E-Pub Articles Ahead of Print ::: Letters in Drug Design & Discovery

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 14, 12 Issues, 2017


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Letters in Drug Design & Discovery

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Editor-in-Chief:
G. Perry
University of Texas
San Antonio, TX
USA


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Articles Ahead of Print

3D QSAR Studies of Tricyclic Compounds as Porcupine Inhibitors for Wnt Pathway Inhibitory Activity


Liqiang Meng, Liqian Sun, Chaoqun Yan, Dongxiao Cui, Jingrun Chen, Taigang Liang* and Qingshan Li


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Laser Modified Phenothiazines and Hydantoins: Photo-products Characterisation and Application on Animal Eyes Pseudo-tumours


Tatiana Tozar, Adriana Smarandache, Angela Staicu, Mihail Lucian Pascu* and Ruxandra Angela Pirvulescu


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Synthesis, Antioxidant and Antimicrobial Activities of Metal Complexes of 2-thiouracil-hydroxyquinoline Derivatives


Apilak Worachartcheewan*, Ratchanok Pingaew, Decha Lekcharoen, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul


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Synthesis of New Thiazolyl-Pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects


Belgin Sever, Mehlika Dilek Altıntop, Hulya Karaca Gencer, Handan Acelya Kapkac, Ozlem Atlı, Merve Baysal and Ahmet Ozdemir*


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Comparative Antioxidant Activity and Structural Feature of Protocatechuic Acid and Phenolic Acid Derivatives by DPPH and Intracellular ROS


Woong Kim, Beomgi Lee, Jaeyoung Park, Ho-Joong Kim and Hyeonsook Cheong*


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Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti


Mehlika Dilek Altıntop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asım Kaplancikli and Ahmet Ozdemir


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3D-QSAR Studies of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones Derivatives as RSV Fusion Inhibitors


Lian Liu, Yuanhao Zhai, Yiqun Chang, Wen Yan, Ruoshi Huang, Pinghua Sun, Wenzhu Huang* and Jialiang Guo*


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Synthesis, Characterization and Antibacterial Evaluation of some New 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines as Potential Antibacterial Agents


Kooi-Mow Sim* and Kah-Cheng Teo


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Highly Functionalized Tryptamine-Azole-Fluoroquinolone Hybrids: Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation


Yıldız Uygun Cebeci, Serap Basoglu Ozdemir,, Hacer Bayrak, Sule Ceylan, Ahmet Demirbas, Neslihan Demirbas* and Sengul Alpay Karaoglu


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Pharmacophore and 3D-QSAR Characterization of Thieno[3,2-d] pyrimidine-6-carboxamides as SIRT-2 Inhibitors


Neetu Agrawal*, Kamal Shah and Pradeep Mishra


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In Vitro Cytotoxic Activities of Platinum(II) Complex with 1-Methyl-2-(3′- hydroxypropyl)benzimidazole and 2-(3′-Hydroxypropyl)benzimidazolium Hexa- and Tetrachloroplatinate Salts


Gokcen Eren, Sukran Yilmaz and Fatma Gumus


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Development of Structure Activity Correlation Model on Aroylindole Derivative as Anticancer Agents


Vijay K Patel and Harish Rajak*


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In Silico Study of Flavonoids as DPP-4 and α-glucosidase Inhibitors


Jasmin Kaur, Ramit Singla and Vikas Jaitak*


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The Identification of New CD38 Inhibitors by Combined Structure and Ligand Based Virtual Screening Approaches of ZINC Database


Bakhtyar Sepehri and Raouf Ghavami*


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1, 2, 4-Oxadiazole Incorporated Ketoprofen Analogues in Search of Safer Non-steroidal Anti-inflammatory Agents: Design, Syntheses, Biological Evaluation and Molecular Docking Studies


Chanda Ranjan, Mymoona Akhter, Kalicharan Sharma, Jagdish Kumar, Anees Ahmad Siddiqui and Gita Chawla*


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Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic


