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Letters in Drug Design & Discovery

Volume 16, 12 Issues, 2019
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

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  • 57th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

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Volume 16

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Number 11



Biography   Open Access



Review Article



Research Article

Synthesis, Anti-proliferative Evaluation, and Molecular Docking Studies of 3-(alkylthio)-5,6-diaryl-1,2,4-triazines as Tubulin Polymerization Inhibitors

, 16(11): 1194 - 1201

Farhad Saravani, Ebrahim Saeedian Moghadam, Hafezeh Salehabadi, Seyednasser Ostad, Morteza Pirali Hamedani, Massoud Amanlou, Mohammad Ali Faramarzi and Mohsen Amini*


DOI: 10.2174/1570180815666180727114216


Research Article



Research Article



Research Article



Research Article   Open Access



Research Article



Articles Ahead of Print





Synthesis and Antimicrobial Activity of Adamantyl Substituted Pyridoxine Derivatives


Rail Khaziev, Nikita Shtyrlin, Roman Pavelyev, Raushan Nigmatullin, Raylya Gabbasova, Denis Grishaev, Anna Shtro, Anastasia Galochkina , Yulia Nikolaeva , Tatiana Vinogradova , Olga Manicheva, Marine Dogonadze, Oleg Gnezdilov , Evgeny Sokolovich, Peter Yablonskiy, Konstantin Balakin and Yurii Shtyrlin*


DOI: 10.2174/1570180816666190911150705
View Abstract




New Hydrazone Derivatives of Pyrazole-4-carboxaldehydes Exhibited Anti-inflammatory Properties


Mingxia Song, Xianqing Deng*, Bing Liu, Shengwang Yu, Shihui He, Yuqiu Liang, Sifan Li and Qiuyan Chen


DOI: 10.2174/1570180816666190731113441
View Abstract



Synthesis, In Silico and In Vivo Evaluation of Novel 1, 3, 4-Thiadiazole Analogues as Novel Anticancer Agents


Byran Gowramma*, Swathi Krishna, Manal Mohammed, Thaggikuppe K Praveen, Rajagopal Kalirajan and L Kaviarasan


DOI: 10.2174/1570180816666190710145939
View Abstract


Abstracts Ahead of Print


In silico elucidation of the molecular recognition of phenol derivative compounds and Hippuryl-histidyl-leucine as an artificial substrate with the experimental target: angiotensin-converting enzyme.


Víctor H. Vázquez-Valaldez*, Manuel Alejandro HernándezS, Ivonne Carrillo C, Ana María VelázquezS, Mildred SauceG, Rafael López Castañares and E. Ángeles


DOI: 10.2174/1570180816666190906155034
View Abstract



Published Contents

Editor's Choice


Molecular Modeling of an Orphan GPR18 Receptor

, 2019; 16(10): 1167 - 1174

Kamil J. Kuder, Tadeusz Karcz, Maria Kaleta and Katarzyna Kiec-Kononowicz*


DOI: 10.2174/1570180815666180810114847



The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen


DOI: 10.2174/1570180816666181122122655



Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

, 2019; 16(8): 882 - 891

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu


DOI: 10.2174/1570180815666180803124625





Potential of Nanoparticles in Combating Candida Infections

, 2019; 16(5): 478 - 491

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224





Synthesis and Antichlamydial Activity of Novel Phenazines

, 2019; 16(2): 174 - 181

Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang* and Yu Zhao*


DOI: 10.2174/1570180815666180518112952



Open Access Articles

Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions

, 2019; 16(11): 1248 - 1257

Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich




In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration

, 2019; 16(8): 948 - 960

Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*




A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive

, 2019; 16(3): 238 - 244

Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*




Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2019; 16(2): 102 - 110

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid

, 2018; 15(7): 713 - 720

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

, 2018; 15: 1 - 7 (E-Pub Ahead of Print)

Mark G. Fulton, Matthew T. Loch, Caroline A. Cuoco, Alice L. Rodriguez, Emily Days, Paige N. Vinson, Krystian A. Kozek, C David Weaver, Anna L. Blobaum, Jeff Conn, Colleen M. Niswender and Craig W. Lindsley*




L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737 - 742

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*




The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets

, 2017; 14(2): 233 - 239

Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich




In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

, 2017; 14(2): 125 - 134

Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke




Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475 - 478

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich






4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

, 2015; 12(2): 131 - 139

Maria Antonietta Dettori, Davide Fabbri, Marina Pisano, Carla Rozzo, Giuseppe Palmieri, Alessandro Dessi, Roberto Dallocchio and Giovanna Delogu




Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

, 2014; 11(3): 331 - 338

Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood




Optimized Synthesis of Etidronate

, 2013; 10(8): 733 - 737

Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich





Most Cited Articles

Research Article

Synthesis and mosquiticidal activity of novel hydrazone containing pyrimidine derivatives against aedes aegypti

, 2018; 15(9): 951-956.

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep , David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640


Research Article

Synthesis, nematicidal activity and docking study of novel pyrazole-4-carboxamide derivatives against meloidogyne incognita

, 2018; 16(1): 29-35.

Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng* and Xing-Hai Liu*


DOI: 10.2174/1570180815666180326150827


Research Article

Computational approach to the discovery of phytochemical molecules with therapeutic potential targets to the PKCZ protein

, 1 May 2018; 15(5): 488-499.

Poliany G. Freitas*, Thiago C. Elias, Icaro A. Pinto, Luciano T. Costa, Paulo V.S.D. de Carvalho, Daniel de Q. Omote, Ihosvany Camps, Tati Ishikawa, Helen A. Arcuri, Susana Vinga, Arlindo L. Oliveira, Walter F.A. Junior and Nelson J.F. da Silveira


DOI: 10.2174/1570180814666170810120150


Research Article

Synthesis and antifungal activity of some 6-tert-butyl-8-chloro-2, 3-dimethylquinolin-4-ol derivatives against Pyricularia oryae

, 2018; 15(12): 1314-1318.

Yue-Ming Fang, Rui-Rui Zhang, Zhong-Hua Shen, Cheng-Xia Tan, Jian-Quan Weng, Tian-Ming Xu*, Xing-Hai Liu*, Hong-Ying Huang and Hong-Ke Wu


DOI: 10.2174/1570180815666180313121735


Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*


DOI: 10.2174/1570180815666180704103047


Research Article

Synthesis, biological evaluation and docking studies of 1,3,4-oxadiazole fused benzothiazole derivatives for anticancer drugs

, 2018; 15(12): 1299-1307.

Madala Subramanyam, Reddymasu Sreenivasulu, Rambabu Gundla, Mandava V.B. Rao and Koya Prabhakara Rao *


DOI: 10.2174/1570180815666180219165119


Research Article

Synthesis and biological evaluation of new quinoline-based thiazolyl hydrazone derivatives as potent antifungal and anticancer agents

, 1 February 2018; 15(2): 193-202.

Ali Erguc, Mehlika Dilek Altintop*, Ozlem Atli, Belgin Sever, Gokalp Iscan, Gozde Gormus and Ahmet Ozdemir


DOI: 10.2174/1570180814666171003145227


Research Article

Novel azole-functionalited flouroquinolone hybrids: Design, conventional and microwave irradiated synthesis, evaluation as antibacterial and antioxidant agents

, 2018; 15(1): 46-64.

Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz


DOI: 10.2174/1570180814666170823163540


Research Article

Biological activities and docking studies on novel bis 1,4-DHPS linked to arene core via ether or ester linkage

, 2018; 15(10): 1036-1045.

Nada S. Ibrahim, Magda F. Mohamed, Ahmed H. M. Elwahy* and Ismail A. Abdelhamid*


DOI: 10.2174/1570180815666180105162323


Research Article

Design, synthesis, and screening of hybrid benzothiazolyl-oxadiazoles as anticonvulsant agents

, 1 April 2018; 15(4): 398-405.

Sheikh Murtuja, Mohammad Shaquiquzzaman and Mohammad Amir*


DOI: 10.2174/1570180814666170526154914


Research Article

Arginine- and lysine-rich peptides: Synthesis, characterization and antimicrobial activity

, 2018; 15(3): 220-226.

Adriano Mollica*, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Stefano Morosetti, Pasqualina Punzi and Sako Mirzaie


DOI: 10.2174/1570180814666170213161341



Research Article

Efficient synthesis of ibandronate in the presence of an ionic liquid

, 1 January 2018; 15(7): 713-720.

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*


DOI: 10.2174/1570180814666171027160324


Research Article

Synthesis and antioxidant evaluation of a new class of thienopyrimidinerhodanine hybrids

, 1 February 2018; 15(2): 118-126.

Kerru Nagaraju , Venkata H.S.S. Bhaskaruni, Ravada Kishore , Suresh Maddila*, Parvesh Singh and Sreekantha B. Jonnalagadda


DOI: 10.2174/1570180814666170710161844


Research Article

Synthesis and assessment of novel anti-chlamydial benzylidene acylhydrazides derivatives

, 2018; 15(1): 31-36.

Xiaofeng Bao, Ying Xue, Chao Xia, Yin Lu, Ningjing Yang and Yu Zhao*


DOI: 10.2174/1570180814666170526170227



Most Accessed Articles

Design, Synthesis and Anti Colon Cancer Activity Evaluation of Phosphorylated Derivatives of Lamivudine (3TC)

, 2011; 8(1): 59-64.

Valasani Koteswara Rao, Sanapalli S. Reddy, Balam S. Krishna, Cirandur S. Reddy, Nimmanapalli P. Reddy, Tamatam C.M. Reddy, Chamarthi N. Raju and S. K. Ghosh


DOI: 10.2174/157018011793663921







Design, Synthesis and Evaluation of Thiourea Derivatives as Antimicrobial and Antiviral Agents

, 2019; 16(6): 618-624.

Veerasamy Ravichandran*, Sivadasan Shalini, Krishnan Suresh Kumar, Harish Rajak and Ram Kishore Agrawal


DOI: 10.2174/1570180815666180801120440


Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*


DOI: 10.2174/1570180816666181031125946






Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

Biography View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
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