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Letters in Drug Design & Discovery

Volume 18, 12 Issues, 2021
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of the latest Internet technology for both the submission and review of manuscripts. The journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

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Volume 18

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Number 5



Biography   Open Access



Perspective Article

Chitosan: A Promising Protective Component Against SARS-CoV-2 and Influenza Virus

, 18(5): 418 - 421

Mohammad Reza Rahbar, Hadi Esmaeili Gouvarchin Galeh, Saeed Khalili and Abolfazl Jahangiri*


DOI: 10.2174/1570180817999201110114446


Letter Article





Letter Article

Design and Synthesis of Novel 5-Arylisoxazole-1,3,4-thiadiazole Hybrids as α-Glucosidase Inhibitors

, 18(5): 436 - 444

Mina Saeedi, Azadeh Eslami, Seyedeh Sara Mirfazli, Mahsa Zardkanlou, Mohammad Ali Faramarzi, Mohammad Mahdavi and Tahmineh Akbarzadeh*


DOI: 10.2174/1570180817999201104125018


Research Article

Bioactive Isolates of Morus Species as Antibacterial Agents and their In Silico Profiling

, 18(5): 445 - 453

Aditya Shimoga Janakirama Rao*, Venugopal Thegur Mudduraj Urs, Jayanna Nayakarahatty Devanna, Paramesha Mahadevappa and Ramesh Chapeyil Kumaran


DOI: 10.2174/1570180817999201104120815




Research Article

Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules

, 18(5): 461 - 470

Aslıhan Kurt-Kızıldoğan, Çiğdem Otur, Can Yılmaz, Sevki Arslan, Dogukan Mutlu, Arif Kivrak*, Muheb Algso, Abdussamet Kayhan, Doğan Çetin and Metin Konus*


DOI: 10.2174/1570180817999201109203226


Articles Ahead of Print


Investigating the Mechanism of Action of Frankincense against Drug- Induced Liver Injury Using Network Pharmacology and Molecular Docking


Yu-cheng Liao, Jing-wen Wang, Qian Yang, Wen-jun Wanga, Chao Zhao, Lian Sun, Ai-dong Wen*, Rui-li Li* and Yi Ding*


DOI: 10.2174/1570180818666210319160217
View Abstract










Abstracts Ahead of Print








Design and synthesis of tri-substituted imidazole derivatives as CD73 inhibitors for their anticancer activity


Abhishek Ghara*, Ganesh Sakharam Andhale, Gurubasavaraja Swamy Purawarga Matada and Prasad Sanjay Dhiwar


DOI: 10.2174/1570180818666210604113849
View Abstract



Design of Oleanolic Acid-Based Hybrid Compounds as Potential Pharmaceutical Scaffolds


Vuyolwethu Khwaza, Opeoluwa Oyehan Oyedeji, Blessing Atim Aderibigbe*, Eric Morifi, Youmbi Thierry Fonkui, Derek Tantoh Ndinteh, Margo Nell and Vanessa Steenkamp


DOI: 10.2174/1570180818666210604112451
View Abstract


Published Contents

Editor's Choice

Chitosan: A Promising Protective Component Against SARS-CoV-2 and Influenza Virus

, 2021; 18(5): 418 - 421

Mohammad Reza Rahbar, Hadi Esmaeili Gouvarchin Galeh, Saeed Khalili and Abolfazl Jahangiri*


DOI: 10.2174/1570180817999201110114446




Expanding Opportunities in Treatment of Leukemia by Solid Lipid Nanoparticles

, 2021; 18(3): 212 - 221

Prarthna Yadav, Harshita Mishra, Manju Nagpal and Geeta Aggarwal*


DOI: 10.2174/1570180817999201001155508



Sulfonamides and Sulphonyl Ester of Quinolines as Non-Acidic, Non- Steroidal, Anti-inflammatory Agents

, 2021; 18(2): 112 - 120

Bilquees Bano, Kanwal, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Muhammad Taha, Syed Moazzam Haider and Shahnaz Perveen


DOI: 10.2174/1570180817999201005201308




Novel Coronavirus 2019 Outbreak: A Global Epidemic

, 2020; 17(12): 1458 - 1464

Sweta Kamboj*, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Rohit Dutt


DOI: 10.2174/1570180817999200802033916



Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach

, 2020; 17(11): 1401 - 1408

Pooja Siniprasad, Bhagyalakshmi Nair, Vaisali Balasubramaniam, Prashanth Sadanandan, Puliyapally Krishnan Namboori* and Lekshmi Reghu Nath*


DOI: 10.2174/1570180817999200623115703



Anti-inflammatory Augmentation Therapy in Obsessive-compulsive Disorder: A Review

