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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access
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In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of the latest Internet technology for both the submission and review of manuscripts. The journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery


Volume 17


Number 9

Biography   Open Access

Review Article

Review Article

Review Article

Research Article

Research Article

Research Article

Research Article

Indole Curcumin Reverses Multidrug Resistance by Reducing the Expression of ABCB1 and COX2 in Induced Multidrug Resistant Human Lung Cancer Cells

, 17(9): 1146 - 1154

Sankar Pajaniradje , Kumaravel Mohankumar, Rakesh Radhakrishnan , Shamim Akhtar Sufi, Srividya Subramanian , Parthiban Anaikutti, Surya Prakash Rao Hulluru and Rukkumani Rajagopalan *

DOI: 10.2174/1570180817666200402124503

Articles Ahead of Print

Identification of Putative "Multifunctional Drug" Against Anthrax Toxins via Integrative Computational Approach

Nousheen Bibi*, Sehraiz Razzaq, Faisal Nouroz, Farhat Amin, Ambreen Shahnaz and Mohammad Amjad Kamal

DOI: 10.2174/1570180817999200818175544
View Abstract

Novel Coronavirus 2019 Outbreak: A Global Epidemic

Sweta Kamboj*, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Rohit Dutt

DOI: 10.2174/1570180817999200802033916
View Abstract

Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice

Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines

, 2020; 17(2): 104 - 113

Hui Zhao, Xiaoxia Hu, Yue Zhang, Chunlei Tang* and Bainian Feng*

DOI: 10.2174/1570180815666181017120100

Targeting Inflammation with Conjugated Cinnamic Amides, Ethers and Esters

, 2020; 17(1): 3 - 11

Ioannis Fotopoulos, Eleni Pontiki and Dimitra Hadjipavlou Litina*

DOI: 10.2174/1570180816666181129125511

Molecular Modeling of an Orphan GPR18 Receptor

, 2019; 16(10): 1167 - 1174

Kamil J. Kuder, Tadeusz Karcz, Maria Kaleta and Katarzyna Kiec-Kononowicz*

DOI: 10.2174/1570180815666180810114847

Open Access Articles

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *

Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure

, 2020; 17(6): 772 - 786

Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*

A Series of Furan-based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity

, 2020; 17(3): 312 - 322

Mehlika Dilek Altintop*, Belgin Sever, Özlem Atli Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir

Synthesis of Piperidine Conjugated Dihydroquinazolin-4(1H)-ones and their Antiproliferative Activity, Molecular Docking Studies and DFT Calculations

, 2020; 17(1): 85 - 93

Kereyagalahally Honneshappa Narasimhamurthy, Chandra, Toreshettahally Ramesh Swaroop, Swamy Jagadish and Kanchugarakoppal Subbegowda Rangappa*

Synthesis and Analgesic Activity of Monoterpenoid Aldehyde-derived Hydro-2H-chromeneols

, 2020; 17(1): 68 - 78

Irina Il'ina*, Ekaterina Morozova, Dina Korсhagina, Konstantin Volсho, Tat'yana Tolstikova and Nariman Salakhutdinov

Identifying the Structural Features of Diphenyl Ether Analogues for InhA Inhibition: A 2D and 3D QSAR Based Study

, 2020; 17(1): 31 - 47

Ashutosh Prasad Tiwari, Varadaraj Bhat Giliyar*, Gurypur Gautham Shenoy and Vandana Kalwaja Eshwara

Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

, 2019; 16(12): 1387 - 1394

Mark Gallant Fulton, Matthew Thomas Loch, Caroline Anne Cuoco, Alice Lambert Rodriguez, Emily Days, Paige Newton Vinson, Krystian Andrezej Kozek, Charles David Weaver, Anna Louise Blobaum, Peter Jeffrey Conn, Colleen Marie Niswender* and Craig William Lindsley*

Antitumor Activity of Cyclodextrin-based Supramolecular Platinum Prodrug In vitro and In vivo

, 2019; 16(11): 1296 - 1301

Yu-Hui Zhang, Jie Wang, Siqintana Xin, Li-Juan Wang and Xianliang Sheng*

Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions

, 2019; 16(11): 1248 - 1257

Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich

Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies

, 2019; 16(9): 994 - 1005

Naveen Kumar, Swamy Sreenivasa*, Bhuvanesh Sukhlal Kalal, Vasantha Kumar, Bantwal Shivarama Holla, Vinitha Ramanath Pai, Nadigar Revansiddappa Mohan and Shivaraj Govindaiah

The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen

Most Cited Articles

Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*

DOI: 10.2174/1570180815666180704103047

Research Article

Novel 1,3,4-oxadiazole fused thiadiazole derivatives: Synthesis and study of anticancer activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*

DOI: 10.2174/1570180816666181031125946

Research Article

(Substituted)-benzo[b]thiophene-4-carboxamide synthesis and antiproliferative activity study

, 2020; 17(5): 563-573.

Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*

DOI: 10.2174/1570180815666181004114125

Research Article

Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin B<inf>6</inf> and different heteroaromatic nucleus

, 2019; 16(7): 792-798.

Thais Cristina Mendonça Nogueira, Lucas dos Santos Cruz, Maria Cristina Lourenço and Marcus Vinicius Nora de Souza*

DOI: 10.2174/1570180815666180627122055

Research Article

Design, synthesis and cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids as potent anti-breast cancer agents

, 2019; 16(7): 818-824.

Maryam Mohammadi-Khanaposhtani, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi and Tahmineh Akbarzadeh*

DOI: 10.2174/1570180815666180627121006

Research Article

Synthesis, characterization, free-radical scavenging capacity and antioxidant activity of novel series of hydrazone, 1,3,4-oxadiazole and 1,2,4-triazole derived from 3,5-dimethyl-1H-pyrazole

, 2019; 16(7): 712-720.

Khalid Karrouchi*, Saad Fettach, Smaail Radi*, El bekkaye Yousfi, Jamal Taoufik, Yahia Nasser Mabkhot, Seham Alterary, My El Abbes Faouzi and Muhammed Ansar

DOI: 10.2174/1570180815666180516103050

Research Article

Antimicrobial activity, antioxidant properties and phytochemical screening of aesculus hippocastanum mother tincture against food-borne bacteria

, 2020; 17(1): 48-56.

Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso and Giovanni Salzano

DOI: 10.2174/1570180816666181108114115


One-pot synthesis of betulin triterpenoid quaternized pyridine derivatives and their antimicrobial activity

, 2020; 17(1): 79-84.

Elvira Rifovna Shakurova, Darina Alexandrovna Pozdnyakova, Elena Valeryevna Tretyakova and Lyudmila Vyacheslavovna Parfenova*

DOI: 10.2174/1570180816666181217123629

Review Article

Potential of nanoparticles in combating Candida infections

, 2019; 16(5): 478-491.

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani

DOI: 10.2174/1570180815666181015145224

General Research Article

Novel tri-substituted thiazoles bearing piperazine ring: Synthesis and evaluation of their anticancer activity

, 2019; 16(5): 547-555.

Asaf Evrim Evren*, Leyla Yurttaş , Busra Eksellı and Gulsen Akalın-Cıftcı

DOI: 10.2174/1570180815666180731122118

Research Article

N-acetylserotonin vs melatonin: In-vitro controlled release from hydrophilic matrix tablets

, 2019; 16(3): 347-352.

M. Vlachou*, G. Stavrou, A. Siamidi, S. Flitouri, V. Ioannidou and S. Mavrokordopoulos

DOI: 10.2174/1570180815666180404125519

Most Accessed Articles

Current Strategies and Approaches in Combating SARS-CoV-2 Virus that Causes COVID-19

, 2020; 17(5): 672-674.

D. Sivaraman*, P. S. Pradeep, S. Sundar Manoharan, C. Ramachandra Bhat, K. V. Leela and V. Venugopal

DOI: 10.2174/157018081705200403092546

A Series of Furan-based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity

, 2020; 17(3): 312-322.

Mehlika Dilek Altintop*, Belgin Sever, Özlem Atli Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir

DOI: 10.2174/1570180816666190325163948

New Hybrids Derived from the Natural Compound (-)-β-Pinene and Amides or Acylthioureas as Antitumor Agents

, 2020; 17(3): 271-284.

Shengliang Liao, Xiaoping Rao, Minggui Shen, Hongyan Si, Jie Song, Shibin Shang* and Zhanqian Song*

DOI: 10.2174/1570180816666181107094427

Novel Strobilurin Derivatives Containing Carboxylate Unit as Potential Antifungal Agents

, 2020; 17(3): 300-311.

Longzhu Bao, Shuangshuang Wang, Di Song, Jingjing Wang, Xiali Yue and Xiufang Cao*

DOI: 10.2174/1570180816666190325164452

Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties

, 2020; 17(3): 285-299.

Chengshu Jia, Bin Hu, Yingying Ji, Yourui Su, Guoqing Gong, Qihua Zhu and Yungen Xu*

DOI: 10.2174/1570180816666181113102359


K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.05


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