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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access
Order Your Article Before PrintSubscribe to this Journal

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of the latest Internet technology for both the submission and review of manuscripts. The journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

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Volume 17

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Number 7



Biography   Open Access



Research Article



Research Article

Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies

, 17(7): 840 - 849

Mahendra Gowdru Srinivas, Prabitha Prabhakaran, Subhankar Probhat Mandal, Yuvaraj Sivamani, Pranesh Guddur and Bommenahally Ravanappa Prashantha Kumar*


DOI: 10.2174/1570180816666191105124535


Research Article



Research Article



Research Article



Research Article

Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel C (7) Modified Analogues of Chrysin

, 17(7): 873 - 883

Pulabala Ramesh, Vankadari Srinivasa Rao, Puchakayala Muralidhar Reddy*, Katragadda Suresh Babu and Mutheneni Srinivasa Rao


DOI: 10.2174/1570180816666190913183623


Research Article



Letters in Drug Design & Discovery, Volume 17 (2020) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: an In silico Approach


Pooja Siniprasad, Bhagyalakshmi Nair, Vaisali Balasubramaniam, Prashanth Sadanandan, Puliyapally Krishnan Krishnan Namboori and Lekshmi Reghu Nath*


DOI: 10.2174/1570180817999200623115703
View Abstract





Evaluating phenyl propanoids isolated from citrus medica as potential inhibitors for mitotic kinesin Eg5


Himesh Makala*, Venkatasubramanian Ulaganathan, Aravind Sivasubramanian, Narendran Rajendran and Shankar Subramanian


DOI: 10.2174/1570180817999200630125449
View Abstract




Design, Synthesis, Docking and Computational Pharmacokinetic Profiling of New Pyrazolinyl Thiazolinone Biheterocycles as Potent Antimicrobial Agents


Vinutha Vittala Salian, Badiadka Narayana*, Balladka Kunhanna Sarojini, Sharath Chandra Kodandoor and Anupam Glorious Lobo


DOI: 10.2174/1570180817999200623115049
View Abstract




Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice





Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines

, 2020; 17(2): 104 - 113

Hui Zhao, Xiaoxia Hu, Yue Zhang, Chunlei Tang* and Bainian Feng*


DOI: 10.2174/1570180815666181017120100



Targeting Inflammation with Conjugated Cinnamic Amides, Ethers and Esters

, 2020; 17(1): 3 - 11

Ioannis Fotopoulos, Eleni Pontiki and Dimitra Hadjipavlou Litina*


DOI: 10.2174/1570180816666181129125511




Molecular Modeling of an Orphan GPR18 Receptor

, 2019; 16(10): 1167 - 1174

Kamil J. Kuder, Tadeusz Karcz, Maria Kaleta and Katarzyna Kiec-Kononowicz*


DOI: 10.2174/1570180815666180810114847



The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen


DOI: 10.2174/1570180816666181122122655



Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

, 2019; 16(8): 882 - 891

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu


DOI: 10.2174/1570180815666180803124625



Open Access Articles

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *




A Series of Furan-based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity

, 2020; 17(3): 312 - 322

Mehlika Dilek Altintop*, Belgin Sever, Özlem Atli Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir




Synthesis of Piperidine Conjugated Dihydroquinazolin-4(1H)-ones and their Antiproliferative Activity, Molecular Docking Studies and DFT Calculations

, 2020; 17(1): 85 - 93

Kereyagalahally Honneshappa Narasimhamurthy, Chandra, Toreshettahally Ramesh Swaroop, Swamy Jagadish and Kanchugarakoppal Subbegowda Rangappa*




Synthesis and Analgesic Activity of Monoterpenoid Aldehyde-derived Hydro-2H-chromeneols

, 2020; 17(1): 68 - 78

Irina Il'ina*, Ekaterina Morozova, Dina Korсhagina, Konstantin Volсho, Tat'yana Tolstikova and Nariman Salakhutdinov




