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"Letters in Drug Design & Discovery should be available in every library in the pharmaceutical industry and in universities."

R. F. Borne, Associate Director
Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, USA

Forthcoming Special Issues

Antimalarial drug discovery - Exploration of novel structural scaffolds towards development of potent antimalarial agents


Guest Editor(s): Mithun Rudrapal, Dipak Chetia
Tentative Publication Date: July, 2019
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Special Issues - In-Press

Opportunities and challenges in anticandidal drug discovery and development


Guest Editor(s): Mohammad Abid
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Published Special Issues

NEW INSIGHTS ON CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF NATURAL PRODUCTS


Letters in Drug Design & Discovery, Volume 15, Number 03
Guest Editor(s): Gokhan Zengin, Marcello Locatelli

Authors' Comments
I would like to thank Bentham Science Publishers for their peerless effort to keep up scientists and students updated with the latest science and research work. Actually, Bentham assists researchers to achieve their goals to spread their reputation worldwide. I have experienced sincere, efficient and effective communication while dealing with Bentham team members. I intend to submit my work to Bentham and try to pick up journals that match my research profile. I have submitted a recent work to Medicinal Chemistry and nowadays I am drafting a manuscript targeting Current Pharmaceutical Design. Honestly, no words neither sentences would express my gratefulness and admiration. Bentham has offered my institution three months trial to access their journal lists and surf on its Board. This free access trial fulfills my literature review and broadens my horizon to absorb the recent research in pharmaceutical sciences and medicinal chemistry. Finally, I wish Bentham more success and achievement!

Dima Sabbah
(Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan)


Letters in Drug Design & Discovery

,

Volume 16

-

Number 2



Biography   Open Access



Research Article   Open Access

Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 16(2): 102 - 110

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*


DOI: 10.2174/1570180815666180803125935




Research Article

Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives

, 16(2): 111 - 118

Ahmet Cagri Karaburun, Nalan Gundogdu-Karaburun*, Leyla Yurttas, Ismail Kayagil and Seref Demirayak


DOI: 10.2174/1570180815666180606081042




Research Article



Research Article

The Impact of Antioxidants from the Diet on Breast Cancer Cells Monitored by Raman Microspectroscopy

, 16(2): 127 - 137

Paula Sofia Coutinho Medeiros, Ana Lúcia Marques Batista de Carvalho*, Cristina Ruano, Juan Carlos Otero and Maria Paula Matos Marques


DOI: 10.2174/1570180815666180502120804




Research Article

Indolin-2-one Derivatives: Theoretical Studies Aimed at Finding More Potent Aurora B Kinase Inhibitors

, 16(2): 138 - 152

Ítalo Antônio Fernandes, Tamiris Maria de Assis, Isael Aparecido Rosa and Elaine Fontes Ferreira da Cunha*


DOI: 10.2174/1570180815666180528090945




Research Article



Research Article

Synthesis, Antimicrobial Evaluation and In silico Studies of Novel 2,4- disubstituted-1,3-thiazole Derivatives

, 16(2): 160 - 173

Mir Mohammad Masood, Mohammad Irfan, Shadab Alam , Phool Hasan, Aarfa Queen, Shifa Shahid, Muhammad Zahid, Amir Azam and Mohammad Abid*


DOI: 10.2174/1570180815666180502120042




Articles Ahead of Print

Design, Synthesis and Antitumor Activity of Quinazoline Derivatives Bearing 2,3-Dihydro-indole or 1,2,3,4-Tetrahydroquinoline


Yiqiang Ou Yang, Bingbing Zhao, Xiuying Chen, Caolin Wang, Hong Zhang, Shuang Jia, Wufu Zhu* and Pengwu Zheng


View Abstract


Synthesis and Anticancer Activity of New Hydrazide-hydrazones and Their Pd(II) Complexes


Bedia Kocyigit-Kaymakcioglu*, Senem Sinem Yazici, Fatih Tok, Miris Dikmen, Selin Engur , Emine Elcin Oruc-Emre and Aysegul Iyidogan


