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Letters in Drug Design & Discovery

Volume 16, 12 Issues, 2019
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

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  • 57th of 61 in

    Chemistry, Medicinal

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New Hydrazone Derivatives of Pyrazole-4-carboxaldehydes Exhibited Anti-inflammatory Properties


Mingxia Song, Xianqing Deng*, Bing Liu, Shengwang Yu, Shihui He, Yuqiu Liang, Sifan Li and Qiuyan Chen


DOI: 10.2174/1570180816666190731113441
View Abstract



Synthesis, In Silico and In Vivo Evaluation of Novel 1, 3, 4-Thiadiazole Analogues as Novel Anticancer Agents


Byran Gowramma*, Swathi Krishna, Manal Mohammed, Thaggikuppe K Praveen, Rajagopal Kalirajan and L Kaviarasan


DOI: 10.2174/1570180816666190710145939
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Microwave-assisted Synthesis and Docking Studies of Phenylureas as Candidates for the Drug Design Against the Biological Warfare Agent Yersinia Pestis


Tanos Celmar Costa França*, Leonardo da Costa Bastos, Teobaldo Cuya, Mehdi Sirouspour, Franklin Chacón-Huete, David Bendahan and Pat Forgione


DOI: 10.2174/1570180816666190710144212
View Abstract


Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character


Csilla Sepsey Für, Gergő Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*


DOI: 10.2174/1570180816666190710130119
View Abstract


Melatonin Ameliorates Radiation-induced Sciatic Nerve Injury


Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Mansoor Keshavarz, Gholamreza Hassanzadeh, Mohammed Reza Hadian, Azin Nowrouzi, Alireza Shirazi* and Masoud Najafi


DOI: 10.2174/1570180816666190617160434
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Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities


Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*


DOI: 10.2174/1570180816666190716141524
View Abstract



Cytotoxic Activity and DNA Binding Property of New Aminopyrimidine Derivatives


Hamidreza Akrami, Bibi Fatemeh Mirjalili, Omidreza Firuzi, Azadeh Hekmat, Ali Akbar Saboury, Ramin Miri, Omid Sabzevari, Morteza Pirali-Hamedani, Fereshteh Jeivad, Setareh Moghimi, Saeed Emami, Alireza Foroumadi* and Mehdi Khoobi*


DOI: 10.2174/1570180816666190712102119
View Abstract


Synthesis and Evaluation of Anticonvulsant Activities of 4- Phenylpiperidin-2-one Derivatives


Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*


DOI: 10.2174/1570180816666190710142848
View Abstract


Azacyanines as Novel Topoisomerase II Alpha Inhibitors


Sercan Guloglu, Fahriye Nur Kirmaci, Ozgul Persil Cetinkol*, Mehrdad Forough and Aybuke Gulkaya


DOI: 10.2174/1570180816666190628161945
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Diversified Thiazole Substituted Coumarins and Chromones as Non- Cytotoxic ROS and NO Inhibitors


Uzma Salar, Khalid Mohammed Khan*, Almas Jabeen, Shafquat Hussain, Aisha Faheem, Farwa Naqvi and Shahnaz Perveen


DOI: 10.2174/1570180816666190611155218
View Abstract





In vitro and In Vivo Evaluation of Quinoxaline 1,4-di-N-oxide Against Giardia lamblia


Elizabeth Barboza-Cabrera, Rosa Moo-Puc, Antonio Monge, Alma D. Paz-Gonzalez, Virgilio Bocanegra-Garc and Gildardo Rivera*


DOI: 10.2174/1570180816666190618115854
View Abstract



Evaluating Radioprotection of Rat’s Jejunum by A Combination of Melatonin and Metformin


Nasim Ahmadi Azar, Abdolreza Javadi, Masoud Najafi*, Alireza Shirazi*, Elham Tajabadi, Dheyauldeen Shabeeb and Ahmed Eleojo Musa