Maria Matilde Ramirez Moran, Jorge Eduardo Angel*, Natividad Herrera Cano, Biagina Del Carmen Migliore, Rodolfo Izquierdo, Jaime Charris, Simón López, Anita Israel, Ana Santiago, Roberto Ross, Luis Perdomo, Akram Samear Dabian, Mariagracia Vera, Alejandra Villalba and Ligia Biagina Angel Migliore


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Antiproliferative Effects of Nerium oleander Stem and Mitotic Arrest Induced by Cardenolide Odoroside B on NCI-H460 Cancer Cells


Kehkashan Arshad Qamar*, Ahsana Dar Farooq, Bina S. Siddiqui, Nurul Kabir, Naseema Khatoon, Shakil Ahmed, Shaista Erum and Sabira Begum


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QSAR Studies on NTF1836 Analogues as Mycothiol Biosynthesis Inhibitors


M. K. Kathiravan*, S. S. Nilewar and A. N. Kale


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Microwave Assisted Synthesis and Potent Antimicrobial Activity of Some Novel 1,3-dialkyl-2-arylbenzimidazolium Salts


Bilge Eren*, Özge Yilmaz, Gülçin Çetin and Cihan Darcan


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Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents


Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz


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Design, Synthesis and Biological Evaluation of a Novel Series of Indole-3- Carboxamide Derivatives for Cancer Treatment as EGFR Inhibitors


Lan Zhang, Xin-Shan Deng, Guan-Peng Meng, Chao Zhang, Cong-Chong Liu, Gu-Zhou Chen , Qing-Chun Zhao and Chun Hu*


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Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents


Ali Erguc, Mehlika Dilek Altintop*, Ozlem Atli, Belgin Sever, Gokalp Iscan, Gozde Gormus and Ahmet Ozdemir


View Abstract


Illicium verum Extract Exhibited Anti-inflammatory Action in Rodents


Shagufta Khan, Huma Aslam Bhatti, Ghulam Abbas, Muhammad Ali Versiani, Shaheen Faizi, Salman Khalid Ahmed, Saad Jawaid , Anita Naushir Akbar Ali , Rabia Jamy , Fatima Shahid and Ahsana Dar Farooq


View Abstract


Microwave-promoted Synthesis of S-substituted Quinazoline Derivatives using 1,4-dihydroquinazoline-2-thiol


Satya Karuna Pulakhandam, Naresh Kumar Katari* and Ravi Prakash Reddy Manda


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Topical Formulations and Intradermal Injections of Tranexamic Acid in the Treatment of Hyperpigmentation-A Review


Mirella Batory* and Helena Rotsztejn


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Novel Hybrid Molecules of Isoxazole Chalcone Derivatives: Synthesis and Study of in vitro Cytotoxic Activities


Arunkumar Thiriveedhi*, Ratnakaram Venkata Nadh , Navuluri Srinivasu and Kishore Kaushal


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A Comprehensive Review on Recent Developments in the Field of Biological Applications of Potent Pyrazolines Derived from Chalcone Precursors


Vinutha V. Salian, Badiadka Narayana, Balladka K. Sarojini* and Kullaiah Byrappa


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A Computational Study of Molecular Interactions and In Vitro Antibacterial Activity of 6-Substituted Quinoline Carboxylic Acid Derivatives as DNA Gyrase Inhibitors


Sonal Dubey*, Sakshi Bhardwaj, Ekta Singh, Prabitha Prabhakaran and Ayda Cherian


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In Silico Bioactivity Prediction of Methoxime-3,4-dephostatin Derivatives on Human PTP1B: Search for Novel Antidiabetic Leads


Sabina Begum Choudhury, Anupam Das Talukdar*, Manabendra Dutta Choudhury, Monjur Ahmed Laskar and Abhishek Chowdhury


View Abstract


Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica


Reham Al-Harbia, Mona I. Shaaban*, Razan Al-wegaisi, Fatma Moharram, Ola Abd El-Rahman and Shahenda El-Messery


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Design, Synthesis and Cytotoxic Activity of Spiro(oxindole-3-3'- pyrrolidine) Derivatives


Dilan Konyar*, Cenk A. Andac and Erdem Buyukbingol


View Abstract


Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives


Mehdi Asadi, Mohammad Mahdavi, Shabnam Mahernia, Zahra Rezaei, Maliheh Safavi, Mina Saeedi and Massoud Amanlou*