Identifying the Structural Features of Diphenyl Ether Analogues for InhA Inhibition: A 2D and 3D QSAR Based Study

, 2020; 17(1): 31 - 47

Ashutosh Prasad Tiwari, Varadaraj Bhat Giliyar*, Gurypur Gautham Shenoy and Vandana Kalwaja Eshwara




Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

, 2019; 16(12): 1387 - 1394

Mark Gallant Fulton, Matthew Thomas Loch, Caroline Anne Cuoco, Alice Lambert Rodriguez, Emily Days, Paige Newton Vinson, Krystian Andrezej Kozek, Charles David Weaver, Anna Louise Blobaum, Peter Jeffrey Conn, Colleen Marie Niswender* and Craig William Lindsley*




Antitumor Activity of Cyclodextrin-based Supramolecular Platinum Prodrug In vitro and In vivo

, 2019; 16(11): 1296 - 1301

Yu-Hui Zhang, Jie Wang, Siqintana Xin, Li-Juan Wang and Xianliang Sheng*




Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions

, 2019; 16(11): 1248 - 1257

Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich





Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies

, 2019; 16(9): 994 - 1005

Naveen Kumar, Swamy Sreenivasa*, Bhuvanesh Sukhlal Kalal, Vasantha Kumar, Bantwal Shivarama Holla, Vinitha Ramanath Pai, Nadigar Revansiddappa Mohan and Shivaraj Govindaiah




The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen






In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration

, 2019; 16(8): 948 - 960

Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*




Synthesis, Anti-inflammatory, Antimicrobial Potential and Molecular Docking Studies of 4,5-Disubstituted-1,2,4-Triazole Thioacetate Derivatives

, 2019; 16(7): 734 - 745

Muhammad Nouman Arif, Humaira Nadeem*, Rehan Zafar Paracha, Arif-ullah Khan, Muhammad Imran and Fawad Ali





Most Cited Articles

Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*


DOI: 10.2174/1570180815666180704103047


Research Article

Novel 1,3,4-oxadiazole fused thiadiazole derivatives: Synthesis and study of anticancer activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*


DOI: 10.2174/1570180816666181031125946


Research Article

(Substituted)-benzo[b]thiophene-4-carboxamide synthesis and antiproliferative activity study

, 2020; 17(5): 563-573.

Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*


DOI: 10.2174/1570180815666181004114125


Research Article

Design, synthesis and cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids as potent anti-breast cancer agents

, 2019; 16(7): 818-824.

Maryam Mohammadi-Khanaposhtani, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi and Tahmineh Akbarzadeh*


DOI: 10.2174/1570180815666180627121006



Research Article

Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin B<inf>6</inf> and different heteroaromatic nucleus

, 2019; 16(7): 792-798.

Thais Cristina Mendonça Nogueira, Lucas dos Santos Cruz, Maria Cristina Lourenço and Marcus Vinicius Nora de Souza*


DOI: 10.2174/1570180815666180627122055


Research Article

N-acetylserotonin vs melatonin: In-vitro controlled release from hydrophilic matrix tablets

, 2019; 16(3): 347-352.

M. Vlachou*, G. Stavrou, A. Siamidi, S. Flitouri, V. Ioannidou and S. Mavrokordopoulos


DOI: 10.2174/1570180815666180404125519


Research Article

Evaluation of the in vitro antitumor activity of nanostructured cyclotides in polymers of Eudragit<sup>®</sup> L 100-55 and RS 30 D

, 2019; 16(4): 437-445.

Osmar N. Silva, Michelle F.S. Pinto, Juliane F.C. Viana, Camila G. Freitas, Isabel C.M. Fensterseifer, David J. Craik and Octavio L. Franco*


DOI: 10.2174/1570180815666180801115526



Research Article

Synthesis, anti-proliferative evaluation, and molecular docking studies of 3-(Alkylthio)-5,6-diaryl-1,2,4-triazines as tubulin polymerization inhibitors

, 2019; 16(11): 1194-1201.

