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"Letters in Drug Design & Discovery should be available in every library in the pharmaceutical industry and in universities."

R. F. Borne, Associate Director
Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, USA

Forthcoming Special Issues

Opportunities and challenges in anticandidal drug discovery and development


Guest Editor(s): Mohammad Abid
Tentative Publication Date: September, 2018
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Published Special Issues

NEW INSIGHTS ON CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF NATURAL PRODUCTS


Letters in Drug Design & Discovery, Volume 15, Number 03
Guest Editor(s): Gokhan Zengin, Marcello Locatelli

Authors' Comments
I would like to thank Bentham Science Publishers for their peerless effort to keep up scientists and students updated with the latest science and research work. Actually, Bentham assists researchers to achieve their goals to spread their reputation worldwide. I have experienced sincere, efficient and effective communication while dealing with Bentham team members. I intend to submit my work to Bentham and try to pick up journals that match my research profile. I have submitted a recent work to Medicinal Chemistry and nowadays I am drafting a manuscript targeting Current Pharmaceutical Design. Honestly, no words neither sentences would express my gratefulness and admiration. Bentham has offered my institution three months trial to access their journal lists and surf on its Board. This free access trial fulfills my literature review and broadens my horizon to absorb the recent research in pharmaceutical sciences and medicinal chemistry. Finally, I wish Bentham more success and achievement!

Dima Sabbah
(Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan)


Letters in Drug Design & Discovery

,

Volume 15

-

Number 11



Biography   Open Access



Research Article

Oxime K033-Reactivation Activity of Cholinesterases Inhibited by Various Nerve Agents and Organophosphorus Pesticides

, 15(11): 1124 - 1130

Kamil Kuca*, Kamil Musilek, Daniel Jun, Jaroslav Pejchal, Ondrej Krejcar, Marek Penhaker, Qinghua Wu, Raquel O. Lopes, Teodorico C. Ramalho, Tanos C.C. Franca, Eugenie Nepovimova and Ondrej Soukup


DOI: 10.2174/1570164615666180713112238




Research Article

Design, Synthesis and Characterization of Novel Urolithin Derivatives as Cholinesterase Inhibitor Agents

, 15(11): 1131 - 1140

Maryam Norouzbahari, Emine V. Burgaz, Tugba Ercetin, Amirhossein Fallah, Alireza Foroumadi, Loghman Firoozpour, Mustafa F. Sahin, Mustafa Gazi and Hayrettin O. Gulcan*


DOI: 10.2174/1570180815666180115144608




Research Article



Research Article

Radioprotective Effect of Sinapic Acid Against Genotoxicity and Apoptosis Induced by Ionizing Radiation on Human Lymphocytes

, 15(11): 1147 - 1154

Fatemeh Alizadeh, Mohammad Asghari, Seyedeh Atekeh Torabizadeh, Najmeh Rahmanian, Arash Ghasemi and Seyed Jalal Hosseinimehr*


DOI: 10.2174/1570180815666180219163626




Research Article

Inhibition of DNA Topoisomerases by a Series of Benzoxazoles and their Possible Metabolites

, 15(11): 1155 - 1162

Fatma Zilifdar*, Egemen Foto, Tugba Ertan-Bolelli, Ilkay Yildiz , Esin Aki-Yalcin and Nuran Diril


DOI: 10.2174/1570180815666180124143246




Research Article

Averrhoa bilimbi L. leaf Aqueous Extract Modulates both Cardiac Contractility and Frequency in the Guinea-pig Atrium by the Activation of Muscarinic Receptors

, 15(11): 1163 - 1169

Anne Caroline Oliveira dos Santos, Diego Santos Souza, Thassio Ricardo Ribeiro Mesquita, Jose Evaldo Rodrigues de Menezes-Filho, Ana Paula Duarte Caldas, Americo Azevedo de Souza , Gilmara Beatriz Andrade da Silva , Evaleide Diniz de Oliveira, Leonardo Rodrigues dos Santos and Carla Maria Lins de Vasconcelos*