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Design, Synthesis, Characterization and Antitubercular Screening of some New 1,2,4-Triazoles Derived from Isonicotinic Acid Hydrazides


Vaibhav Rajoriya, Varsha Kashaw and Sushil Kumar Kashaw*


View Abstract


Computational Approach to the Discovery of Phytochemical Molecules with Therapeutic Potential Targets to the PKCZ protein


Poliany G. Freitas*, Thiago C. Elias, Icaro A. Pinto, Luciano T. Costa, Paulo VSD de Carvalho, Daniel Q. Omote, Ihosvany Camps, Tati Ishikawa, Helen A. Arcuri, Susana Vinga, Arlindo L. Oliveira, Walter F.A. Junior and Nelson J. F. da Silveira


View Abstract


Synthesis and Antimicrobial Activity of Some New N-(1H-benzimidazol-2- yl)-2-mercaptoacetamide Derivatives


Asaf Evrim Evren, Sinem Tekinkoca and Leyla Yurttas*


View Abstract


Synthesis and Evaluation of the Anticonvulsant Activities of New 5-substitued-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one Derivatives


Guo-Rui Zhang, Yang Ren, Xiu-Mei Yin and Zhe-Shan Quan*


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Design, Synthesis and Biological Evaluation of Some Novel Thiazole-2- Carboxamide Derivatives as Antitumor Agents


Haibo Wang*, Zhengjiang Cai, Shan Zheng, Huidan Ma, Haiming Lin and Xiaohe Zheng


View Abstract


Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors


Gülhan Turan-Zitouni*, Weiam Hussein, Begüm Nurpelin Sağlık, Merve Baysal and Zafer Asım Kaplancıklı


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Synthesis, Biological Evaluation, Molecular Docking Study and Acute Oral Toxicity Study of Coupled Imidazole-Pyrimidine Derivatives


Shailee V. Tiwari, Anna Pratima G. Nikalje, Deepak K. Lokwani, Aniket P. Sarkate and Kizukala Jamir


View Abstract


Synthesis and Antioxidant Evaluation of a New Class of Thienopyrimidinerhodanine Hybrids


Kerru Nagaraju , Venkata H.S.S. Bhaskaruni, Ravada Kishore , Suresh Maddila, Parvesh Singh and Jonnalagadda B. Sreekantha


View Abstract


Anti-MRSA (Multidrug Resistant Staphylococcus aureus) Activity of 3-Substituted Coumarins


Uzma Salar, Khalid Mohammed Khan*, Humaira Muhammad, Muhammed Imran Fakhri, Sanaullah , Shahnaz Perveen and M. Iqbal Choudhary


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Nalidixic Acid Schiff Bases: Synthesis and Biological Evaluation


Asif Husain, Munendra Mohan Varshney, Versha Parcha, Aftab Ahmad and Shahalam Khan*


View Abstract


Exploration of Some Thiazolidine-2,4-dione and 2-Oxoindoline Derivatives Incorporating 3,4,5-Trimethoxybenzyl Moiety as Novel Anticancer Agents


Le Cong Huan, Hai Pham-The, Huong Le-Thi-Thu, Tran Phuong Thao , Do Nguyet Que , Nguyen-Thu Trang, Phan Thi Phuong Dung, Minji Pyo, Sang-Bae Han , Nguyen Thi Thuan and Nguyen-Hai Nam*


View Abstract


QSAR and Molecular Docking Studies on a Series of 1-Amino-5H-pyrido [4, 3-b]indol-4-carboxamides acting as Janus Kinase 2 (JAK2) Inhibitors


K. Anita, Tabassum Zafar, Satya P. Gupta and Bashirulla Shaik


View Abstract


The Effectiveness of Different Treatment Modalities for the Management of Ocular Injuries Following Sulfur Mustard Exposure


Yunes Panahi, Mostafa Naderi, Shahbaz Nekoozadeh, Seyyed Mahdi Rajaee and Amirhossein Sahebkar