View Abstract


Synthesis and Anti-Tumor Activity Evaluation of Novel 7-Fluoro-4-(1- Piperazinyl) Quinolines


Dan Liu*, Aiqi Xue, Zhixin Liu, Yi Zhang, Penghui Peng and Haifeng Wang


View Abstract



Paclitaxel-Tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery


Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li and Xinyuan Zhu


View Abstract


Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure


Sevil Senkardes, Esra Tatar, Ridvan Nepravishta, Dorisa Cela, Maurizio Paci, Ozlem Bingol Ozakpinar, Turgut Sekerler, Erik De Clercq, Christophe Pannecouque, S. Guniz Kucukguzel* and Ilkay Kucukguzel


View Abstract


Structure Based Identification of Potential Inhibitors of NS3 Protein of Zika virus


Md Imam Faizan, Abu Turab Naqvi , Md. Imtaiyaz Hassan, Mohd Abdullah, Ayesha Tazeen, Zoya Shafat, Malik Hisamuddin, Aftab Alam, Shahnawaz Ali, Sher Ali, Anam Farooqui, Abu Hamza, Nazish Parveen, Farah Deeba, Anwar Ahmed and Shama Parveen*


View Abstract



(Substituted)-benzo[b]thiophene-4-carboxamide Synthesis and Antiproliferative Activity Study


Chandrakant D. Pawar, Dattatraya N. Pansare and Devanand B. Shinde*


View Abstract


QSAR and Molecular Modeling Studies on a Series of Pyrrolidine Analogs Acting as BACE-1 Inhibitors


Richa Arya, Satya P. Gupta*, S. Paliwal, Seema Kesar, Achal Mishra and Y.S. Prabhakar


View Abstract


Abstracts Ahead of Print


Targeting inflammation with conjugate cinnamic amides, ethers and esters


Ioannis Fotopoulos, Eleni Pontiki and Dimitra Hadjipavlou-Litina*


View Abstract




The structure of MT189-tubulin complex provides insights into drug design


Zhongping Li, Yuxi Wang, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen


View Abstract



Synthesis and Analgesic Activity of Monoterpenoid Aldehyde-Derived Hydro-2H-chromeneols


Irina V. Il`ina*, Ekaterina A. Morozova*, Dina V. Korсhagina, Konstantin P. Volcho, Tat`yana G. Tolstikova and Nariman F. Salakhutdinov


View Abstract


Synthesis, antiproliferative, and antioxidant activities of substituted N-[(1,3,4-oxadiazol-2-yl)methyl]benzamines


Mohamed Jawed Ahsan, Lakshya Bhandari, Shally Makkar, Rajan Singh, Mohd. Zaheen Hassan, Mohammed H. Geesi, Mohammed Afroz Bakht, Surender Singh Jadav, Tuniki Balaraju, Yassine Riadi , Sandhya Rani, Habibullah Khalilullah, Vasubabu Gorantla and Afzal Hussain


View Abstract


Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties


Chengshu Jia, Bin Hub, Yingying Ji, Yourui Su, Guoqing Gong*, Qihua Zhu and Yungen Xu*


View Abstract


The natural products as hydroxymethylglutaryl-CoA reductase inhibitors


Hayrettin Ozan Gulcan*, Serkan Yigitkan and Ilkay Erdogan Orhan


View Abstract


Editor's Choice

Synthesis and Antichlamydial Activity of Novel Phenazines

, 2019; 16(2): 174 - 181

Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang* and Yu Zhao*


DOI: 10.2174/1570180815666180518112952



A New Class of Pure Estrogen Alpha Receptor Antagonists; Design, Synthesis and in-vitro Screening

, 2019; 16(1): 66 - 81

Akbar John Jameera Begam, Katike Ahamed Basheer, Selvaraj Jubie*, Srikanth Jupudi, Mohammed Afzal Azam and Palanisamy Dhanabal


DOI: 10.2174/1570180815666180327124634



Preparation and Characterization of GLUT1-mediated Novel Brain Targeting Magnetic Nanoparticles

