Contents

Letters in Drug Design & Discovery, Volume 2 - Number 8

Rational Design of the New Antihypertensive I1-Receptor Ligand 2-(2- Biphenyl-2-yl-1-methyl-ethyl)-4,5-dihydro-1H-imidazole

, 2(8): 571 - 578

F. Gentili, P. Bousquet, A. Carrieri, J. Feldman, F. Ghelfi, M. Giannella, A. Piergentili, W. Quaglia, C. Vesprini and M. Pigini


DOI: 10.2174/157018005774717325




Docking Study, Synthesis and SAH-Hydrolase Inhibitory Activity of LAdeninylalanine and Related Analogues

, 2(8): 579 - 583

Nicolas Floquet, Samuel Leroy, Murielle Muzard, Georges Guillerm and Jean-Bernard Behr


DOI: 10.2174/157018005774717262




Anti-tumour Activity of Some Polydentate N-Ligands: N,N-bis-(3- Substituted-5-Methylpyrazol-1yl Methyl) Arylamines and N,N,N,N-Tetra- [(3-Substituted-5-Methylpyrazol-1yl] Para-Phenylenediamines

, 2(8): 584 - 589

T. B. Hadda, A. T. Kotchevar, M. Daoudi, B. Bennani, N. B. Larbi and A. Kerbal


DOI: 10.2174/157018005774717299




Discovery of Thrombin Inhibitor Fragments from Chemical Microarray Screening

, 2(8): 590 - 594

Thomas Neumann, Hans-Dieter Junker, Oliver Keil, Klaus Burkert, Holger Ottleben, Jurgen Gamer, Renate Sekul, Holger Deppe, Achim Feurer, Dirk Tomandl and Gunther Metz


DOI: 10.2174/157018005774717343




Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

, 2(8): 595 - 600

Nicolas Pietrancosta, Gilles Quelever, Cedrik Garino, Younes Laras, Stephane Burlet and Jean-Louis Kraus


DOI: 10.2174/157018005774717352




Synthesis and Biological Evaluation of 1,2,4-Triazolo[2,3-a]pyrrole Derivatives as Alpha-4 ( α4) Integrin Antagonists

, 2(8): 601 - 605

Edward C. Lawson, William A. Kinney, Rosemary J. Santulli, Carol M. Fisher, Bruce P. Damiano and Bruce E. Maryanoff


DOI: 10.2174/157018005774717280




Szeged Index - Applications for Drug Modeling&#

, 2(8): 606 - 624

Padmakar V. Khadikar, Sneha Karmarkar, Vijay K. Agrawal, Jyoti Singh, Anjali Shrivastava, Istvan Lukovits and Mircea V. Diudea


DOI: 10.2174/157018005774717334




Initial Structure-Activity Relationships for a Caprolactam-based Series of Neutral Factor Xa Inhibitors: Lead Identification

, 2(8): 625 - 630

Gregory S. Bisacchi, Philip D. Stein, Jack Z. Gougoutas, Karen S. Hartl, R. Michael Lawrence, Eddie Liu, Andrew Pudzianowski, William A. Schumacher, Doree Sitkoff, Thomas E. Steinbacher, James Sutton, Zhaoxiao Zhang and Steven M. Seiler


DOI: 10.2174/157018005774717316




Synthesis and Evaluation of p-Nitrophenylβ-D-Glucopyranosiduronic Analogues as New Triggers for β-Glucuronidase Mediated Prodrug Mono- Therapy

, 2(8): 631 - 637

Damien Combaud, Mickael Thomas, Sebastien Papot and Jean-Pierre Gesson


DOI: 10.2174/157018005774717271




Structure Based Design of Inhibitors of Aspartic Protease of HIV-1

, 2(8): 638 - 646

V. Frecer, A. Jedinak, A. Tossi, F. Berti, F. Benedetti, D. Romeo and S. Miertus


DOI: 10.2174/157018005774717307




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