Contents

Letters in Drug Design & Discovery, Volume 2 - Number 4

Graphical Abstracts

, 2(4): v - V


DOI: 10.2174/157018081050204000v




Cytostatic and Cytotoxic Activity of Synthetic Diterpene Derivatives Obtained from (-)-Kaur-9(11), 16-Dien-19-Oic Acid Against Human Cancer Cell Lines

, 2(4): 255 - 259

Randolph Alonso, Heidi Gomis, Antonieta Taddei and Cristina Sajo


DOI: 10.2174/1570180054038323




Synthesis and Properties of Two Antineoplastic Methanesulfonate Agents Utilizing Folic Acid and Triethanolamine

, 2(4): 260 - 265

R. L. Bartzatt


DOI: 10.2174/1570180054038468




Prostate-Apoptosis-Response-Gene-4: Biological Properties and their Potential Therapeutic Exploitation in Hematological Malignancies

, 2(4): 266 - 273

Simone Boehrer, Daniel Nowak, Dieter Hoelzer, Paris S. Mitrou and Kai Uwe Chow


DOI: 10.2174/1570180054038350




Targeting the G2/M Transition for Antitumor Therapy

, 2(4): 274 - 281

J. Yuan and K. Strebhardt


DOI: 10.2174/1570180054038378




Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase

, 2(4): 282 - 286

Enrique Angeles, Victor HugoVazquez-Valadez, Oscar Vazquez-Valadez, Ana Maria Velazquez-Sanchez, Alberto Ramirez, Luisa Martinez, Sandra Diaz-Barriga, Andres Romero-Rojas, Gustavo Cabrera, Rafael Lopez-Castanares and Alfonso Duenas-Gonzalez


DOI: 10.2174/1570180054038413




A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

, 2(4): 287 - 290

S. P. Gupta, Anitha Paleti, S. B. Mekapati, A. N. Nagappa and S. Kumaran


DOI: 10.2174/1570180054038422




Synthesis of a Spiro D-Proline Analogue Bearing D-Fructose

, 2(4): 291 - 293

Laura Cipolla, Cristina Redaelli and Francesco Nicotra


DOI: 10.2174/1570180054038369




Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

, 2(4): 294 - 301

Claudio Olea-Azar, Carolina Rigol, Fernando Mendizabal, Hugo Cerecetto, Rossanna Di Maio, Mercedes Gonzalez, Williams Porcal, Antonio Morello, Yolanda Repetto and Juan Diego Maya


DOI: 10.2174/1570180054038341




Development of Polyfluorophenyltropanes: Potential Probes for 19F Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) Assessments of the Dopamine Transporter

, 2(4): 302 - 306

Ao Zhang, Nora S. Kula, Kehong Zhang, Ross J. Baldessarini, Marc J. Kaufman, Perry F. Renshaw and John L. Neumeyer


DOI: 10.2174/1570180054038332




Synthesis of Azetidin-2-One Derivatives as Inhibitor of Secretory Phospholipase A2 with Anti-Inflammatory Activity

, 2(4): 307 - 310

Mayur C. Yerigeri, Satish Kumar Murari, Salahuddin Mohammed, Shanta Kumar Sugur Math, Kuntebommanahalli N. Thimmaiah and Bannikuppe Sannanaik Vishwanath


DOI: 10.2174/1570180054038404




Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases

, 2(4): 311 - 315

D. Reglodi, A. Tamas and A. Somogyvari-Vigh


DOI: 10.2174/1570180054038440




Cytoprotection by Melatonin, Precursors and Metabolites in an In Vitro Model of Neurotoxicity Induced by Okadaic Acid

, 2(4): 316 - 321

I. Tunez, R. Drucker-Colin, M. C. Munoz and P. Montilla


DOI: 10.2174/1570180054038396




Computational Characterization of a Series of Eicosanoids

, 2(4): 322 - 328

A. S.A. Gracon, S. J. Pernecky, M. C. Milletti, J.- A Park, Y. Yuan and H. Kim


DOI: 10.2174/1570180054038431




Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety †

, 2(4): 329 - 340

Manojit Pal, Venugopal Rao Veeramaneni, Sanjeev Kumar, Akhila Vangoori, Ramesh Mullangi, Parimal Misra, Shaikh Abdul Rajjak, Vidya B. Lohray, Seshagiri Rao Casturi and Koteswar Rao Yeleswarapu


DOI: 10.2174/1570180054038459




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