View Abstract


Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents


Meda Haritha, Chekuri Sharmila Rani, Mandava V. Basaveswara Rao and Manojit Pal*


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High Throughput Screening and Molecular Docking of Calmodulin with Antagonists of Trifluoperazine and Phenothiazine Chemical Class


Abdelmonem Messaoudi*, Zarrin Basharat and Asif Naqvi


View Abstract


α-Glucosidase Inhibition, Antioxidant and Docking Studies of Hydroxycoumarins and their Mono and bis O-alkylated/acetylated Analogs


Parvesh Singh*, Nomandla Ngcoya, Ramgopal Mopuri, Nagaraju Kerru, Neha Manhas, Oluwakemi Ebenezer and Md. Shahidul Islam


View Abstract


Microwave-assisted Synthesis and Antifungal Activity of Novel 1,2,4- Triazole Thioether Derivatives Containing Pyrimidine Moiety


Meng Xu, Ya-Bo Zhu, Mei Wang, Ikhlas A. Khan, Xing-Hai Liu and Jian-Quan Weng*


View Abstract


Exploration of Angiotensin II Type 1 Receptor Modulators by Molecular Fingerprints and Docking Simulations


Sarfaraj Niazi*, Vishwamohana Hebbar M, Pooja Mathew, Raj Kumar D and Madhusudan Purohit


View Abstract


Synthesis and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines of thieno[2,3-d]pyrimidine Derivatives Containing Isoxazole Moiety


Jianping Yong*, Canzhong Lu and Xiaoyuan Wu


View Abstract


Synthesis of New Heteroaryl Substituted Morpholine Tagged Triazines and Evaluation of their Cytotoxic Activity


Siva Prasad Kasturi, Sujatha Surarapu, Srinivas Uppalanchi, Hasitha Shilpa Anantaraju, Shubham Dwivedi, Perumal Yogeeswari, Krishna S. Ethiraj and Jaya Shree Anireddy*


View Abstract


Synthesis and Assessment of Novel Anti-chlamydial Benzylidene Acylhydrazides Derivatives


Xiaofeng Bao, Ying Xue, Chao Xia, Yin Lu, Ningjing Yang and Yu Zhao*


View Abstract


Analytical Procedures for Secondary Metabolites Determination: Recent Trends and Future Perspectives


Gökhan Zengin, Luigi Menghini, Giuseppe Bellagamba, Marcelli Fabiana, Elisa De Luca, Luca Armellani, Roberta Cifelli, Arianna Granese, Nilgun Zengin and Abdurrahman Aktumsek


View Abstract


Design, Synthesis and Pharmacological Evaluation of Some Novel Tetrahydrocarbazoles as Potential COX-2 Inhibitors


Padmavathi Sakinala, Rupesh V Chikhale* and Madhuka Tajne


View Abstract


Design, Synthesis, and Screening of Hybrid Benzothiazolyl-Oxadiazoles as Anticonvulsant Agents


Sheikh Murtuja, M. Shaququzzaman and Mohammad Amir*


View Abstract


Herbal Medicines: Application of a Sequential Voltammetric Procedure to the Determination of Mercury, Copper, Lead, Cadmium and Zinc at Trace Level


Dora Melucci*, Marcello Locatelli, Francesco De Laurentiis, Gokhan Zengin and Clinio Locatelli


View Abstract


Synthesis and Herbicidal Evaluation of Aryloxyphenoxypropionate Derivatives Containing Purine Moiety


Jianjun Shi, Guihua Ren, Zhimeng Dai, Ningjie Wu, Jianquan Weng, Tianming Xu and Xing-Hai Liu*


View Abstract


Synthesis and Anti-influenza Activity of Novel Thiadiazole, Oxadiazole and Triazole Based Scaffolds


Samar S. Tawfik, Abdelbasset A. Farahat*, Magda A.-A El-Sayed, Atif S. Tantawy, Ola Bagato and Mohamed A. Ali


View Abstract


N-(2-(Arylmethylimino)Ethyl)-7-Chloroquinolin-4-Amine Derivatives: A New and Potent Class of Anticancer Agents


