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Letters in Drug Design & Discovery

Volume 16, 12 Issues, 2019
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

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  • 57th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

,

Volume 16

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Number 12



Biography   Open Access



Review Article



Research Article



Research Article



Research Article



Research Article



Research Article



Research Article

Synthesis and Antimicrobial Activity of Adamantyl Substituted Pyridoxine Derivatives

, 16(12): 1360 - 1369

Rail Khaziev, Nikita Shtyrlin, Roman Pavelyev, Raushan Nigmatullin, Raylya Gabbasova, Denis Grishaev, Anna Shtro, Anastasia Galochkina , Yulia Nikolaeva , Tatiana Vinogradova , Olga Manicheva, Marine Dogonadze, Oleg Gnezdilov , Evgeny Sokolovich, Petr Yablonskiy, Konstantin Balakin and Yurii Shtyrlin*


DOI: 10.2174/1570180816666190911150705


Letters in Drug Design & Discovery, Volume 17 (2020) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Understanding the Binding Mechanism of Anti-antagonist (AZD3293) Against BACE-1: Molecular Insights into Alzheimer’s Drug Discovery


Sphelele Sosibo, Daniel Gyamfi Amoako, Anou Moise Somboro, Darren Delai Sun, Jane Catherine Ngila and Hezekiel Kumalo*


DOI: 10.2174/1570180816666191029142640
View Abstract





In Silico Elucidation of the Molecular Recognition of Phenol Derivative Compounds and Hippuryl-Histidyl-Leucine as an Artificial Substrate with the Experimental Target: Angiotensin-Converting Enzyme


Víctor H. Vázquez-Valaldez*, Manuel Alejandro HernándezS, Ivonne Carrillo C, Ana María VelázquezS, Mildred SauceG, Rafael López Castañares and E. Ángeles


DOI: 10.2174/1570180816666190906155034
View Abstract


Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model


Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *


DOI: 10.2174/1570180816666191024102231
View Abstract






Published Contents

Editor's Choice


Molecular Modeling of an Orphan GPR18 Receptor

, 2019; 16(10): 1167 - 1174

Kamil J. Kuder, Tadeusz Karcz, Maria Kaleta and Katarzyna Kiec-Kononowicz*


DOI: 10.2174/1570180815666180810114847



The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen


DOI: 10.2174/1570180816666181122122655



Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

, 2019; 16(8): 882 - 891

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu


DOI: 10.2174/1570180815666180803124625





Potential of Nanoparticles in Combating Candida Infections

, 2019; 16(5): 478 - 491

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224





Synthesis and Antichlamydial Activity of Novel Phenazines

, 2019; 16(2): 174 - 181

Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang* and Yu Zhao*


DOI: 10.2174/1570180815666180518112952



Open Access Articles

Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

, 2019; 16(12): 1387 - 1394

Mark Gallant Fulton, Matthew Thomas Loch, Caroline Anne Cuoco, Alice Lambert Rodriguez, Emily Days, Paige Newton Vinson, Krystian Andrezej Kozek, Charles David Weaver, Anna Louise Blobaum, Peter Jeffrey Conn, Colleen Marie Niswender* and Craig William Lindsley*




Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions

, 2019; 16(11): 1248 - 1257

Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich





Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies

, 2019; 16(9): 994 - 1005

Naveen Kumar, Swamy Sreenivasa*, Bhuvanesh Sukhlal Kalal, Vasantha Kumar, Bantwal Shivarama Holla, Vinitha Ramanath Pai, Nadigar Revansiddappa Mohan and Shivaraj Govindaiah




The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen






In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration

, 2019; 16(8): 948 - 960

Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*





Design and Synthesis of Novel Thiosemicarbazones as Potent Anti-breast Cancer Agents

, 2019; 16(4): 446 - 452

Mashooq Ahmad Bhat*, M. Al-Tahhan, Mohamed A. Al-Omar, Ahmed M. Naglah and Abdullah Al-Dhfyan




A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive

, 2019; 16(3): 238 - 244

Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*




Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2019; 16(2): 102 - 110

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




A Series of Furan-Based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity

, 2019; 16: 1 - 11 (E-Pub Ahead of Print)

Mehlika Dilek Altıntop*, Belgin Sever, Özlem Atlı Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir




Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid

, 2018; 15(7): 713 - 720

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737 - 742

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*





Most Cited Articles

Research Article

Synthesis and mosquiticidal activity of novel hydrazone containing pyrimidine derivatives against aedes aegypti

, 2018; 15(9): 951-956.