, 2018; 15(12): 1308 - 1313

Li Zhang, Yi Zhao, Qiming Yue, Qiuyi Fu, Li Hai, Li Guo, Qiantao Wang* and Yong Wu*


DOI: 10.2174/1570180815666180322113934



Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

, 2018; 15(9): 951 - 956

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640



Inhibitory Effects of 1,4-disubstituted Thiosemicarbazide Derivatives on Streptococcus mutans and Streptococcus sanguinis Mono-species Biofilms

, 2018; 15(8): 843 - 850

Malgorzata Miazga-Karska, Maciej Wos, Agnieszka A. Kaczor, Anna Pachuta-Stec, Grazyna Ginalska and Monika Pitucha*


DOI: 10.2174/1570180814666171012164241



Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

, 2018; 15(7): 787 - 795

Pegah Khosravian, Mehdi Khoobi, Mehdi Shafiee Ardestani, Mohammad Porgham Daryasari, Malihe Hassanzadeh, Payam Ghasemi-Dehkordi, Massoud Amanlou and Hamid Akbari Javar*


DOI: 10.2174/1570180815666180117155818



Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti

, 2018; 15(6): 671 - 677

Mehlika Dilek Altintop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asim Kaplancikli and Ahmet Ozdemir


DOI: 10.2174/1570180814666171002155548





Antimicrobial, Gastroprotective and Healing Effect of the Hydroalcoholic Extract of Astronium fraxinifolium

, 2018; 15(3): 325 - 334

Anita Oliveira Brito Pereira Bezerra Martins, Ana Luiza Albuquerque Siebra, Cicera Datiane de Morais Oliveira, Gerlania Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Bolignon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesario, Thales Silva Coutinho, Lucindo Jose Quintans-Junior and Irwin Rose Alencar de Menezes*


DOI: 10.2174/1570180814666170213160114



Open Access Articles

Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2019; 16(2): 102 - 110

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid

, 2018; 15(7): 713 - 720

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




A Study on the Synthesis of Risedronic Acid; The Role of an Ionic Liquid Additive

, 2018; 15: 1 - 7 (E-Pub Ahead of Print)

David Illes Nagy, Alajos Grun, Julia Sinkovicz, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation

, 2017; 14(7): 752 - 762

Fathy M. Abdelrazek, Sobhi M. Gomha*, Aly H. Abdelrahman, Peter Metz and Mohsen A. Sayed




Alzheimer’s Disease Drugs- In Vitro Comparison of Cholinesterase Inhibition and beta-amyloid Modulation

, 2017; 14(6): 743 - 750

Ondrej Holas, Jan Korabecny, Zuzana Gazova, Katarina Siposova, Kamil Musilek, Veronika Opletalova, Lukas Gorecki, Eugenie Nepovimova, Katarina Spilovska, Eva Mezeiova and Kamil Kuca*




L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737 - 742

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*




The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets

, 2017; 14(2): 233 - 239

Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich




In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

, 2017; 14(2): 125 - 134

Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke




Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475 - 478

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich






4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

, 2015; 12(2): 131 - 139

Maria Antonietta Dettori, Davide Fabbri, Marina Pisano, Carla Rozzo, Giuseppe Palmieri, Alessandro Dessi, Roberto Dallocchio and Giovanna Delogu




Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

, 2014; 11(3): 331 - 338

Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood




Optimized Synthesis of Etidronate

, 2013; 10(8): 733 - 737

Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich






Most Cited Articles

Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

, 2016; 13(6): 521-525.

Zhi-Wen Zhai, Yan-Xia Shi, Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li and Yong-Gang Zhang


DOI: 10.2174/157018081306160618181757








Synthesis of Novel C3-Linked β-Carboline-Pyridine Derivatives Employing Khronke Reaction: DNA-binding Ability and Molecular Modeling Studies

, 2016; 13(4): 335-342.