DOI: 10.2174/1570180815666180125150457




Research Article

6-Methoxy-3,4-dihydronaphthalenone Chalcone-like Derivatives as Potent Tyrosinase Inhibitors and Radical Scavengers

, 15(11): 1170 - 1179

Sara Ranjbar, Abdolhossein Akbari, Najmeh Edraki, Mahsima Khoshneviszadeh, Hajar Hemmatian, Omidreza Firuzi and Mehdi Khoshneviszadeh*


DOI: 10.2174/1570180815666180219155027




Articles Ahead of Print

3D-QSAR Studies of S-DABO Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors


Yueping Wang, Jie Chang, Jiangyuan Wang, Peng Zhong, Yufang Zhang, Christopher Cong Lai and Yanping He*


View Abstract



Evaluation of the in vitro Antitumor Activity of Nanostructured Cyclotides in Polymers of Eudragit® L 100-55 and RS 30 D


Osmar N. Silva*, Michelle F. S. Pinto, Juliane F. C. Viana, Camila G. Freitas, Isabel C.M. Fensterseifer, David J. Craik and Octavio L. Franco


View Abstract


Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an in vivo and in vitro Study


Nima Naderi, Seyed Mostafa Ghasemi Najarkolaee, Mona Modanlookordi, Mohammad Shokrzadeh and Hamid Irannejad*


View Abstract


Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents


Sarva Santhisudha, Tenkayala Sobha Rani, Peddaiahgari Vasu Govardhana Reddy and Cirandur Suresh Reddy


View Abstract


Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study


Xing-Hai Liu*, Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Bao-Ju Li


View Abstract


Molecular Modeling of an Orphan GPR18 Receptor


Kamil J. Kuder , Tadeusz Karcz, Maria Kaleta and Katarzyna Kiec-Kononowicz*


View Abstract


Synthesis, Characterization, Free-radical Scavenging Capacity and Antioxidant Activity of Novel Series of Hydrazone, 1,3,4-oxadiazole and 1,2,4- triazole Derived from 3,5-dimethyl-1H-pyrazole


Khalid Karrouchi*, Saad Fettach, Smaail Radi, El bekkaye Yousfi, Jamal Taoufik, Yahia N. Mabkhout, Seham Alterary, My El Abbes Faouzi and M`hammed Ansar


View Abstract


Identification of New Inhibitors of Mutant Isocitrate Dehydrogenase 2 through Molecular Similarity-based Virtual Screening


Lijun Yang, Stefan Pusch, Victoria Jennings, Tianfang Ma, Qihua Zhu, Yungen Xu, Andreas von Deimling and Xiaoming Zha*


View Abstract


Design, Synthesis and Pharmacological Evaluation of Novel Antiinflammatory and Analgesic O-Benzyloxime Compounds Derived From Natural Eugenol


Rodrigo César da Silva, Fabiano Veiga, Fabiana Cardoso Vilela, André Victor Pereira, Thayssa Tavares da Silva Cunha, Roberta Tesch, Claudio Viegas Jr., Danielle Ferreira Dias, Alexandre Giusti-Paiva, Marcia Paranho Veloso and Carlos Alberto Manssour Fraga*


View Abstract


Abstracts Ahead of Print

An Environment-Friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation


Sanal Dev, Della Grace Thomas Parambi, Benncy Baby, Githa Elizabeth Mathew, Hendawy OM, Monu Joy, Shine Sudev and Bijo Mathew*


View Abstract


Potential of nanoparticles in combating Candida infections


Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


View Abstract





Synthesis of Pyridinyl-benzo[d]imidazole/Pyridinyl-benzo[d]thiazole Derivatives and their Yeast Glucose uptake Activity In Vitro


Momin Khan*, Riaz Ahmad, Gauhar Rehman, Naeem Gul, Uzma Salar, Khalid M. Khan, Shahnaz Perveen and Sana Shah


View Abstract


Design and synthesis of novel thiosemicarbazones as potent anti-breast cancer agents


