Contents

Letters in Drug Design & Discovery, Volume 14 - Number 8

Biography

Meet Our Regional Editor

, 14(8): 861

John F. Honek


DOI: 10.2174/157018081408170720180649




Research Article

A Two QSAR Way for Antidiabetic Agents Targeting Using α-Amylase and α-Glucosidase Inhibitors: Model Parameters Settings in Artificial Intelligence Techniques

, 14(8): 862 - 868

Karel Dieguez-Santana, Hai Pham-The, Oscar M. Rivera-Borroto, Amilkar Puris, Huong Le-Thi-Thu and Gerardo M. Casanola-Martin


DOI: 10.2174/1570180814666161128121142





Research Article

3D-QSAR, Topomer CoMFA, Docking Analysis, and ADMET Predictio n of Thioether Pleuromutilin Derivatives as Antibacterial Agents

, 14(8): 869 - 879

Zhen Wang, Zhi Wang and Li Ping Cheng


DOI: 10.2174/1570180814666170111154331





Research Article

Copper Complexes of 8-Aminoquinoline and Uracils as Novel Aromatase Inhibitors

, 14(8): 880 - 884

Nujarin Sinthupoom, Veda Prachayasittikul, Ratchanok Pingaew, Apilak Worachartcheewan, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul


DOI: 10.2174/1570180813666161103144822





Research Article

3,4-Dihydropyrimidin-2(1H)-one C5 Amides as Inhibitors of T NFα Production: Synthesis, Biological Evaluation and Molecular Modeling

, 14(8): 885 - 897

Ahmad Ebadi, Mehdi Khoshneviszadeh, Katayoun Javidnia, Mohammad Hossein Ghahremani, Omidreza Firuzi and Ramin Miri


DOI: 10.2174/1570180814666170306120235





Research Article

Acetaminophen (Paracetamol) Facilitated Extinction Lear ning in Contextual Fear Conditioned Rats

, 14(8): 898 - 903

Neelam Zaman, Hammad Ahmad, Mobasher Ali Abid, Nisar-ur-Rahman, Talat Roome and Ghulam Abbas


DOI: 10.2174/1570180814666170203162557





Research Article

Effects of Tetrahydroxystilbene Glucoside on Liver P450 Enzym e Expressions in Lipopolysaccharide-induced Dopamine Neuronal Dama ge Rats

, 14(8): 904 - 909

Guo-Qing Wang, Yan-Zhen Zhou, Jia-Wei Tian, Jing-Shan Shi, Jie Liu and Feng Zhang


DOI: 10.2174/1570180814666161207125537





Research Article

New N’-Arylidene-2-[(4-Nitrophenyl)Piperazın-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation

, 14(8): 910 - 917

Leyla Yurttas, Zafer A. Kaplancikli and Sennur Gorgulu-Kahyaoglu


DOI: 10.2174/1570180814666161207163450





Research Article

Novel Ferulic Acid-donepezil Hybrids as Multifunctional Agents for th e Treatment of Alzheimer’s Disease with Butyrylcholinesterase, Amyloid- β, Antioxidant and Neuroprotective Properties

, 14(8): 918 - 929

Tianping Li, Wanli Pan, Keren Wang, Wenmin Liu, Qianwen Ma and Zhipei Sang


DOI: 10.2174/1570180814666170421181517





Research Article

Synthesis, Anti-inflammatory and Molecular Docking Study of Schiff Bases Containing Methanesulphonyl Pharmacophore

, 14(8): 930 - 937

Khaled R. A. Abdellatif, Mohammed T. Elsaady, Salah A. Abdel-Aziz and Ahmed H. A. Abu Sabah


DOI: 10.2174/1570180814666161214163759





Research Article

Synthesis, Antibacterial, Antifungal, Antimycobacterial Activity Evaluation of Novel 1,2,4-triazole Derivatives Bearing 4-Aminophenyl Moiety

, 14(8): 938 - 948

Betul Kaya Cavusoglu, Leyla Yurttas, Meral Y. Cankilic and Zafer A. Kaplancikli


DOI: 10.2174/1570180814666161130103624





Research Article

Molecular Docking and Structure Activity Relationship Studies of NSAIDs. What do they Reveal about IC50?

, 14(8): 949 - 958

Chrysoula Mikra, Georgios Rossos, Sotirios K. Hadjikakou and Nikolaos Kourkoumelis


DOI: 10.2174/1570180814666161207143231





Research Article

Molecular Docking, 3D-QSAR and Structural Optimization of Indole Biphenylcarboxylic Acids as PPARγ Antagonists

, 14(8): 959 - 973

Xin Liu, Yu-Ze Zhang, Zhi Jing, Wen-Qing Jia, Shu-Qing Wang, Wei-Ren Xu and Xian-Chao Cheng


DOI: 10.2174/1570180814666161207130047





Review Article

Benzopentathiepine Derivative, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin- 6-Amine Hydrochloride (TC-2153), as a Promising Antidepressant of New Generation

, 14(8): 974 - 984

Elizabeth A. Kulikova, Konstantin P. Volcho, Nariman F. Salakhutdinov and Alexander V. Kulikov


DOI: 10.2174/1570180814666161121112417





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