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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of the latest Internet technology for both the submission and review of manuscripts. The journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

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Volume 17

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Number 12



Biography   Open Access



Review Article (Mini-Review)

Novel Coronavirus 2019 Outbreak: A Global Epidemic

, 17(12): 1458 - 1464

Sweta Kamboj*, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Rohit Dutt


DOI: 10.2174/1570180817999200802033916


Letter Article



Research Article



Research Article



Research Article



Research Article



Research Article



Articles Ahead of Print








Chalcones and Bis-Chalcones Analogs as DPPH and ABTS Radical Scavengers


Adebayo Tajudeen Bale, Uzma Salar, Khalid Mohammed Khan*, Sridevi Chigurupati, Tolulope Fasina, Farman Ali, Muhammad Ali, Sitanshu Sekhar Nanda, Muhammad Taha and Shahnaz Perveen


DOI: 10.2174/1570180817999201001155032
View Abstract



Chitosan: a promising protective component against SARS-CoV-2 and influenza virus


Mohammad Reza Rahbar, Hadi Esmaeili Gouvarchin Galeh, Saeed Khalili and Abolfazl Jahangiri*


DOI: 10.2174/1570180817999201110114446
View Abstract


Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice

Novel Coronavirus 2019 Outbreak: A Global Epidemic

, 2020; 17(12): 1458 - 1464

Sweta Kamboj*, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Rohit Dutt


DOI: 10.2174/1570180817999200802033916



Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach

, 2020; 17(11): 1401 - 1408

Pooja Siniprasad, Bhagyalakshmi Nair, Vaisali Balasubramaniam, Prashanth Sadanandan, Puliyapally Krishnan Namboori* and Lekshmi Reghu Nath*


DOI: 10.2174/1570180817999200623115703



Anti-inflammatory Augmentation Therapy in Obsessive-compulsive Disorder: A Review

, 2020; 17(10): 1198 - 1205

Hanie Ghasemi, Homa Nomani, Amirhossein Sahebkar* and Amir Hooshang Mohammadpour*


DOI: 10.2174/1570180817999200520122910









Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines

, 2020; 17(2): 104 - 113

Hui Zhao, Xiaoxia Hu, Yue Zhang, Chunlei Tang* and Bainian Feng*


DOI: 10.2174/1570180815666181017120100



Open Access Articles


Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *




Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure

, 2020; 17(6): 772 - 786

Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*




Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

, 2020; 17(6): 725 - 730

Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*




Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives

, 2020; 17(6): 713 - 724

Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*




Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury

, 2020; 17(6): 676 - 683

Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li*




Azacyanines as Novel Topoisomerase II Alpha Inhibitors

, 2020; 17(5): 666 - 671

Sercan Guloglu, Fahriye Nur Kirmaci, Özgül Persil Çetinkol*, Mehrdad Forough and Aybuke Gulkaya




Microwave-assisted Synthesis and Docking Studies of Phenylureas as Candidates for the Drug Design Against the Biological Warfare Agent Yersinia Pestis

, 2020; 17(5): 633 - 639

Tanos Celmar Costa França*, Leonardo da Costa Bastos, Teobaldo Cuya, Mehdi Sirouspour, Franklin Chacón-Huete, David Bendahan and Pat Forgione*





Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone

, 2020; 17(4): 512 - 517

Ognyan Ivanov Petrov, Yordanka Borisova Ivanova*, Mariana Stefanova Gerova and Georgi Tsvetanov Momekov




New Hydrazone Derivatives of Pyrazole-4-carboxaldehydes Exhibited Anti-inflammatory Properties

, 2020; 17(4): 502 - 511

Mingxia Song, Bing Liu, Shengwang Yu, Shihui He, Yuqiu Liang, Sifan Li, Qiuyan Chen and Xianqing Deng*




In Silico Elucidation of the Molecular Recognition of Phenol Derivative Compounds and Hippuryl-histidyl-leucine as an Artificial Substrate with the Experimental Target: Angiotensin-converting Enzyme

, 2020; 17(4): 445 - 466

Víctor Hugo Vázquez-Valaldez*, Manuel Alejandro Hernández S, Ivonne Carrillo Cedillo, Ana María Velázquez Sanchez, Mildred Sauce Guevara, Rafael López Castañares and Enrique Ángeles




In vitro and In Vivo Evaluation of Quinoxaline 1,4-di-N-oxide Against Giardia lamblia

, 2020; 17(4): 428 - 433

Elizabeth Barbosa-Cabrera, Rosa Moo-Puc, Antonio Monge, Alma Delia Paz-González, Virgilio Bocanegra-García and Gildardo Rivera*