, 2020; 17(10): 1198 - 1205

Hanie Ghasemi, Homa Nomani, Amirhossein Sahebkar* and Amir Hooshang Mohammadpour*


DOI: 10.2174/1570180817999200520122910





Open Access Articles




Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *




Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure

, 2020; 17(6): 772 - 786

Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*




Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character

, 2020; 17(6): 731 - 744

Csilla Sepsey Für, Gergő Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*




Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

, 2020; 17(6): 725 - 730

Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*




Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives

, 2020; 17(6): 713 - 724

Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*




Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury

, 2020; 17(6): 676 - 683

Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li*




Azacyanines as Novel Topoisomerase II Alpha Inhibitors

, 2020; 17(5): 666 - 671

Sercan Guloglu, Fahriye Nur Kirmaci, Özgül Persil Çetinkol*, Mehrdad Forough and Aybuke Gulkaya




Microwave-assisted Synthesis and Docking Studies of Phenylureas as Candidates for the Drug Design Against the Biological Warfare Agent Yersinia Pestis

, 2020; 17(5): 633 - 639

Tanos Celmar Costa França*, Leonardo da Costa Bastos, Teobaldo Cuya, Mehdi Sirouspour, Franklin Chacón-Huete, David Bendahan and Pat Forgione*





Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone

, 2020; 17(4): 512 - 517

Ognyan Ivanov Petrov, Yordanka Borisova Ivanova*, Mariana Stefanova Gerova and Georgi Tsvetanov Momekov




New Hydrazone Derivatives of Pyrazole-4-carboxaldehydes Exhibited Anti-inflammatory Properties

, 2020; 17(4): 502 - 511

Mingxia Song, Bing Liu, Shengwang Yu, Shihui He, Yuqiu Liang, Sifan Li, Qiuyan Chen and Xianqing Deng*




In Silico Elucidation of the Molecular Recognition of Phenol Derivative Compounds and Hippuryl-histidyl-leucine as an Artificial Substrate with the Experimental Target: Angiotensin-converting Enzyme

, 2020; 17(4): 445 - 466

Víctor Hugo Vázquez-Valaldez*, Manuel Alejandro Hernández S, Ivonne Carrillo Cedillo, Ana María Velázquez Sanchez, Mildred Sauce Guevara, Rafael López Castañares and Enrique Ángeles





Most Cited Articles

Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*


DOI: 10.2174/1570180815666180704103047


Research Article

Novel 1,3,4-oxadiazole fused thiadiazole derivatives: Synthesis and study of anticancer activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*


DOI: 10.2174/1570180816666181031125946



Research Article

(Substituted)-benzo[b]thiophene-4-carboxamide synthesis and antiproliferative activity study

, 2020; 17(5): 563-573.

Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*


DOI: 10.2174/1570180815666181004114125


Research Article

Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin B<inf>6</inf> and different heteroaromatic nucleus

, 2019; 16(7): 792-798.

Thais Cristina Mendonça Nogueira, Lucas dos Santos Cruz, Maria Cristina Lourenço and Marcus Vinicius Nora de Souza*


DOI: 10.2174/1570180815666180627122055


Research Article

Synthesis, anti-proliferative evaluation, and molecular docking studies of 3-(Alkylthio)-5,6-diaryl-1,2,4-triazines as tubulin polymerization inhibitors

, 2019; 16(11): 1194-1201.

Farhad Saravani, Ebrahim Saeedian Moghadam, Hafezeh Salehabadi, Seyednasser Ostad, Morteza Pirali Hamedani, Massoud Amanlou, Mohammad Ali Faramarzi and Mohsen Amini*


DOI: 10.2174/1570180815666180727114216



General Research Article

The development of tyrosyl-DNA phosphodyesterase 1 (TDP1) inhibitors based on the amines combining aromatic/heteroaromatic and monoterpenoid moieties

, 2019; 16(5): 597-605.

Evgenii Mozhaitsev, Evgenii Suslov*, Yuliya Demidova, Dina Korchagina, Konstantin Volcho, Alexandra Zakharenko, Inna Vasil'eva, Maksim Kupryushkin, Arina Chepanova, Daniel Moscoh Ayine-Tora, Jóhannes Reynisson, Nariman Salakhutdinov and Olga Lavrik


DOI: 10.2174/1570180816666181220121042


Research Article

Design, synthesis and cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids as potent anti-breast cancer agents

, 2019; 16(7): 818-824.

Maryam Mohammadi-Khanaposhtani, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi and Tahmineh Akbarzadeh*


DOI: 10.2174/1570180815666180627121006


Research Article

Synthesis, characterization, free-radical scavenging capacity and antioxidant activity of novel series of hydrazone, 1,3,4-oxadiazole and 1,2,4-triazole derived from 3,5-dimethyl-1H-pyrazole

, 2019; 16(7): 712-720.