Mashooq Ahmad Bhat, M. Al-Tahhan, Mohamed Al-Omar and Ahmed M. Naglah


View Abstract





Editor's Choice

Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

, 2018; 15(9): 951 - 956

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640



Inhibitory Effects of 1,4-disubstituted Thiosemicarbazide Derivatives on Streptococcus mutans and Streptococcus sanguinis Mono-species Biofilms

, 2018; 15(8): 843 - 850

Malgorzata Miazga-Karska, Maciej Wos, Agnieszka A. Kaczor, Anna Pachuta-Stec, Grazyna Ginalska and Monika Pitucha*


DOI: 10.2174/1570180814666171012164241



Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

, 2018; 15(7): 787 - 795

Pegah Khosravian, Mehdi Khoobi, Mehdi Shafiee Ardestani, Mohammad Porgham Daryasari, Malihe Hassanzadeh, Payam Ghasemi-Dehkordi, Massoud Amanlou and Hamid Akbari Javar*


DOI: 10.2174/1570180815666180117155818



Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti

, 2018; 15(6): 671 - 677

Mehlika Dilek Altintop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asim Kaplancikli and Ahmet Ozdemir


DOI: 10.2174/1570180814666171002155548





Antimicrobial, Gastroprotective and Healing Effect of the Hydroalcoholic Extract of Astronium fraxinifolium

, 2018; 15(3): 325 - 334

Anita Oliveira Brito Pereira Bezerra Martins, Ana Luiza Albuquerque Siebra, Cicera Datiane de Morais Oliveira, Gerlania Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Bolignon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesario, Thales Silva Coutinho, Lucindo Jose Quintans-Junior and Irwin Rose Alencar de Menezes*


DOI: 10.2174/1570180814666170213160114





Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

, 2017; 14(11): 1316 - 1323

Bakr F. Abdel-Wahab*, Abdelbasset A. Farahat, Ghada E. A. Awad and Gamal A. El-Hiti*


DOI: 10.2174/1570180814666170327162447



Open Access Articles

A Study on the Synthesis of Risedronic Acid; The Role of an Ionic Liquid Additive

, 2018; 15: 1 - 7 (E-Pub Ahead of Print)

David Illes Nagy, Alajos Grun, Julia Sinkovicz, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




Synthesis and Biological Evaluation of some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2018; 15: 1 - 9 (E-Pub Ahead of Print)

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




Synthesis and Anti-Oxidant Evaluation of Some Novel Sulfa Drugs

, 2017; 14(12): 1425 - 1432

Moustafa A. Gouda* and Belal H.M. Hussein




L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737 - 742

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*




Synthesis of Novel 4-(Dimethylaminoalkyl)piperazine-1-carbodithioa t e Derivatives as Cholinesterase Inhibitors

, 2017; 14(5): 528 - 539

Ulviye Acar Cevik, Serkan Levent, Begum Nurpelin Saglık, Yusuf Ozkay* and Zafer Asım Kaplancıklı




In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

, 2017; 14(2): 125 - 134

Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke




Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475 - 478

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich






4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

, 2015; 12(2): 131 - 139

Maria Antonietta Dettori, Davide Fabbri, Marina Pisano, Carla Rozzo, Giuseppe Palmieri, Alessandro Dessi, Roberto Dallocchio and Giovanna Delogu




Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

, 2014; 11(3): 331 - 338

Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood




Optimized Synthesis of Etidronate

, 2013; 10(8): 733 - 737

Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich






Selective Androgen Receptor Modulators Antagonize Apolipoprotein E4-Induced Cognitive Impairments

, 2008; 5(4): 271 - 276

Summer Acevedo, Luis Gardell, Stefania Risso Bradley, Fabrice Piu and Jacob Raber





Most Cited Articles

Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

, 2016; 13(6): 521-525.

Zhi-Wen Zhai, Yan-Xia Shi, Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li and Yong-Gang Zhang


DOI: 10.2174/157018081306160618181757








Synthesis of Novel C3-Linked β-Carboline-Pyridine Derivatives Employing Khronke Reaction: DNA-binding Ability and Molecular Modeling Studies

, 2016; 13(4): 335-342.