Ligia S. da Silveira Pinto, Marcus V. N. De Souza*, Carlos R. Kaiser, James L. Wardell and Solange M.S.V. Wardell


View Abstract


New Oxadiazole Derivatives: Synthesis and Appraisal of Their Potential as Antimicrobial Agents


Deboleena Dhara, Dhanya Sunil*, Pooja R. Kamath, K. Ananda, S. Shrilakshmi and S. Balaji


View Abstract


Inhibitory Effects of Flavonolignans from Silybum marianum (L.) Gaertn (Milk Thistle) on Function of Aldehyde Oxidase and Xanthine Oxidase in Rats


Nafiseh Alizadeh, Morteza Eskandani, Khalil Tondro, Mohamad-Reza Rashidi and Hossein Nazemiyeh*


View Abstract


Chemical Constituent and Biological Activities of Spatoglossum asperum J. Agardh from Oman Sea


Nasrin Movahhedin*, Hossein Nazemiyeh, Jaleh Barar, Solmaz Esnaashari and Amir Hossein Movahhedin


View Abstract


Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity


Adriano Mollica, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Pasqualina Punzi and Sako Mirzaie


View Abstract


Characterization and Evaluation of the Antioxidant Activity of Calamusenone, a Major Component of Hyptis pectinata (L.) Poit Essential Oil


Mairim R. Serafini*, Daviane M.C. Vergne, Paula P. Menezes, João P.A. Santos, Thallita K. Rabelo, Shanmugam Saravanan, Péricles B. Alves, Emmanoel V. Costa, Hugo César R. Jesus, Marcos J. Salvador, Daniel P. Gelain, José C.F. Moreira, Ricardo F. Rocha, Adriano A.S. Araújo and Lucindo J. Quintans-Júnior


View Abstract


Effect Antimicrobial, Gastroprotective and Healing of Hydroalcoholic Extract of Astronium fraxinifolium


Irwin Rose Aalencar de Menezes, Lucindo José Quintas-Júnior, Anita Oliveira Brito Pereira Bezerra Martins, Brito Pereira Bezerra Martins, Cícera Datiane de Morais Oliveira, Gerlânia Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Boligon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesário and Thales Sousa Coutinho


View Abstract


Gastroprotective Activity of Hydroalcoholic Extract of the Stryphnodendron Rotundifolium Mart. in Mice: Mechanism Actions Assay


Dayanne Rakelle de Oliveira, Lucindo José Quintas-Júnior, Thaís Rodrigues de Albuquerque, Francisco Elizaudo de Brito Júnior, Cícera Norma Fernandes, Heloísa Helena Fernandes de Souza, Aline Augusti Boligon, Margareth Linde Athayde, Cicero Bezerra Felipe, Henrique Douglas Melo Coutinho, Marta Regina Kerntopf, Roseli Barbosa and Irwin Rose Aalencar de Menezes


View Abstract


Effects of Asphodeline lutea Compounds on Toxicity Models in Isolated Rat Microsomes and Hepatocytes


Magdalena Kondeva-Burdina, Rumyana Simeonova, Vessela Vitcheva, Irina Lazarova*, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova, Gokhan Zengin and Nikolay D. Danchev


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In Vitro Evaluation of the Antibacterial Activity and Antibiotic- Modulatory Effect of Gracilaria cervicornis (Tuner) J. Agardh


Israeliane F. Cordeiro, Henrique D. M. Coutinho, João V. A. Ferreira, Lucindo José Quintans-Júnior*, Irwin R. A. Menezes, Micheline A. Lima, Thiago S. Freitas, Maria Isabeli P. Gonçalo, Francisco Licaon G. Rocha, Rívio Fabrício de Figueirêdo Furtado and Jacqueline C. Andrade


View Abstract


Solvent-free Mechano-chemical Synthesis of New Omeprazole Derived Metal Complexes: Characterization, Urease Inhibitory Kinetics and Selective Anti-Helicobacter pylori Activity


Muhammad Amin, Farooq Anwar, Mahmood Anwar, Abdul Karim, Khalid M. Alkharfy and Anwarul-Hassan Gilani*


View Abstract


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