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep , David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640


Research Article

Synthesis, nematicidal activity and docking study of novel pyrazole-4-carboxamide derivatives against meloidogyne incognita

, 2018; 16(1): 29-35.

Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng* and Xing-Hai Liu*


DOI: 10.2174/1570180815666180326150827


Research Article

Computational approach to the discovery of phytochemical molecules with therapeutic potential targets to the PKCZ protein

, 1 May 2018; 15(5): 488-499.

Poliany G. Freitas*, Thiago C. Elias, Icaro A. Pinto, Luciano T. Costa, Paulo V.S.D. de Carvalho, Daniel de Q. Omote, Ihosvany Camps, Tati Ishikawa, Helen A. Arcuri, Susana Vinga, Arlindo L. Oliveira, Walter F.A. Junior and Nelson J.F. da Silveira


DOI: 10.2174/1570180814666170810120150


Research Article

Synthesis and antifungal activity of some 6-tert-butyl-8-chloro-2, 3-dimethylquinolin-4-ol derivatives against Pyricularia oryae

, 2018; 15(12): 1314-1318.

Yue-Ming Fang, Rui-Rui Zhang, Zhong-Hua Shen, Cheng-Xia Tan, Jian-Quan Weng, Tian-Ming Xu*, Xing-Hai Liu*, Hong-Ying Huang and Hong-Ke Wu


DOI: 10.2174/1570180815666180313121735


Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*


DOI: 10.2174/1570180815666180704103047


Research Article

Synthesis, biological evaluation and docking studies of 1,3,4-oxadiazole fused benzothiazole derivatives for anticancer drugs

, 2018; 15(12): 1299-1307.

Madala Subramanyam, Reddymasu Sreenivasulu, Rambabu Gundla, Mandava V.B. Rao and Koya Prabhakara Rao *


DOI: 10.2174/1570180815666180219165119



Research Article

Biological activities and docking studies on novel bis 1,4-DHPS linked to arene core via ether or ester linkage

, 2018; 15(10): 1036-1045.

Nada S. Ibrahim, Magda F. Mohamed, Ahmed H. M. Elwahy* and Ismail A. Abdelhamid*


DOI: 10.2174/1570180815666180105162323


Research Article

Novel azole-functionalited flouroquinolone hybrids: Design, conventional and microwave irradiated synthesis, evaluation as antibacterial and antioxidant agents

, 2018; 15(1): 46-64.

Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz


DOI: 10.2174/1570180814666170823163540


Research Article

Design, synthesis, and screening of hybrid benzothiazolyl-oxadiazoles as anticonvulsant agents

, 1 April 2018; 15(4): 398-405.

Sheikh Murtuja, Mohammad Shaquiquzzaman and Mohammad Amir*


DOI: 10.2174/1570180814666170526154914


Research Article

Synthesis and antioxidant evaluation of a new class of thienopyrimidinerhodanine hybrids

, 1 February 2018; 15(2): 118-126.

Kerru Nagaraju , Venkata H.S.S. Bhaskaruni, Ravada Kishore , Suresh Maddila*, Parvesh Singh and Sreekantha B. Jonnalagadda


DOI: 10.2174/1570180814666170710161844


Research Article

Arginine- and lysine-rich peptides: Synthesis, characterization and antimicrobial activity

, 2018; 15(3): 220-226.

