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Letters in Drug Design & Discovery

Volume 18, 12 Issues, 2021
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

Contents

Letters in Drug Design & Discovery, Volume 17 - Number 6


Research Article

Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury

, 17(6): 676 - 683

Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li*


DOI: 10.2174/1570180816666190731112158



Research Article

In Silico ADME and QSAR Studies on a Set of Coumarin Derivatives As Acetylcholinesterase Inhibitors Against Alzheimer’s Disease: CoMFA, CoMSIA, Topomer CoMFA, and HQSAR

, 17(6): 684 - 712

Uttam Ashok More*, Sameera Patel, Vidhi Rahevar, Malleshappa Ningappa Noolvi, Tejraj M. Aminabhavi and Shrinivas D. Joshi


DOI: 10.2174/1570180816666190712095907



Research Article

Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives

, 17(6): 713 - 724

Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*


DOI: 10.2174/1570180816666190710142848



Research Article

Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

, 17(6): 725 - 730

Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*


DOI: 10.2174/1570180816666190716141524



Research Article

Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character

, 17(6): 731 - 744

Csilla Sepsey Für, Gergö Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*


DOI: 10.2174/1570180816666190710130119



Research Article

Synthesis, Antibacterial Activity and Molecular Docking Studies of New Pyrazole Derivatives

, 17(6): 745 - 756

Adnan Cetin* and Havva Kurt


DOI: 10.2174/1570180816666190905155510



Research Article

Novel 3-Substituted-2, 3-Dihydro-2-Thioxoquinazolin-4-(1H)-one derivative as Anticonvulsants: Synthesis, Molecular Docking and Pharmacological Screening

, 17(6): 757 - 771

Nimisha jain and Pradeep Kumar Singour*


DOI: 10.2174/1570180816666191024090857



Research Article

Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure

, 17(6): 772 - 786

Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*


DOI: 10.2174/1570180816666190730163431



Research Article   Open Access

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *


DOI: 10.2174/1570180816666191024102231



Research Article

Design, Synthesis, and Anticancer Potential of the Enzyme (PARP-1) Inhibitor with Computational Studies of New Triazole, Thiazolidinone, - Thieno [2, 3-d] Pyrimidinones

, 17(6): 799 - 817

Ameen Ali Abu-Hashem*, Khadiga Mohamed Abu-Zied, Magdi Elsayed AbdelSalam Zaki, Mohamed Fathy El-Shehry , Hanem Mohamed Awad and Mohammed Abdou Khedr


DOI: 10.2174/1570180817666200117114716



Research Article

Insights into Biophysical Methods to Study Interactions Between HIV-1 Reverse Transcriptase and Non-nucleoside Reverse Transcriptase Inhibitors

, 17(6): 818 - 825

Julien Dumond, Jean-Marcel Julien Tronchet, Serge Kirkiacharian, Michel Seman and Michèle Reboud-Ravaux*


DOI: 10.2174/1570180816666190723121845




Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)
Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.

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