Nagula Shankaraiah, Pankaj Sharma, Srinivas Pedapati, Shalini Nekkanti, Vunnam Srinivasulu, Niggula Praveen Kumar and Ahmed Kamal


DOI: 10.2174/157018081304160303180050



Prediction of Caco-2 Cell Permeability Using Bilinear Indices and Multiple Linear Regression

, 2016; 13(2): 161-169.

Huong Le-Thi-Thu, Yudith Canizares-Carmenate, Yovani Marrero-Ponce, Francisco Torrens and Juan A. Castillo-Garit


DOI: 10.2174/1570180812666150630183511


Synthesis and Antimicrobial Evaluation of Amphipathic Peptide Models

, 2016; 13(7): 715-724.

Marianna Sakka, Alexandra Balliou, Asimina Marianou, Dimitris Krikorian, Margarita Tsirogianni, Artemis Tsiligianni, Katerina Vartzeli, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou- Pomonis


DOI: 10.2174/1570180813666160616122410


Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475-478.

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich


DOI: 10.2174/1570180812666151022221805


Design, Synthesis and Mode of Action of Some New 2-(4'-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents

, 2016; 13(5): 429-437.

Meenakshi Singh, Sudhir Kumar Singh, Mayank Gangwar, Satheeshkumar Sellamuthu, Gopal Nath and Sushil K. Singh


DOI: 10.2174/1570180812666150821003220



Design and Synthesis of Novel Spiro-Piperidinyl Pyrazolone Derivatives and Their Potential Antiviral Activity

, 2016; 13(2): 149-160.

Rajagopalan Srinivasan, Badiadka Narayana, Balladka Kunhanna Sarojini, Veerakyathappa Bhanuprakash, Chenna Govindaraju Darshan Raj and Prakash S. Nayak


DOI: 10.2174/1570180812666150630182740



Most Accessed Articles

Synthesis and Cytotoxicity Evaluation of Novel Tricyclic Dihydropyrazolo [4,3-f][1,2,3]triazolo Diazepines

, 2018; 15(10): 1020-1025.

Chiranjeevi Bingi, Ashok Kale, Yedla Poornachandra, Chityal Ganesh Kumar and Krishnaiah Atmakur*


DOI: 10.2174/1570180815666180222143229



Synthesis of New Thiazolyl-Pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects

, 2018; 15(7): 744-756.

Belgin Sever, Mehlika Dilek Altıntop, Hulya Karaca Gencer, Handan Acelya Kapkac, Ozlem Atli, Merve Baysal and Ahmet Ozdemir*


DOI: 10.2174/1570180814666170925152902



Antimicrobial Activities of Synthetic Arylidine Nicotinic and Isonicotinic Hydrazones

, 2018; 15(10): 1057-1067.

Muhammad Hayat, Khalid Mohammed Khan*, Sumayya Saeed, Uzma Salar, Momin Khan, Taimoor Baig, Aqeel Ahmad, Shahnaz Parveen and Muhammad Taha


DOI: 10.2174/1570180814666170914120337


Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™

, 2010; 7(6): 446-451.

Alexandre Vasilevich Ivachtchenko, Eugene Borisovich Frolov, Oleg Dmitrievich Mitkin, Sergey Evgenevich Tkachenko and Alexandre Khvat


DOI: 10.2174/157018010791306579


Synthesis and Antibacterial/Antitubercular/Antioxidant Activities of Compounds Containing Fluoroquinolone Ring Linked to a 4-thiazolidinone Moiety

, 2018; 15(10): 1087-1094.

Tejeswara Rao Allaka, Naresh Kumar Katari, Venkanna Banothu, Srinubabu Maddela, Manojit Pal* and Jaya Shree Anireddy*


DOI: 10.2174/1570180815666171229150032


Synthesis and In Vitro Evaluation of Novel 1, 2, 4-Triazole Derivatives as Antifungal Agents

, 2010; 7(1): 46-49.

Ganesh R. Kokil, Prarthana V. Rewatkar, Sandeep Gosain, Saurabh Aggarwal, Arunima Verma, Atin Kalra and Suresh Thareja


DOI: 10.2174/157018010789869415



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