandeep Chhabra and Nanda Ghoshal


DOI: 10.2174/157018006775240926




Preliminary Investigation of Structure-Activity Relationship of Cytotoxic Physalins

, 3(1): 9 - 13

H. I.F. Magalhaes, M. L. Veras, O. D.L. Pessoa, E. R. Silveira, M. O. Moraes, C. Pessoa and L. V. Costa-Lotufo


DOI: 10.2174/157018006775240917




C5,C6-Disubstituted 1H-Indole-2-Carboxamides: Synthesis and Cytotoxic Activity in the Human Non-Small Lung Cancer Cell Line NSCLC-N16-L16

, 3(1): 14 - 16

Andrew Tsotinis, Maria Gerasimopoulou, Margarita Vlachou, Dimitri Moreau and Christos Roussakis


DOI: 10.2174/157018006775240980




Computer-Assisted Analysis of the Interactions of Macrocyclic Inhibitors with wild Type and Mutant D168A Hepatitis C Virus NS3 Serine Protease

, 3(1): 17 - 28

Elaine F.F. da Cunha, Teodorico C. Ramalho, Carlton A. Taft and Ricardo B. de Alencastro


DOI: 10.2174/157018006775240953




Enhancement of Drug Cytotoxicity by Silicon Containing Groups

, 3(1): 29 - 34

Jose M. Padron, Osvaldo J. Donadel, Leticia G. Leon, Tomas Martin and Victor S. Martin


DOI: 10.2174/157018006775240944




Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products

, 3(1): 35 - 43

D. Sellanes, L. Scarone, G. Mahler, E. Manta, A. Baz, S. Dematteis, J. Saldana, L. Dominguez, P. Wipf and G. Serra


DOI: 10.2174/157018006775240962




Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities

, 3(1): 44 - 48

Sukumar Sakamuri, Quin-Zene Chen, Yingchun Lu, Yen-Fang Keng, Vladimir Khazak, Katrin Illgen, Silke Schabbert, Lutz Weber and Sanjay R. Menon


DOI: 10.2174/157018006775240890




Novel 5-HT7 Ligands as Antidepressants: Automated Synthesis of NSubstituted- N-[1-Methyl-3-(4-Methylpiperidin-1-yl)propyl]-Arylsulfonamides

, 3(1): 49 - 54

Eric Lattmann, Isidro Merino, Simon Dunn, Bushra Parveen, Pornthip Lattmann, David C. Billington, Yodchai Bunprakob and Jintana Sattayasai


DOI: 10.2174/157018006775240935




Evaluation of 2,3,4,8,13a Hexahydro-1H-Benzo[5,6]Cyclohepta-6,7- Dihydroxy[1,2,3-ef][3]Benzazepine Derivatives as Dopamine Receptor Ligands

, 3(1): 55 - 60

P. Sozio, F. Pinnen, A. Cocco, I. Cacciatore, G. Giorgioni, B. Costa, M. Montali, G. Spoto, F. Santoleri and Antonio Di Stefano


DOI: 10.2174/157018006775240971




Pyrrolo[3,4-c]Quinoline-1,3-Diones as Potent Caspase-3 Inhibitors: Synthesis and SAR of 8-Sulfamoyl-1,3-Dioxo-2,3-Dihydro-1H-Pyrrolo[3,4- c]Quinolines

, 3(1): 61 - 70

Dmitri V. Kravchenko, Julia A. Kuzovkova, Volodymyr M. Kysil, Sergey E. Tkachenko, Sergey Malarchuk, Ilya M. Okun and Alexandre V. Ivachtchenko


DOI: 10.2174/157018006775240908




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