Farhad Saravani, Ebrahim Saeedian Moghadam, Hafezeh Salehabadi, Seyednasser Ostad, Morteza Pirali Hamedani, Massoud Amanlou, Mohammad Ali Faramarzi and Mohsen Amini*


DOI: 10.2174/1570180815666180727114216


Research Article

A study on the synthesis of risedronic acid: The role of an ionic liquid additive

, 2019; 16(3): 238-244.

Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*


DOI: 10.2174/1570180815666180626122630


Research Article

New 2-oxopyridine/2-thiopyridine derivatives tethered to a benzotriazole with cytotoxicity on MCF7 cell lines and with antiviral activities

, 2020; 17(2): 124-137.

Adel Mahmoud Attia, Ahmed Ibrahin Khodair*, Eman Abdelnasser Gendy, Mohammed Abu El-Magd and Yaseen Ali Mosa Mohamed Elshaier*


DOI: 10.2174/1570180816666190220123547


Research Article

Antimicrobial activity, antioxidant properties and phytochemical screening of aesculus hippocastanum mother tincture against food-borne bacteria

, 2020; 17(1): 48-56.

Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso and Giovanni Salzano


DOI: 10.2174/1570180816666181108114115


Letter

One-pot synthesis of betulin triterpenoid quaternized pyridine derivatives and their antimicrobial activity

, 2020; 17(1): 79-84.

Elvira Rifovna Shakurova, Darina Alexandrovna Pozdnyakova, Elena Valeryevna Tretyakova and Lyudmila Vyacheslavovna Parfenova*


DOI: 10.2174/1570180816666181217123629


Letter

Molecular modeling of an orphan GPR18 receptor

, 2019; 16(10): 1167-1174.

Kamil J. Kuder, Tadeusz Karcz, Maria Kaleta and Katarzyna Kiec-Kononowicz*


DOI: 10.2174/1570180815666180810114847



Most Accessed Articles


New Hybrids Derived from the Natural Compound (-)-β-Pinene and Amides or Acylthioureas as Antitumor Agents

, 2020; 17(3): 271-284.

Shengliang Liao, Xiaoping Rao, Minggui Shen, Hongyan Si, Jie Song, Shibin Shang* and Zhanqian Song*


DOI: 10.2174/1570180816666181107094427


A Series of Furan-based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity

, 2020; 17(3): 312-322.

Mehlika Dilek Altintop*, Belgin Sever, Özlem Atli Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir


DOI: 10.2174/1570180816666190325163948




Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties

, 2020; 17(3): 285-299.

Chengshu Jia, Bin Hu, Yingying Ji, Yourui Su, Guoqing Gong, Qihua Zhu and Yungen Xu*


DOI: 10.2174/1570180816666181113102359


Targeting Inflammation with Conjugated Cinnamic Amides, Ethers and Esters

, 2020; 17(1): 3-11.

Ioannis Fotopoulos, Eleni Pontiki and Dimitra Hadjipavlou Litina*


DOI: 10.2174/1570180816666181129125511


Drug Discovery of Acetophenone Derivatives as BRD4 Inhibitors

, 2020; 17(3): 323-329.

Zhimin Zhang, Wenhai Huang, Xiaoliang Zheng, Chuansheng Li and Zhengrong Shen*


DOI: 10.2174/1570180816666190329223559


Synthesis and Antimicrobial Activity of Thiohydantoins Obtained from L-Amino Acids

, 2020; 17(1): 94-102.

Priscila Goes Camargo de Carvalho, Jhonatan Macedo Ribeiro, Renata Perugini Biasi Garbin, Gerson Nakazato, Sueli Fumie Yamada Ogatta, Ângelo de Fátima, Marcelle de Lima Ferreira Bispo and Fernando Macedo*


DOI: 10.2174/1570180816666181212153011



Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)
Biography View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.05

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