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Letters in Drug Design & Discovery

Volume 18, 12 Issues, 2021
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

Contents

Letters in Drug Design & Discovery, Volume 17 - Number 8



Review Article (Mini-Review)   Open Access

Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins

, 17(8): 943 - 953

Zhe Yin, Donglin Yang, Jun Wang and Yuequan Jiang*


DOI: 10.2174/1570180817666200213114759



Research Article

Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities

, 17(8): 954 - 964

Nuri Yildirim*


DOI: 10.2174/1570180817999200424073524



Research Article

Anticholinesterase Activity of Cinnamic Acids Derivatives: In Vitro, In Vivo Biological Evaluation, and Docking Study

, 17(8): 965 - 982

Shahrzad Ghafary, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Tahmineh Akbarzadeh, Mohammad Sharifzadeh, Najmeh Edraki, Farshad Homayouni Moghadam and Mohsen Amini*


DOI: 10.2174/1570180817666191224094049



Research Article

Biological Evaluation and Molecular Modeling of 3,4-dihydropyrimidine- 2(1H)-one Derivatives as Cytotoxic Agents on Breast Cancer In Vitro

, 17(8): 983 - 992

Hoda Sharifi, Ahmad Ebadi* and Meysam Soleimani*


DOI: 10.2174/1570180817666200203125010



Research Article

JAK/STAT3 Pathway in Human Intestinal Epithelial Cells During Trefoil Factor 3(TFF3) Mediated Cell Migration

, 17(8): 993 - 1000

Mengmeng Zhuang, Juan Le, Bo Zhu, Wenwen Zhang, Hao Yan, Pan Zhang, Ting Wang and Yong Sun*


DOI: 10.2174/1570180817666200204104420



Research Article

Rational Design of Hyper-glycosylated Human Chorionic Gonadotropin Analogs (A Bioinformatics Approach)

, 17(8): 1001 - 1014

Zahra Nabizadeh, Zarrin Minuchehr* and Ali Akbar Shabani*


DOI: 10.2174/1570180817666200225101938



Research Article

Synthesis, Docking, in silico ADMET and Pharmacological Evaluation of Some N-acetyl Pyrazole and Quinoline Conjugates

, 17(8): 1015 - 1026

Nargisbano Ayyub Peerzade, Shravan Yegu Jadhav*, Raghunath Bhikaji Bhosale, Amol Anantrao Kulkarni and Bhushan Dnyandeo Varpe


DOI: 10.2174/1570180817666200228123347



Research Article

Structure-based Virtual Screening Approach for the Discovery of Potent Inhibitors of Aminoglycoside 6'-N-Acetyltransferase Type Ib [AAC(6')-Ib] against K. pneumoniae Infections

, 17(8): 1027 - 1035

Reaz Uddin*, Bushra Siraj, Sidra Rafi, Syed Sikander Azam and Abdul Wadood


DOI: 10.2174/1570180817666200108095912



Research Article   Open Access

Studies on the IC50 of Metabolically Stable 1-(3,3-diphenylpropyl)- piperidinyl Amides and Ureas as Human CCR5 Receptor Antagonists Based on QSAR

, 17(8): 1036 - 1046

Yutao Zhao, Xiaoqian Liu, Jing Ouyang, Yan Wang, Shanyu Xu, Dongdong Tian and Hongzong Si*


DOI: 10.2174/1570180817666200320105725



Research Article

Synthesis, Characterization, Antimicrobial, Anti-tubercular, Antioxidant Activities and Docking Simulations of Derivatives of 2-(pyridin-3-yl)-1Hbenzo[ d]imidazole and 1,3,4-Oxadiazole Analogy

, 17(8): 1047 - 1059

Shipra Bhati, Vijay Kumar*, Simranjeet Singh and Joginder Singh*


DOI: 10.2174/1570180816666191122105313



Letter to the Editor   Open Access

Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells

, 17(8): 1060 - 1063

Parham Jabbarzadeh Kaboli * and King-Hwa Ling


DOI: 10.2174/1570180817666200212125658




Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)
Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Ivana Cacciatore serves as the Editor-in-Chief of the journal.

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