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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access
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    Chemistry, Medicinal

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Letters in Drug Design & Discovery, Volume 16 - Number 8

Research Article

Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7- ones Derivatives as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors

, 16(8): 826 - 834

Ao Niu, Yang Wang, Yushe Yang*, Jianhai Wei, Jian Ding, Yi Chen, Linjiang Tong and Hua Xie

DOI: 10.2174/1570180815666180523090558

Research Article

Synthesis and Investigation on the Antidiabetic Effect of 3-aryl-1-(5methylisoxazol-3-ylamino)-1-(4-nitrophenyl) Propan-1-one

, 16(8): 835 - 845

Jinyu Liu, Zuwen Zhou, Jian Liu, Jufang Yan, Li Fan, Xuemei Tang, Jie Liu, Feifei Chen and Dacheng Yang*

DOI: 10.2174/1570180815666180608101529

Research Article

A One-pot Multicomponent ‘Click’ Approach to the Synthesis of Novel Tamoxifen-triazole Conjugates using Nano Iron Oxide Catalyst and their Preliminary Antiproliferative Activity Studies

, 16(8): 846 - 860

Mohana Rao Katiki*, Dileep Kommula, Sowjanya Polepalli, Nishant Jain and Madugula Sree Rama Murty*

DOI: 10.2174/1570180815666180621100314

Research Article

Identification of New Inhibitors of Mutant Isocitrate Dehydrogenase 2 through Molecular Similarity-based Virtual Screening

, 16(8): 861 - 867

Lijun Yang, Stefan Pusch, Victoria Jennings, Tianfang Ma, Qihua Zhu, Yungen Xu, Andreas von Deimling* and Xiaoming Zha*

DOI: 10.2174/1570180815666180808094432

Research Article

3D-QSAR Studies of S-DABO Derivatives as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

, 16(8): 868 - 881

Yueping Wang, Jie Chang, Jiangyuan Wang, Peng Zhong, Yufang Zhang, Christopher Cong Lai and Yanping He*

DOI: 10.2174/1570180815666180810112321

Research Article

Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

, 16(8): 882 - 891

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu

DOI: 10.2174/1570180815666180803124625

Research Article

Combined Virtual Screening, DFT Calculations and Molecular Dynamics Simulations to Discovery of Potent MMP-9 Inhibitors

, 16(8): 892 - 903

Hamed Bahrami*, Hafezeh Salehabadi, Zahra Nazari and Massoud Amanlou

DOI: 10.2174/1570180815666181008095950

Research Article

DNA Cleavage Properties, Antimicrobial and Cytotoxic Activity and 4D-QSAR Analysis of Some Pyrazole Derivatives

, 16(8): 904 - 918

Semiha Kopru, Fatma Ozturk Küp*, Nazmiye Sabanci, Mehmet Çadir, Duygu Cemre Bulut, Fatih Duman, Ilhan Ozer İlhan and Emin Saripinar*

DOI: 10.2174/1570180815666180926104319

Research Article

Investigation of Drug Interaction Potentials and Binding Modes on Direct Renin Inhibitors: A Computational Modeling Studies

, 16(8): 919 - 938

Lakshmanan Loganathan and Karthikeyan Muthusamy*

DOI: 10.2174/1570180815666180827113622

Research Article

Synthesis, Antioxidant and Antiurease Activities of Some New 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole Derivatives Containing Furan, Oxadiazole, Triazole and Thiadiazole Moieties

, 16(8): 939 - 947

Hakan Bektas*, Canan Albay, Emre Menteşe, Bahar Bilgin Sokmen, Zafer Kurt and Dilem Şen

DOI: 10.2174/1570180815666180827124956

Research Article   Open Access

In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration

, 16(8): 948 - 960

Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano C, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*

DOI: 10.2174/1570180816666190110112929

Research Article

Design, Synthesis, Biological Evaluation and In Silico Studies of Few Novel 2-Substituted Benzothiazole Derivatives as Potential EGFR Inhibitors

, 16(8): 961 - 971

Muhammad Mubeen, Suvarna Ganesh Kini*, Avinash Kumar and Karkala Sreedhara Ranganath Pai

DOI: 10.2174/1570180816666181108112228


K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

Biography View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.05


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