DOI: 10.2174/1570180816666190617153004
View Abstract


Synthesis of Piperidine Conjugated Dihydroquinazolin-4(1H)-ones and their Antiproliferative Activity, Molecular Docking Studies and DFT Calculations


Kereyagalahally H. Narasimhamurthy, Chandra, Toreshettahally R. Swaroop, Swamy Jagadish and Kanchugarakoppal S. Rangappa*


DOI: 10.2174/1570180816666190613120349
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Antiglycation Activity of N, N-Diethylthiobarbiturates Derivatives


Momin Khan*, Ghulam Ahad, Ajmal Khan, Uzma Salar, Sana Shah, Syed Muhammad Salman, Kanwal, Syed Muhammad Salman and Khalid Mohammed Khan*


DOI: 10.2174/1570180816666190516111516
View Abstract


Synthesis of New 4-Chloro-6-Methylpyrimidin-2-yl-Aminophosphonates as Potential DU145 and A549 Cancer Cell Inhibitors


Gajjala Raghavendra Reddy, Chinta Raveendra Reddy, Gopireddy Venkata Subba Reddy, Pasupuleti Visweswara Rao, Meenakshisundaram Swaminathan and Cirandur Suresh Reddy*


DOI: 10.2174/1570180816666190329223207
View Abstract



Synthesis And Herbicidal ActivitiesOf Novel Thiazole PPO Inhibitors


Guihua Ren, Dan Pei, Fan Zhang, Jie Liu, Shu Chen, Donglin Zhang, Ren Yang, Jianjun Shi, Tianming Xu and Chengxia Tan*


DOI: 10.2174/1570180816666190329221521
View Abstract


Studies on the pIC50 of 4,5-Diarylisoxazole as HSP90 Inhibitors


Jing Ouyang, Xiaoqian Liu, Yutao Zhao, Ying Liu, Hongzong Si* and Honglin Zhai


DOI: 10.2174/1570180816666190329221959
View Abstract


3D-QSAR and Docking Studies on Pyrimidine Derivatives as CSF-1R inhibitors


Ya-ting Deng, Jun-wei Wang, Han Chu, Juan Wang, Yong Hu, Yong lin, Mao Shu and Zhi-hua Lin*


DOI: 10.2174/1570180816666190329224946
View Abstract


An Efficient Protocol for the Synthesis, Biological Screening and Molecular Docking Studies of 3,4-Dihydropyrimidine-2-one/thione Derivatives


Ehsan Ullah Mughal*, Hafiz Umar Farooq, Amina Sadiq, Hummera Rafique, Sajjad Hussain Sumrra, Muhammad Naveed Zafar, Nighat Fatima, Syed Aun Muhammad, Abdul Manan, Chaudhary Omer Javed and Muhammad Tayyab


DOI: 10.2174/1570180816666190329224458
View Abstract


Drug Discovery of Acetophenone Derivatives as BRD4 Inhibitors


Zhimin Zhang, Wenhai Huang, Xiaoliang Zheng, Chuansheng Li and Zhengrong Shen*


DOI: 10.2174/1570180816666190329223559
View Abstract



A Series of Furan-Based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity


Mehlika Dilek Altıntop*, Belgin Sever, Özlem Atlı Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir


DOI: 10.2174/1570180816666190325163948
View Abstract


Novel Strobilurin Derivatives Containing Carboxylate Unit as Potential Antifungal Agents


Longzhu Bao, Shuangshuang Wang, Di Song, Jingjing Wang, Xiali Yue and Xiufang Cao*


DOI: 10.2174/1570180816666190325164452
View Abstract



Anti-trypanosoma Cruzi Activity and Molecular Docking Studies of 1Hpyrazolo[ 3, 4-b]Pyridine Derivatives


Camilo Henrique da Silva Lima, Júlio César de Araújo Vanelis Soares, Joana Lucius de Sousa Ribeiro, Estela Maris Freitas Muri, Sérgio de Albuquerque and Luiza Rosaria Sousa Dias*