Khalid Karrouchi*, Saad Fettach, Smaail Radi*, El bekkaye Yousfi, Jamal Taoufik, Yahia Nasser Mabkhot, Seham Alterary, My El Abbes Faouzi and Muhammed Ansar


DOI: 10.2174/1570180815666180516103050


General Research Article

Novel tri-substituted thiazoles bearing piperazine ring: Synthesis and evaluation of their anticancer activity

, 2019; 16(5): 547-555.

Asaf Evrim Evren*, Leyla Yurttaş , Busra Eksellı and Gulsen Akalın-Cıftcı


DOI: 10.2174/1570180815666180731122118


Research Article

New 2-oxopyridine/2-thiopyridine derivatives tethered to a benzotriazole with cytotoxicity on MCF7 cell lines and with antiviral activities

, 2020; 17(2): 124-137.

Adel Mahmoud Attia, Ahmed Ibrahin Khodair*, Eman Abdelnasser Gendy, Mohammed Abu El-Magd and Yaseen Ali Mosa Mohamed Elshaier*


DOI: 10.2174/1570180816666190220123547


Research Article

Antimicrobial activity, antioxidant properties and phytochemical screening of aesculus hippocastanum mother tincture against food-borne bacteria

, 2020; 17(1): 48-56.

Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso and Giovanni Salzano


DOI: 10.2174/1570180816666181108114115


Review Article

Potential of nanoparticles in combating Candida infections

, 2019; 16(5): 478-491.

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224




Most Accessed Articles

Design and Efficient Synthesis of Novel 4,5-Dimethylthiazole-Hydrazone Derivatives and their Anticancer Activity

, 2021; 18(4): 372-386.

Asaf Evrim Evren*, Leyla Yurttaş, Büşra Ekselli, Onur Aksoy and Gülşen Akalin-Çiftçi


DOI: 10.2174/1570180817999201022192937


Chitosan: A Promising Protective Component Against SARS-CoV-2 and Influenza Virus

, 2021; 18(5): 418-421.

Mohammad Reza Rahbar, Hadi Esmaeili Gouvarchin Galeh, Saeed Khalili and Abolfazl Jahangiri*


DOI: 10.2174/1570180817999201110114446


Novel N-(2-Methoxydibenzofuran-3-yl)-2-aryloxyacetamide Derivatives: Synthesis and Biological Investigation

, 2021; 18(5): 471-479.

Leyla Yurttaş*, Betül Kaya Çavuşoğlu, Halide Edip Temel and Gülşen Akalın Çiftçi


DOI: 10.2174/1570180817999201110114107



Bioactive Isolates of Morus Species as Antibacterial Agents and their In Silico Profiling

, 2021; 18(5): 445-453.

Aditya Shimoga Janakirama Rao, Venugopal Thegur Mudduraj Urs, Jayanna Nayakarahatty Devanna, Paramesha Mahadevappa and Ramesh Chapeyil Kumaran*


DOI: 10.2174/1570180817999201104120815


Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules

, 2021; 18(5): 461-470.

Aslıhan Kurt-Kızıldoğan, Çiğdem Otur, Can Yılmaz, Sevki Arslan, Dogukan Mutlu, Arif Kivrak*, Muheb Algso, Abdussamet Kayhan, Doğan Çetin and Metin Konus*


DOI: 10.2174/1570180817999201109203226


Novel Carbamοyloxy Analogues of Tamoxifen: Synthesis, Molecular Docking and Bioactivity Evaluation

, 2021; 18(5): 422-428.

Konstantinos M. Kasiotis*, George Lambrinidis, Nikolas Fokialakis and Serkos A. Haroutounian


DOI: 10.2174/1570180817999201104125630




Virtual Screening of Chinese Medicine Small Molecule Compounds Targeting SARS-CoV-2 3CL Protease (3CL pro)

, 2021; 18(4): 355-364.

Qingxiu He, Xin Chen, Xi Yang, Guangpin Li, Haiqiong Guo, Han Chu, Zhihua Lin* and Yuanqiang Wang*


DOI: 10.2174/1570180817999201001161017



Design and Synthesis of Novel 5-Arylisoxazole-1,3,4-thiadiazole Hybrids as α-Glucosidase Inhibitors

, 2021; 18(5): 436-444.

Mina Saeedi, Azadeh Eslami, Seyedeh Sara Mirfazli, Mahsa Zardkanlou, Mohammad Ali Faramarzi, Mohammad Mahdavi and Tahmineh Akbarzadeh*


DOI: 10.2174/1570180817999201104125018







Editor-in-Chief

graphic
Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)
Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.

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