Drug Discovery of Acetophenone Derivatives as BRD4 Inhibitors

, 2020; 17(3): 323 - 329

Zhimin Zhang, Wenhai Huang, Xiaoliang Zheng, Chuansheng Li and Zhengrong Shen*





Most Cited Articles

Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*


DOI: 10.2174/1570180815666180704103047


Research Article

Novel 1,3,4-oxadiazole fused thiadiazole derivatives: Synthesis and study of anticancer activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*


DOI: 10.2174/1570180816666181031125946



Research Article

(Substituted)-benzo[b]thiophene-4-carboxamide synthesis and antiproliferative activity study

, 2020; 17(5): 563-573.

Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*


DOI: 10.2174/1570180815666181004114125


Research Article

Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin B<inf>6</inf> and different heteroaromatic nucleus

, 2019; 16(7): 792-798.

Thais Cristina Mendonça Nogueira, Lucas dos Santos Cruz, Maria Cristina Lourenço and Marcus Vinicius Nora de Souza*


DOI: 10.2174/1570180815666180627122055


Research Article

Design, synthesis and cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids as potent anti-breast cancer agents

, 2019; 16(7): 818-824.

Maryam Mohammadi-Khanaposhtani, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi and Tahmineh Akbarzadeh*


DOI: 10.2174/1570180815666180627121006


Review Article

Potential of nanoparticles in combating Candida infections

, 2019; 16(5): 478-491.

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224



Review Article

Neurokinin-1 receptor antagonists as anticancer drugs

, 2019; 16(10): 1110-1129.

Miguel Muñoz* and Rafael Coveñas


DOI: 10.2174/1570180816666190221091955


Research Article

Synthesis, characterization, free-radical scavenging capacity and antioxidant activity of novel series of hydrazone, 1,3,4-oxadiazole and 1,2,4-triazole derived from 3,5-dimethyl-1H-pyrazole

, 2019; 16(7): 712-720.

Khalid Karrouchi*, Saad Fettach, Smaail Radi*, El bekkaye Yousfi, Jamal Taoufik, Yahia Nasser Mabkhot, Seham Alterary, My El Abbes Faouzi and Muhammed Ansar


DOI: 10.2174/1570180815666180516103050


Research Article

Antimicrobial activity, antioxidant properties and phytochemical screening of aesculus hippocastanum mother tincture against food-borne bacteria

, 2020; 17(1): 48-56.

Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso and Giovanni Salzano


DOI: 10.2174/1570180816666181108114115


Letter

One-pot synthesis of betulin triterpenoid quaternized pyridine derivatives and their antimicrobial activity

, 2020; 17(1): 79-84.

Elvira Rifovna Shakurova, Darina Alexandrovna Pozdnyakova, Elena Valeryevna Tretyakova and Lyudmila Vyacheslavovna Parfenova*


DOI: 10.2174/1570180816666181217123629


Letter

Challenges in the discovery and optimization of mGLU<inf>2/4</inf> heterodimer positive allosteric modulators

, 2019; 16(12): 1387-1394.

Mark Gallant Fulton, Matthew Thomas Loch, Caroline Anne Cuoco, Alice Lambert Rodriguez, Emily Days, Paige Newton Vinson, Krystian Andrezej Kozek, Charles David Weaver, Anna Louise Blobaum, Peter Jeffrey Conn, Colleen Marie Niswender* and Craig William Lindsley*


DOI: 10.2174/1570180815666181017131349


General Research Article

The development of tyrosyl-DNA phosphodyesterase 1 (TDP1) inhibitors based on the amines combining aromatic/heteroaromatic and monoterpenoid moieties

, 2019; 16(5): 597-605.

Evgenii Mozhaitsev, Evgenii Suslov*, Yuliya Demidova, Dina Korchagina, Konstantin Volcho, Alexandra Zakharenko, Inna Vasil'eva, Maksim Kupryushkin, Arina Chepanova, Daniel Moscoh Ayine-Tora, Jóhannes Reynisson, Nariman Salakhutdinov and Olga Lavrik


DOI: 10.2174/1570180816666181220121042




Most Accessed Articles



Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787-798.

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *


DOI: 10.2174/1570180816666191024102231


Current Strategies and Approaches in Combating SARS-CoV-2 Virus that Causes COVID-19

, 2020; 17(5): 672-674.

D. Sivaraman*, P. S. Pradeep, S. Sundar Manoharan, C. Ramachandra Bhat, K. V. Leela and V. Venugopal


DOI: 10.2174/157018081705200403092546







Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)
Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.05

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