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Letters in Drug Design & Discovery

Volume 18, 12 Issues, 2021
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of the latest Internet technology for both the submission and review of manuscripts. The journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

,

Volume 18

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Number 4



Biography   Open Access



Review Article (Mini-Review)







Research Article









Articles Ahead of Print




Synthesis of Chrysin, Quercetin and Naringin Nitroderivatives: Antiproliferative, Anti-Inflammatory and Antioxidant Activity


Rosario Tavera-Hernández, Manuel Jiménez-Estrada*, Jesús J. Alvarado-Sansininea, Antonio Nieto-Camacho, Hugo López-Muñoz, Luis Sánchez-Sánchez and María L. Escobar


DOI: 10.2174/1570180818666210122162313
View Abstract



In-Silico Study to Identify Dietary Molecules as Potential SARS-CoV-2 Agents


Mohammad Faheem Khan*, Mohsin Ali Khan, Zaw Ali Khan, Tanveer Ahamad and Waseem Ahmad Ansari


DOI: 10.2174/1570180817999201209204153
View Abstract




Mode Action Prediction of Butein as Antibacterial Oral Pathogen against Enterococcus faecalis ATCC 29212 and an Inhibitor of MurA Enzyme: In Vitro and In Silico Study


Mieke Hemiawati Satari*, Ameta Primasari, Hendra Dian Adhita Dharsono, Eti Apriyanti, Maria Matoetina Suprijono, Yetty Herdiyati and Dikdik Kurnia*


DOI: 10.2174/1570180818666210122163009
View Abstract


Modifications of Isoalantolactone Leading to Effective Anti-bacterial and Anti-viral Compounds


Sergey S. Patrushev, Lyubov G. Burova, Anna A. Shtro, Tatyana V. Rybalova, Dmitry S. Baev, Il’ya V. Shirokikh, Alexander N. Evstropov and Elvira E. Shults*


DOI: 10.2174/1570180817999201211193151
View Abstract


Abstracts Ahead of Print



Antioxidant and ROS inhibitory activities of heterocyclic 2-Aryl-4(3H)-quinazolinone derivatives


Shahida Perveen*, Syed Muhammad Saad, Khalid Mohammed Khan and Muhammad Iqbal Choudhary


DOI: 10.2174/1570180818666210427092319
View Abstract






In silico drug design: development of new pyrimidine-based benzo-thiazole derivatives, selective for CDK2


Rania Kasmi*, Larbi Elmchichi, Abdellah El Aissouq, Mohammed Bouachrine and Abdelkrim Ouammou


DOI: 10.2174/1570180818666210421134819
View Abstract




Published Contents

Editor's Choice


Expanding Opportunities in Treatment of Leukemia by Solid Lipid Nanoparticles

, 2021; 18(3): 212 - 221

Prarthna Yadav, Harshita Mishra, Manju Nagpal and Geeta Aggarwal*


DOI: 10.2174/1570180817999201001155508



Sulfonamides and Sulphonyl Ester of Quinolines as Non-Acidic, Non- Steroidal, Anti-inflammatory Agents

, 2021; 18(2): 112 - 120

Bilquees Bano, Kanwal, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Muhammad Taha, Syed Moazzam Haider and Shahnaz Perveen


DOI: 10.2174/1570180817999201005201308




Novel Coronavirus 2019 Outbreak: A Global Epidemic

, 2020; 17(12): 1458 - 1464

Sweta Kamboj*, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Rohit Dutt


DOI: 10.2174/1570180817999200802033916



Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach

, 2020; 17(11): 1401 - 1408

Pooja Siniprasad, Bhagyalakshmi Nair, Vaisali Balasubramaniam, Prashanth Sadanandan, Puliyapally Krishnan Namboori* and Lekshmi Reghu Nath*


DOI: 10.2174/1570180817999200623115703



Anti-inflammatory Augmentation Therapy in Obsessive-compulsive Disorder: A Review

, 2020; 17(10): 1198 - 1205

Hanie Ghasemi, Homa Nomani, Amirhossein Sahebkar* and Amir Hooshang Mohammadpour*


DOI: 10.2174/1570180817999200520122910






Open Access Articles




Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *




Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure

, 2020; 17(6): 772 - 786

Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*




Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

, 2020; 17(6): 725 - 730

Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*




Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives

, 2020; 17(6): 713 - 724

Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*




Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury

, 2020; 17(6): 676 - 683

Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li*




Azacyanines as Novel Topoisomerase II Alpha Inhibitors

, 2020; 17(5): 666 - 671

Sercan Guloglu, Fahriye Nur Kirmaci, Özgül Persil Çetinkol*, Mehrdad Forough and Aybuke Gulkaya




Microwave-assisted Synthesis and Docking Studies of Phenylureas as Candidates for the Drug Design Against the Biological Warfare Agent Yersinia Pestis

, 2020; 17(5): 633 - 639

Tanos Celmar Costa França*, Leonardo da Costa Bastos, Teobaldo Cuya, Mehdi Sirouspour, Franklin Chacón-Huete, David Bendahan and Pat Forgione*





Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone

, 2020; 17(4): 512 - 517

Ognyan Ivanov Petrov, Yordanka Borisova Ivanova*, Mariana Stefanova Gerova and Georgi Tsvetanov Momekov




New Hydrazone Derivatives of Pyrazole-4-carboxaldehydes Exhibited Anti-inflammatory Properties

, 2020; 17(4): 502 - 511

Mingxia Song, Bing Liu, Shengwang Yu, Shihui He, Yuqiu Liang, Sifan Li, Qiuyan Chen and Xianqing Deng*




In Silico Elucidation of the Molecular Recognition of Phenol Derivative Compounds and Hippuryl-histidyl-leucine as an Artificial Substrate with the Experimental Target: Angiotensin-converting Enzyme

, 2020; 17(4): 445 - 466

Víctor Hugo Vázquez-Valaldez*, Manuel Alejandro Hernández S, Ivonne Carrillo Cedillo, Ana María Velázquez Sanchez, Mildred Sauce Guevara, Rafael López Castañares and Enrique Ángeles




In vitro and In Vivo Evaluation of Quinoxaline 1,4-di-N-oxide Against Giardia lamblia

, 2020; 17(4): 428 - 433

Elizabeth Barbosa-Cabrera, Rosa Moo-Puc, Antonio Monge, Alma Delia Paz-González, Virgilio Bocanegra-García and Gildardo Rivera*





Most Cited Articles


Research Article

(Substituted)-benzo[b]thiophene-4-carboxamide synthesis and antiproliferative activity study

, 2020; 17(5): 563-573.

Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*


DOI: 10.2174/1570180815666181004114125


Research Article

Lead molecules as novel aromatase inhibitors: In silico de novo designing and binding affinity studies

, 2020; 17(5): 655-665.

Laxmi Banjare, Sant Kumar Verma, Akhlesh Kumar Jain and Suresh Thareja*


DOI: 10.2174/1570180816666190703152659


Research Article

New 2-oxopyridine/2-thiopyridine derivatives tethered to a benzotriazole with cytotoxicity on MCF7 cell lines and with antiviral activities

, 2020; 17(2): 124-137.

Adel Mahmoud Attia, Ahmed Ibrahin Khodair*, Eman Abdelnasser Gendy, Mohammed Abu El-Magd and Yaseen Ali Mosa Mohamed Elshaier*


DOI: 10.2174/1570180816666190220123547


Letter

Synthesis and antimicrobial activity of thiohydantoins obtained from L-amino acids

, 2020; 17(1): 94-102.

Priscila Goes Camargo de Carvalho, Jhonatan Macedo Ribeiro, Renata Perugini Biasi Garbin, Gerson Nakazato, Sueli Fumie Yamada Ogatta, Ângelo de Fátima, Marcelle de Lima Ferreira Bispo and Fernando Macedo*


DOI: 10.2174/1570180816666181212153011





Research Article

An environment-friendly synthesis of piperonal chalcones and their cytotoxic and antioxidant evaluation

, 2020; 17(2): 138-144.

Sanal Dev, Della Grace Thomas Parambi, Bency Baby, Githa Elizabeth Mathew, Hendawy Omnia Magdy, Monu Joy, Shine Sudev and Bijo Mathew*


DOI: 10.2174/1570180815666181016155934


Letter

Synthesis of piperidine conjugated dihydroquinazolin-4(1h)-ones and their antiproliferative activity, molecular docking studies and DFT calculations

, 2020; 17(1): 85-93.

Kereyagalahally Honneshappa Narasimhamurthy, Chandra, Toreshettahally Ramesh Swaroop, Swamy Jagadish and Kanchugarakoppal Subbegowda Rangappa*


DOI: 10.2174/1570180816666190613120349


Research Article

Antimicrobial activity, antioxidant properties and phytochemical screening of aesculus hippocastanum mother tincture against food-borne bacteria

, 2020; 17(1): 48-56.

Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso and Giovanni Salzano


DOI: 10.2174/1570180816666181108114115


Letter

One-pot synthesis of betulin triterpenoid quaternized pyridine derivatives and their antimicrobial activity

, 2020; 17(1): 79-84.

Elvira Rifovna Shakurova, Darina Alexandrovna Pozdnyakova, Elena Valeryevna Tretyakova and Lyudmila Vyacheslavovna Parfenova*


DOI: 10.2174/1570180816666181217123629



Research Article

Synthesis of limonin derivatives with improved anti-inflammatory and analgesic properties

, 2020; 17(3): 285-299.

Chengshu Jia, Bin Hu, Yingying Ji, Yourui Su, Guoqing Gong, Qihua Zhu and Yungen Xu*


DOI: 10.2174/1570180816666181113102359


Research Article

Cephalosporin conjugated sulfonamides: Synthesis, characterization and anticancer activities

, 2020; 17(3): 264-270.

Rana Asif Nadeem, Muhammad Abdul Qadir, Mahmood Ahmed* and Imran Sajid


DOI: 10.2174/1570180815666180820144621



Most Accessed Articles



Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787-798.

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *


DOI: 10.2174/1570180816666191024102231






Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

, 2020; 17(6): 725-730.

Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*


DOI: 10.2174/1570180816666190716141524











Editor-in-Chief

graphic
K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)
Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.

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