Adriano Mollica*, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Stefano Morosetti, Pasqualina Punzi and Sako Mirzaie


DOI: 10.2174/1570180814666170213161341


Letter

Synthesis, characterization and evaluation of gemfibrozil-stilbene hybrid as antioxidant agent

, 2018; 15(11): 1230-1238.

Rosa Amoroso, Lidia Leporini, Ivana Cacciatore, Lisa Marinelli, Alessandra Ammazzalorso, Isabella Bruno, Barbara De Filippis, Marialuigia Fantacuzzi, Cristina Maccallini, Luigi Menghini, Antonio Di Stefano and Letizia Giampietro*


DOI: 10.2174/1570180815666180321163246



Research Article

Microwave-assisted synthesis and antifungal activity of novel 1,2,4-triazole thioether derivatives containing pyrimidine moiety

, 1 April 2018; 15(4): 347-352.

Meng Xu, Ya-Bo Zhu, Mei Wang, Ikhlas A. Khan, Xing-Hai Liu and Jian-Quan Weng*


DOI: 10.2174/1570180814666170602082440



Most Accessed Articles

Design, Synthesis and Anti Colon Cancer Activity Evaluation of Phosphorylated Derivatives of Lamivudine (3TC)

, 2011; 8(1): 59-64.

Valasani Koteswara Rao, Sanapalli S. Reddy, Balam S. Krishna, Cirandur S. Reddy, Nimmanapalli P. Reddy, Tamatam C.M. Reddy, Chamarthi N. Raju and S. K. Ghosh


DOI: 10.2174/157018011793663921



Identification of New Inhibitors of Mutant Isocitrate Dehydrogenase 2 through Molecular Similarity-based Virtual Screening

, 2019; 16(8): 861-867.

Lijun Yang, Stefan Pusch, Victoria Jennings, Tianfang Ma, Qihua Zhu, Yungen Xu, Andreas von Deimling* and Xiaoming Zha*


DOI: 10.2174/1570180815666180808094432


Synthesis, Antioxidant and Anti-inflammatory Activities of 5-((styrylsulfonyl) methyl)-1,3,4-Oxadiazol / Thiadiazol-2-amine Derivatives

, 2019; 16(11): 1233-1247.

Gundala Sravya, Ummadi Nagarjuna, Venkatapuram Padmavathi, Galla Rajitha, Sakuri Chandi priya and Adivireddy Padmaja*


DOI: 10.2174/1570180816666181102114529



Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

, 2019; 16(8): 882-891.

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu


DOI: 10.2174/1570180815666180803124625


Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions

, 2019; 16(11): 1248-1257.

Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich


DOI: 10.2174/1570180816666181106123809


Synthesis and Investigation on the Antidiabetic Effect of 3-aryl-1-(5-methylisoxazol-3-ylamino)-1-(4-nitrophenyl) Propan-1-one

, 2019; 16(8): 835-845.

Jinyu Liu, Zuwen Zhou, Jian Liu, Jufang Yan, Li Fan, Xuemei Tang, Jie Liu, Feifei Chen and Dacheng Yang*


DOI: 10.2174/1570180815666180608101529


Design, Synthesis and Pharmacological Evaluation of Novel Antiinflammatory and Analgesic O-Benzyloxime Compounds Derived From Natural Eugenol

, 2019; 16(10): 1157-1166.

Rodrigo César da Silva, Fabiano Veiga, Fabiana Cardoso Vilela, André Victor Pereira, Thayssa Tavares da Silva Cunha, Roberta Tesch, Claudio Viegas Jr., Danielle Ferreira Dias, Alexandre Giusti-Paiva, Marcia Paranho Veloso and Carlos Alberto Manssour Fraga*


DOI: 10.2174/1570180815666180620145609


Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents

, 2019; 16(7): 721-733.

Sarva Santhisudha, Gundluru Mohan, Tenkayala Sobha Rani, Peddaiahgari Vasu Govardhana Reddy and Cirandur Suresh Reddy*


DOI: 10.2174/1570180815666180606083418




Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

Biography View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
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