Nagula Shankaraiah, Pankaj Sharma, Srinivas Pedapati, Shalini Nekkanti, Vunnam Srinivasulu, Niggula Praveen Kumar and Ahmed Kamal


DOI: 10.2174/157018081304160303180050



Prediction of Caco-2 Cell Permeability Using Bilinear Indices and Multiple Linear Regression

, 2016; 13(2): 161-169.

Huong Le-Thi-Thu, Yudith Canizares-Carmenate, Yovani Marrero-Ponce, Francisco Torrens and Juan A. Castillo-Garit


DOI: 10.2174/1570180812666150630183511


Synthesis and Antimicrobial Evaluation of Amphipathic Peptide Models

, 2016; 13(7): 715-724.

Marianna Sakka, Alexandra Balliou, Asimina Marianou, Dimitris Krikorian, Margarita Tsirogianni, Artemis Tsiligianni, Katerina Vartzeli, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou- Pomonis


DOI: 10.2174/1570180813666160616122410


Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475-478.

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich


DOI: 10.2174/1570180812666151022221805


Design, Synthesis and Mode of Action of Some New 2-(4'-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents

, 2016; 13(5): 429-437.

Meenakshi Singh, Sudhir Kumar Singh, Mayank Gangwar, Satheeshkumar Sellamuthu, Gopal Nath and Sushil K. Singh


DOI: 10.2174/1570180812666150821003220



Design and Synthesis of Novel Spiro-Piperidinyl Pyrazolone Derivatives and Their Potential Antiviral Activity

, 2016; 13(2): 149-160.

Rajagopalan Srinivasan, Badiadka Narayana, Balladka Kunhanna Sarojini, Veerakyathappa Bhanuprakash, Chenna Govindaraju Darshan Raj and Prakash S. Nayak


DOI: 10.2174/1570180812666150630182740



Most Accessed Articles

Synthesis and Cytotoxicity Evaluation of Novel Tricyclic Dihydropyrazolo [4,3-f][1,2,3]triazolo Diazepines

, 2018; 15(10): 1020-1025.

Chiranjeevi Bingi, Ashok Kale, Yedla Poornachandra, Chityal Ganesh Kumar and Krishnaiah Atmakur*


DOI: 10.2174/1570180815666180222143229


Synthesis of New Thiazolyl-Pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects

, 2018; 15(7): 744-756.

Belgin Sever, Mehlika Dilek Altıntop, Hulya Karaca Gencer, Handan Acelya Kapkac, Ozlem Atli, Merve Baysal and Ahmet Ozdemir*


DOI: 10.2174/1570180814666170925152902



2-Indolinone Derivatives as Potent Urease Inhibitors

, 2018; 15(8): 814-821.

Momin Khan*, Muhammad Yousaf, Abdul Wadood, Zahid Hussain, Muhammad Naeem, Khair Zaman, Sana Shah, Khalid Mohammed Khan and Shahnaz Perveen


DOI: 10.2174/1570180814666171116154110


Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475-478.

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich


DOI: 10.2174/1570180812666151022221805


Antimicrobial Activities of Synthetic Arylidine Nicotinic and Isonicotinic Hydrazones

, 2018; 15(10): 1057-1067.

Muhammad Hayat, Khalid Mohammed Khan*, Sumayya Saeed, Uzma Salar, Momin Khan, Taimoor Baig, Aqeel Ahmad, Shahnaz Parveen and Muhammad Taha


DOI: 10.2174/1570180814666170914120337


Synthesis and Antibacterial/Antitubercular/Antioxidant Activities of Compounds Containing Fluoroquinolone Ring Linked to a 4-thiazolidinone Moiety

, 2018; 15(10): 1087-1094.

Tejeswara Rao Allaka, Naresh Kumar Katari, Venkanna Banothu, Srinubabu Maddela, Manojit Pal* and Jaya Shree Anireddy*


DOI: 10.2174/1570180815666171229150032


L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737-742.

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*


DOI: 10.2174/1570180814666170216102632



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