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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Contents

Letters in Drug Design & Discovery, Volume 17 - Number 6


Research Article

Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury

, 17(6): 676 - 683

Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li*


DOI: 10.2174/1570180816666190731112158



Research Article

In Silico ADME and QSAR Studies on a Set of Coumarin Derivatives As Acetylcholinesterase Inhibitors Against Alzheimer’s Disease: CoMFA, CoMSIA, Topomer CoMFA, and HQSAR

, 17(6): 684 - 712

Uttam Ashok More*, Sameera Patel, Vidhi Rahevar, Malleshappa Ningappa Noolvi, Tejraj M. Aminabhavi and Shrinivas D. Joshi


DOI: 10.2174/1570180816666190712095907



Research Article

Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives

, 17(6): 713 - 724

Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*


DOI: 10.2174/1570180816666190710142848



Research Article

Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

, 17(6): 725 - 730

Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*


DOI: 10.2174/1570180816666190716141524



Research Article

Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character

, 17(6): 731 - 744

Csilla Sepsey Für, Gergö Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*


DOI: 10.2174/1570180816666190710130119



Research Article

Synthesis, Antibacterial Activity and Molecular Docking Studies of New Pyrazole Derivatives

, 17(6): 745 - 756

Adnan Cetin* and Havva Kurt


DOI: 10.2174/1570180816666190905155510



Research Article

Novel 3-Substituted-2, 3-Dihydro-2-Thioxoquinazolin-4-(1H)-one derivative as Anticonvulsants: Synthesis, Molecular Docking and Pharmacological Screening

, 17(6): 757 - 771

Nimisha jain and Pradeep Kumar Singour*


DOI: 10.2174/1570180816666191024090857



Research Article

Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure

, 17(6): 772 - 786

Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*


DOI: 10.2174/1570180816666190730163431



Research Article   Open Access

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *


DOI: 10.2174/1570180816666191024102231



Research Article

Design, Synthesis, and Anticancer Potential of the Enzyme (PARP-1) Inhibitor with Computational Studies of New Triazole, Thiazolidinone, - Thieno [2, 3-d] Pyrimidinones

, 17(6): 799 - 817

Ameen Ali Abu-Hashem*, Khadiga Mohamed Abu-Zied, Magdi Elsayed AbdelSalam Zaki, Mohamed Fathy El-Shehry , Hanem Mohamed Awad and Mohammed Abdou Khedr


DOI: 10.2174/1570180817666200117114716



Research Article

Insights into Biophysical Methods to Study Interactions Between HIV-1 Reverse Transcriptase and Non-nucleoside Reverse Transcriptase Inhibitors

, 17(6): 818 - 825

Julien Dumond, Jean-Marcel Julien Tronchet, Serge Kirkiacharian, Michel Seman and Michèle Reboud-Ravaux*


DOI: 10.2174/1570180816666190723121845




Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.05

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