DOI: 10.2174/1570180816666190305141733
View Abstract







Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties


Chengshu Jia, Bin Hu, Yingying Ji, Yourui Su, Guoqing Gong*, Qihua Zhu and Yungen Xu*


DOI: 10.2174/1570180816666181113102359
View Abstract



Synthesis and Analgesic Activity of Monoterpenoid Aldehyde-Derived Hydro-2H-chromeneols


Irina V. Il`ina*, Ekaterina A. Morozova*, Dina V. Korсhagina, Konstantin P. Volcho, Tat`yana G. Tolstikova and Nariman F. Salakhutdinov


DOI: 10.2174/1570180816666181114131220
View Abstract


Synthesis, Antiproliferative, and Antioxidant Activities of Substituted N-[(1,3,4-Oxadiazol-2-Yl) Methyl] Benzamines


Mohamed Jawed Ahsan, Lakshya Bhandari, Shally Makkar, Rajan Singh, Mohd. Zaheen Hassan, Mohammed H. Geesi, Mohammed Afroz Bakht, Surender Singh Jadav, Tuniki Balaraju, Yassine Riadi , Sandhya Rani, Habibullah Khalilullah, Vasubabu Gorantla and Afzal Hussain


DOI: 10.2174/1570180816666181113110033
View Abstract




Synthesis and SAR Study of Simple Aryl Oximes and Nitrofuranyl Derivatives with Potent Activity Against Mycobacterium Tuberculosis


Cristiane França da Costa, Marcus Vinicius Nora de Souza*, Maria Cristina da Silva Lourenço, Elaine Soares Coimbra, Guilherme da Silva Lourenço Carvalho, James Wardell, Stephane Lima Calixto and Juliana da Trindade Granato


DOI: 10.2174/1570180816666181227115738
View Abstract


Synthesis and Antimicrobial Activity of Thiohydantoins Obtained from L-Amino Acids


Priscila Goes Camargo de Carvalho, Jhonatan Macedo Ribeiro, Renata Perugini Biasi Garbin, Gerson Nakazato, Sueli F. Yamada- Ogatta, Ângelo de Fátima, Marcelle L. F. Bispo and Fernando Macedo Jr*


DOI: 10.2174/1570180816666181212153011
View Abstract



Synthesis and In vitro Biological Activity Evaluation of Novel Imidazo [2,1-B][1,3,4] Thiadiazole as Anti-alzheimer Agents


Sara Azimi, Omidreza Firuzi, Aida Iraji, Afsaneh Zonouzi , Mahsima Khoshneviszadeh, Mohammad Mahdavi* and Najmeh Edraki*


DOI: 10.2174/1570180816666181108115510
View Abstract


Antimicrobial Activity, Antioxidant Properties and Phytochemical Screening of Aesculus Hippocastanum Mother Tincture against Food-Borne Bacteria


Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso* and Giovanni Salzano


DOI: 10.2174/1570180816666181108114115
View Abstract


New Hybrids Derived from the Natural Compound (-)-Β-Pinene and Amides or Acylthioureas as Antitumor Agents


Shengliang Liao, Xiaoping Rao, Minggui Shen, Hongyan Si, Jie Song, Shibin Shang* and Zhanqian Song*


DOI: 10.2174/1570180816666181107094427
View Abstract




An Environment-Friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation


Sanal Dev, Della Grace Thomas Parambi, Benncy Baby, Githa Elizabeth Mathew, Hendawy OM, Monu Joy, Shine Sudev and Bijo Mathew*


DOI: 10.2174/1570180815666181016155934
View Abstract






Caffeic Acid Phenethyl Ester Effects: In Silico Study of its Osteoimmunological Mechanisms


Ghulam Murtaza*, Yuhao Zhao, Xiaokun Pang, Xiaoxin Xu, Xincan Jiang, Dongbin Zhao, Yanxu Ma and Akriti Nepal


DOI: 10.2174/1570180815666180803111902
View Abstract





Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

Biography View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
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