Contents

Letters in Drug Design & Discovery, Volume 13 - Number 1


Preface


Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade

, 13(1): 3 - 23

Andrea Roxanne J. Anas and Ken-ichi Harada


DOI: 10.2174/1570180812666150608230214



Development of Energy-based Pharmacophore Model and Stepwise Virtual Screening of LRRK2 Inhibitors Through Molecular Dynamics and Mechanics

, 13(1): 24 - 32

Sagar S. Bhayye, Kunal Roy and Achintya Saha


DOI: 10.2174/1570180812666150611185331



Studies on the IC50 of Trisubstituted Thiazoles as Cdc7 Kinase Inhibitors

, 13(1): 33 - 42

Huazhen Yang, Xun Liu, Zhiling Ye, Fucheng Song, Lianhua Cui, Zhuang Yu, Hongzong Si and Honglin Zhai


DOI: 10.2174/1570180812999150713144215



Molecular Simulation of HDAC1/3 Inhibitor: Insights into the Structural Basis of Selectivity

, 13(1): 43 - 46

Lei Zhang and Lihui Zhang


DOI: 10.2174/1570180812666150630183816



Recent Developments in the Synthesis and Applications of Anticancer Amonafide Derivatives. A Mini Review

, 13(1): 47 - 63

Gary Gellerman


DOI: 10.2174/1570180812666150529205049



A Series of 2,4(1H,3H)-Quinazolinedione Derivatives: Synthesis and Biological Evaluation as Potential Anticancer Agents

, 13(1): 64 - 76

Hulya Akgun, Demet Us Yilmaz, Rengul Cetin Atalay and Damla Gozen


DOI: 10.2174/1570180812666150529204909



Synthesis, Biological Evaluation and Molecular Docking Studies of 4Hbenzo[ h]chromenes, 7H-benzo[h]chromeno[2,3-d]pyrimidines as Antitumor Agents

, 13(1): 77 - 88

Ahmed H. Halawa, Ahmed M. Fouda, Al-Anood M. Al-Dies and Ahmed M. El-Agrody


DOI: 10.2174/1570180812666150611185830



Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2- Aryl-Quinoline Derivatives as Aromatase Inhibitors and Anti-breast Cancer Agents

, 13(1): 89 - 97

Razieh Ghodsi, Ebrahim Azizi, Maria Grazia Ferlin, Vincenzo Pezzi and Afshin Zarghi


DOI: 10.2174/1570180812666150611185605



Novel Aminopeptidase N Inhibitors with Improved Antitumor Activities

, 13(1): 98 - 106

Qiang Wang, Qiao Shi and Lu Huang


DOI: 10.2174/1570180812666150611190608



Biological Properties of Heterocyclic Pyridinylimines and Pyridinylhydrazones

, 13(1): 107 - 114

Francislene J. Martins, Rebeca Mol Lima, Juliana Alves dos Santos, Patricia de Almeida Machado, Elaine Soares Coimbra, Adilson David da Silva and Nádia Rezende Barbosa Raposo


DOI: 10.2174/1570180812666141216205601




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