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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Contents

Letters in Drug Design & Discovery, Volume 14 - Number 8


Research Article

A Two QSAR Way for Antidiabetic Agents Targeting Using α-Amylase and α-Glucosidase Inhibitors: Model Parameters Settings in Artificial Intelligence Techniques

, 14(8): 862 - 868

Karel Dieguez-Santana*, Hai Pham-The, Oscar M. Rivera-Borroto, Amilkar Puris, Huong Le-Thi-Thu and Gerardo M. Casanola-Martin*


DOI: 10.2174/1570180814666161128121142



Research Article

3D-QSAR, Topomer CoMFA, Docking Analysis, and ADMET Predictio n of Thioether Pleuromutilin Derivatives as Antibacterial Agents

, 14(8): 869 - 879

Zhen Wang, Zhi Wang and Li Ping Cheng*


DOI: 10.2174/1570180814666170111154331



Research Article

Copper Complexes of 8-Aminoquinoline and Uracils as Novel Aromatase Inhibitors

, 14(8): 880 - 884

Nujarin Sinthupoom, Veda Prachayasittikul, Ratchanok Pingaew, Apilak Worachartcheewan, Supaluk Prachayasittikul*, Somsak Ruchirawat and Virapong Prachayasittikul*


DOI: 10.2174/1570180813666161103144822



Research Article

3,4-Dihydropyrimidin-2(1H)-one C5 Amides as Inhibitors of T NFα Production: Synthesis, Biological Evaluation and Molecular Modeling

, 14(8): 885 - 897

Ahmad Ebadi, Mehdi Khoshneviszadeh, Katayoun Javidnia, Mohammad Hossein Ghahremani, Omidreza Firuzi* and Ramin Miri*


DOI: 10.2174/1570180814666170306120235



Research Article

Acetaminophen (Paracetamol) Facilitated Extinction Lear ning in Contextual Fear Conditioned Rats

, 14(8): 898 - 903

Neelam Zaman, Hammad Ahmad, Mobasher Ali Abid, Nisar-ur-Rahman, Talat Roome and Ghulam Abbas*


DOI: 10.2174/1570180814666170203162557



Research Article

Effects of Tetrahydroxystilbene Glucoside on Liver P450 Enzym e Expressions in Lipopolysaccharide-induced Dopamine Neuronal Dama ge Rats

, 14(8): 904 - 909

Guo-Qing Wang, Yan-Zhen Zhou, Jia-Wei Tian, Jing-Shan Shi, Jie Liu and Feng Zhang*


DOI: 10.2174/1570180814666161207125537



Research Article

New N’-Arylidene-2-[(4-Nitrophenyl)Piperazın-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation

, 14(8): 910 - 917

Leyla Yurttas*, Zafer A. Kaplancikli and Sennur Gorgulu-Kahyaoglu


DOI: 10.2174/1570180814666161207163450



Research Article

Novel Ferulic Acid-donepezil Hybrids as Multifunctional Agents for th e Treatment of Alzheimer’s Disease with Butyrylcholinesterase, Amyloid- β, Antioxidant and Neuroprotective Properties

, 14(8): 918 - 929

Tianping Li, Wanli Pan, Keren Wang, Wenmin Liu, Qianwen Ma and Zhipei Sang*


DOI: 10.2174/1570180814666170421181517



Research Article

Synthesis, Anti-inflammatory and Molecular Docking Study of Schiff Bases Containing Methanesulphonyl Pharmacophore

, 14(8): 930 - 937

Khaled R. A. Abdellatif*, Mohammed T. Elsaady, Salah A. Abdel-Aziz and Ahmed H. A. Abu Sabah


DOI: 10.2174/1570180814666161214163759



Research Article

Synthesis, Antibacterial, Antifungal, Antimycobacterial Activity Evaluation of Novel 1,2,4-triazole Derivatives Bearing 4-Aminophenyl Moiety

, 14(8): 938 - 948

Betul Kaya Cavusoglu, Leyla Yurttas, Meral Y. Cankilic and Zafer A. Kaplancikli


DOI: 10.2174/1570180814666161130103624



Research Article

Molecular Docking and Structure Activity Relationship Studies of NSAIDs. What do they Reveal about IC50?

, 14(8): 949 - 958

Chrysoula Mikra, Georgios Rossos, Sotirios K. Hadjikakou and Nikolaos Kourkoumelis*


DOI: 10.2174/1570180814666161207143231



Research Article

Molecular Docking, 3D-QSAR and Structural Optimization of Indole Biphenylcarboxylic Acids as PPARγ Antagonists

, 14(8): 959 - 973

Xin Liu, Yu-Ze Zhang, Zhi Jing, Wen-Qing Jia, Shu-Qing Wang, Wei-Ren Xu and Xian-Chao Cheng*


DOI: 10.2174/1570180814666161207130047



Review Article

Benzopentathiepine Derivative, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin- 6-Amine Hydrochloride (TC-2153), as a Promising Antidepressant of New Generation

, 14(8): 974 - 984

Elizabeth A. Kulikova, Konstantin P. Volcho*, Nariman F. Salakhutdinov and Alexander V. Kulikov


DOI: 10.2174/1570180814666161121112417




Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.05

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