Contents

Letters in Drug Design & Discovery, Volume 1 - Number 1

Preface

, 1(1): i

Atta-Ur-Rahman


DOI: 10.2174/1570180043485671




Discovery of Potent, Non-Steroidal and Highly Selective Glucocorticoid Receptor Antagonists with Anti-Obesity Activity

, 1(1): 1 - 5

Bradley P. Morgan, Kevin K.-C. Liu, Deepak K. Dalvie, Andrew G. Swick, Diane M. Hargrove, Theresa C. Wilson, Janet A. LaFlamme, Melinda S. Moynihan, Margaret A. Rushing and Graeme F. Woodworth


DOI: 10.2174/1570180043485734




Probing Proteinase Active Sites Using Oriented Peptide Mixture Libraries - ADAM-10

, 1(1): 6 - 13

John L. Krstenansky, Jihong Wang, Gregg R. Chenail, Matthew R. Tiffany, Geoffrey M. Kuesters, Barbara C. Natke, John J. Nestor and Jr.


DOI: 10.2174/1570180043485770




Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions

, 1(1): 14 - 18

Edward C. Lawson, William A. Kinney, Michael J. Costanzo, William J. Hoekstra, Jack A. Kauffman, Diane K. Luci, Rosemary Santulli, Brett A. Tounge, Stephen C. Yabut and Patricia Andrade-Gordon


DOI: 10.2174/1570180043485644




SAR and Molecular Modeling of N-Benzyl-N-hydroxy-3-(cyclopentyloxy)-4- methoxybenzene Carboxamide Analogues as Potent Phosphodiesterase-4 Inhibitors

, 1(1): 19 - 23

Jeewoo Lee, Su Yeon Kim, Hye Ra Lee and Je Hak Kim


DOI: 10.2174/1570180043485662




Fungal Metabolites as Potent Protein Kinase Inhibitors: Identification of a Novel Metabolite and Novel Activities of Known Metabolites

, 1(1): 24 - 29

Masayoshi Oyama, Zhihong Xu, Kuo-Hsiung Lee, Timothy D. Spitzer, Peter Kitrinos, Octerloney B. McDonald, Rosie R.J. Jones and Edward P. Garvey


DOI: 10.2174/1570180043485626




Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

, 1(1): 30 - 34

E. M.F. Muri, H. Mishra, S. M. Stein and J. S. Williamson


DOI: 10.2174/1570180043485680




Structure-Activity Relationship Determination Study of a Series of Novel Compounds as Potential Inhibitors of the Enzyme Estrone Sulfatase (ES)

, 1(1): 35 - 44

Chirag K. Patel, Caroline P. Owen, Kwabina Aidoo-Gyamfi and Sabbir Ahmed


DOI: 10.2174/1570180043485653




Thymidine Phosphorylase Over-Expression in Oral Squamous Carcinoma Tissue as a Potential Target of Capecitabine

, 1(1): 45 - 49

G. Ranieri, R. Patruno, G. Fiore, G. Saponaro, A. Paradiso and L. Grammatica


DOI: 10.2174/1570180043485725




Preclinical Evaluation of no-Carrier-Added [131I]Meta-Iodobenzyl Guanidine, for the Treatment of Tumours Transfected with the Noradrenaline Transporter Gene

, 1(1): 50 - 57

M. Boyd, S. Ross, J. Owens, D. Hunter, J. Babich, M. R. Zalutsky, T. G. Hamilton, S. Bell and R. J. Mairs


DOI: 10.2174/1570180043485743




Structure Activity Relationships for Nicotinamide in the Treatment of Stroke

, 1(1): 58 - 65

Jun Yang and James D. Adams Jr.


DOI: 10.2174/1570180043485716




Suppressive Components in Salvia miltiorrhiza Against Trp-P-1 and Activated Trp-P-1-Induced SOS Response Using Salmonella typhimurium TA1535 / pSK1002 Umu Test

, 1(1): 66 - 68

Yoshiharu Okuno and Mitsuo Miyazawa


DOI: 10.2174/1570180043485635




Synthesis and Cytotoxicity of Enediyne Prodrugs with 3-Hydroxy-4- (arylmethylidene)cyclodeca-1,5-diyne Scaffolds

, 1(1): 69 - 72

Wei-Min Dai, Yukihiro Tachi, Sei-ichi Nishimoto, Xiaofen Zhong and Zhihong Guo


DOI: 10.2174/1570180043485699




Expression of Peptide Transporters on the Rabbit Retina: A Strategy to Improve Retinal Delivery of Ganciclovir

, 1(1): 73 - 77

Soumyajit Majumdar, Sreeraj Macha, Yasser Nashed and Ashim K. Mitra


DOI: 10.2174/1570180043485707




Two Identical Twin Nitrogen Mustard Agents that Express Rapid Alkylation Activity at Physiological pH 7.4 and 37°C

, 1(1): 78 - 83

Ronald Bartzatt and Laura Donigan


DOI: 10.2174/1570180043485789




Somatostatin Receptor Subtype 4 (sst4) Ligands: Synthesis and Evaluation of Indol-3-yl- and 2-Pyridyl-Thioureas

, 1(1): 84 - 87

A. M. Crider, S. Liu, T. Li, S. Mahajan, M. Ankersen and C. E. Stidsen


DOI: 10.2174/1570180043485761




Polycations. 15. Polyammonium Surfaces - A New Approach to Antifungal Activity

, 1(1): 88 - 90

J. I. Cohen, T. Abel, D. Burkett, R. Engel, J. Escalera, M. Filshtinskaya, T. Hatchett, M. Leto, Y. Melgar and K. Melkonian


DOI: 10.2174/1570180043485752




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