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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Contents

Letters in Drug Design & Discovery, Volume 16 - Number 8


Research Article

Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7- ones Derivatives as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors

, 16(8): 826 - 834

Ao Niu, Yang Wang, Yushe Yang*, Jianhai Wei, Jian Ding, Yi Chen, Linjiang Tong and Hua Xie


DOI: 10.2174/1570180815666180523090558



Research Article

Synthesis and Investigation on the Antidiabetic Effect of 3-aryl-1-(5methylisoxazol-3-ylamino)-1-(4-nitrophenyl) Propan-1-one

, 16(8): 835 - 845

Jinyu Liu, Zuwen Zhou, Jian Liu, Jufang Yan, Li Fan, Xuemei Tang, Jie Liu, Feifei Chen and Dacheng Yang*


DOI: 10.2174/1570180815666180608101529



Research Article

A One-pot Multicomponent ‘Click’ Approach to the Synthesis of Novel Tamoxifen-triazole Conjugates using Nano Iron Oxide Catalyst and their Preliminary Antiproliferative Activity Studies

, 16(8): 846 - 860

Mohana Rao Katiki*, Dileep Kommula, Sowjanya Polepalli, Nishant Jain and Madugula Sree Rama Murty*


DOI: 10.2174/1570180815666180621100314



Research Article

Identification of New Inhibitors of Mutant Isocitrate Dehydrogenase 2 through Molecular Similarity-based Virtual Screening

, 16(8): 861 - 867

Lijun Yang, Stefan Pusch, Victoria Jennings, Tianfang Ma, Qihua Zhu, Yungen Xu, Andreas von Deimling* and Xiaoming Zha*


DOI: 10.2174/1570180815666180808094432



Research Article

3D-QSAR Studies of S-DABO Derivatives as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

, 16(8): 868 - 881

Yueping Wang, Jie Chang, Jiangyuan Wang, Peng Zhong, Yufang Zhang, Christopher Cong Lai and Yanping He*


DOI: 10.2174/1570180815666180810112321



Research Article

Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

, 16(8): 882 - 891

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu


DOI: 10.2174/1570180815666180803124625



Research Article

Combined Virtual Screening, DFT Calculations and Molecular Dynamics Simulations to Discovery of Potent MMP-9 Inhibitors

, 16(8): 892 - 903

Hamed Bahrami*, Hafezeh Salehabadi, Zahra Nazari and Massoud Amanlou


DOI: 10.2174/1570180815666181008095950



Research Article

DNA Cleavage Properties, Antimicrobial and Cytotoxic Activity and 4D-QSAR Analysis of Some Pyrazole Derivatives

, 16(8): 904 - 918

Semiha Kopru, Fatma Ozturk Küp*, Nazmiye Sabanci, Mehmet Çadir, Duygu Cemre Bulut, Fatih Duman, Ilhan Ozer İlhan and Emin Saripinar*


DOI: 10.2174/1570180815666180926104319



Research Article

Investigation of Drug Interaction Potentials and Binding Modes on Direct Renin Inhibitors: A Computational Modeling Studies

, 16(8): 919 - 938

Lakshmanan Loganathan and Karthikeyan Muthusamy*


DOI: 10.2174/1570180815666180827113622



Research Article

Synthesis, Antioxidant and Antiurease Activities of Some New 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole Derivatives Containing Furan, Oxadiazole, Triazole and Thiadiazole Moieties

, 16(8): 939 - 947

Hakan Bektas*, Canan Albay, Emre Menteşe, Bahar Bilgin Sokmen, Zafer Kurt and Dilem Şen


DOI: 10.2174/1570180815666180827124956



Research Article   Open Access

In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration

, 16(8): 948 - 960

Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano C, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*


DOI: 10.2174/1570180816666190110112929



Research Article

Design, Synthesis, Biological Evaluation and In Silico Studies of Few Novel 2-Substituted Benzothiazole Derivatives as Potential EGFR Inhibitors

, 16(8): 961 - 971

Muhammad Mubeen, Suvarna Ganesh Kini*, Avinash Kumar and Karkala Sreedhara Ranganath Pai


DOI: 10.2174/1570180816666181108112228




Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.05

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