Contents

Letters in Drug Design & Discovery, Volume 13 - Number 9

Research Article

Structure-based Drugs Design Studies on Spleen Tyrosine Kinase Inhibitors

, 13(9): 845 - 858

Letícia Cristina Assis, Letícia Santos Garcia, Daiana Teixeira Mancini, Tamiris Maria Assis, Daniela Rodrigues Silva, Giovanna Gajo Cardoso, Alexandre Alves de Castro, Teodorico Castro Ramalho and Elaine Fontes Ferreira da Cunha


DOI: 10.2174/1570180813666160725095118



Research Article

In-silico Designing of Novel Camptothecin Analogues as Potent Inhibitors of Topoisomerase I: A Molecular Docking, QSAR, and ADME-T Study

, 13(9): 859 - 868

Darpan Raghav, Babukrishna Maniyadath, Aruna Mohan, Sutari Sairam, Rinu Mary Rajan and Krishnan Rathinasamy


DOI: 10.2174/1570180813666160518123550



Research Article

Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

, 13(9): 869 - 878

Rajnish Kumar, Pankaj Chauhan, Priyanka Malla, Manoj K. Mahapatra, Rolf W. Hartmann, Jörg Haupenthal and Manoj Kumar


DOI: 10.2174/1570180813666160630110649



Research Article

Identification of Novel IRAK-4 Inhibitors Through Pharmacophore Modeling, Atom-based 3D-QSAR, Docking Strategies and Molecular Dynamics Simulation

, 13(9): 879 - 887

Liangliang Zhong, Lu Zhou, Yahui Tian and Rong You


DOI: 10.2174/1570180813666160421163027



Research Article

Imidazole-based Derivatives as Potential Anti-platelet Inhibitors: DFT and Molecular Docking Study

, 13(9): 888 - 896

Mehbub I. K. Momin, Neil A. Koorbanally and Bahareh Honarparvar


DOI: 10.2174/1570180813666160517162937



Research Article

Synthesis and Antiacetylcholinesterase Activity Evaluation of New 2-aryl Benzofuran Derivatives

, 13(9): 897 - 902

Behjat Pouramiri, Mohammad Mahdavi, Setareh Moghimi, Loghman Firoozpour, Hamid Nadri, Alireza Moradi, Esmat Tavakolinejad-Kermani, Ali Asadipour and Alireza Foroumadi


DOI: 10.2174/1570180813666160610124637



Research Article

Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents

, 13(9): 903 - 911

Mehlika Dilek Altıntop, Ahmet Özdemir, Özlem Atlı, Zerrin Cantürk, Merve Baysal and Zafer Asım Kaplancıklı


DOI: 10.2174/1570180813666160226001021



Research Article

Synthesis and In vivo Antifibrotic Activity of Novel Leflunomide Analogues

, 13(9): 912 - 920

Abdelrahman Hamdi, Eman Said, Abdelbasset A. Farahat, Serry A. A. El-Bialy and Mohammed A. M. Massoud


DOI: 10.2174/1570180813666160630125624



Research Article

Synthesis and Antimicrobial Evaluation of New Pyrazoline and Pyrazolinyl Thiazole Derivatives Bearing Tetrazolo[1,5-a]quinoline Moiety

, 13(9): 921 - 931

Ibrahim A. M. Radini, Rizk E. Khidre and Emad M. El-Telbani


DOI: 10.2174/1570180813666160712234454



Research Article

Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives

, 13(9): 932 - 942

Jean Guillon, Stéphane Moreau, Luisa Ronga, Louise Basmacyian, Anita Cohen, Sandra Rubio, Guillaume Bentzinger, Solène Savrimoutou, Nadine Azas, Catherine Mullié and Pascal Sonnet


DOI: 10.2174/1570180813666160517164758



Research Article

Significance of Amino Group Substitution at Combretastatin A-4 and Phenstatin Analogs

, 13(9): 943 - 951

Vijay K. Patel and Harish Rajak


DOI: 10.2174/1570180813666160517163444



Research Article

Study of Some Piperine Analogues on Drugs Efflux by Targeting P-glycoprotein, an in silico Approach

, 13(9): 952 - 961

Anushree Tripathi, Krishna Misra and Rajesh Kumar Kesharwani


DOI: 10.2174/1570180813999160830102312



Research Article

Sodium Channel Blocking Activity and In-vivo Testing of New Phenylimidazole Derivatives

, 13(9): 962 - 967

Mirko Rivara, Manoj K. Patel, Alberto Rapalli and Valentina Zuliani


DOI: 10.2174/1570180813666160714125755



Research Article

An Efficient Nonconventional Glycerol-Based Solid Acid Catalyzed Synthesis and Biological Evaluation of Phosphonate Conjugates of 1,2,4-triazole Thiones

, 13(9): 968 - 981

Madugula S. R. Murty, Mohana R. Katiki, Busam R. Rao, Sai S. Narayanan, Ruby J. Anto, Sudhreer K. Buddana, Reddy S. Prakasham, Bethala L. A. P. Devi and Rachapudi B. N. Prasad


DOI: 10.2174/1570180813666160125222334



Research Article

Design, Synthesis and Molecular Docking Studies of 2-Aryl/Heteroaryl-Ethyl 6-Chloroquinoline-4-Carboxylates as Potential Antimalarial Agents

, 13(9): 982 - 991

Thamatakallu O. S. Kumar, Kittappa M. Mahadevan, Pasura S. Sujanganapathy and Manikyanahally N. Kumara


DOI: 10.2174/1570180813666160722112725




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