Contents

Current Drug Targets - Immune, Endocrine & Metabolic Disorders, Volume 5 - Number 2

Editorial [(Guest Editors: Piero Portincasa and K.J. van Erpecum) Hot Topic: New Insights Into Bile Formation: from Secretion to Therapeutic ]

, 5(2): 129 - 130

Piero Portincasa and KJ van Erpecum


DOI: 10.2174/1568005310505020129




Lipid Transport into Bile and Role in Bile Formation

, 5(2): 131 - 135

Albert K. Groen and Ronald P.J. Oude Elferink


DOI: 10.2174/1568008054064887




Water Transport into Bile and Role in Bile Formation

, 5(2): 137 - 142

Giuseppe Calamita, Domenico Ferri, Patrizia Gena, Giuseppa E. Liquori, Raul A. Marinelli, Giuliano Meyer, Piero Portincasa and Maria Svelto


DOI: 10.2174/1568005310505020137




Ion Transport Across the Gallbladder Epithelium

, 5(2): 143 - 151

G. Meyer, F. Guizzardi, S. Rodighiero, R. Manfredi, S. Saino, C. Sironi, M. L. Garavaglia, C. Bazzini, G. Botta, P. Portincasa, G. Calamita and M. Paulmichl


DOI: 10.2174/1568008054064805




Contribution of Canalicular Glutathione Efflux to Bile Formation. From Cholestasis Associated Alterations to Pharmacological Intervention to Modify Bile Flow

, 5(2): 153 - 161

Ignazio Grattagliano, Piero Portincasa, Vincenzo O. Palmieri and Giuseppe Palasciano


DOI: 10.2174/1568005310505020153




The Genetic Background of Cholesterol Gallstone Formation: An Inventory of Human Lithogenic Genes

, 5(2): 163 - 170

Frank Lammert and Siegfried Matern


DOI: 10.2174/1568005310505020163




Effects of Fatty Acid Bile Acid Conjugates (FABACs) on Biliary Lithogenesis: Potential Consequences for Non-Surgical Treatment of Gallstones

, 5(2): 171 - 175

Fred M. Konikoff and Tuvia Gilat


DOI: 10.2174/1568008054064904




Modulation of Cholesterol Crystallization in Bile. Implications for Non- Surgical Treatment of Cholesterol Gallstone Disease

, 5(2): 177 - 184

Piero Portincasa, Antonio Moschetta, Karel J. van Erpecum, Michele Vacca, Michele Petruzzelli, Giuseppe Calamita, Giuliano Meyer and Giuseppe Palasciano


DOI: 10.2174/1568005310505020177




Drugs Affecting Biliary Lipid Secretion and Gallbladder Motility: Their Potential Role in Gallstone Treatment and Prevention

, 5(2): 185 - 191

Gerard P. vanBerge-Henegouwen, Niels G. Venneman, Karel J. van Erpecum and Piero Portincasa


DOI: 10.2174/1568005310505020185




Pharmacological Manipulation of Biliary Water and Lipids: Potential Consequences for Prevention of Acute Biliary Pancreatitis

, 5(2): 193 - 198

Niels G. Venneman, Gerard P. vanBerge-Henegouwen and Karel J. van Erpecum


DOI: 10.2174/1568008054064814




Manipulation of Biliary Lipids by Gene Therapy: Potential Consequences for Patients with Progressive Familial Intrahepatic Cholestasis

, 5(2): 199 - 202

Ronald P.J. Oude Elferink


DOI: 10.2174/1568005310505020199




Effects of Leptin on Biliary Lipids: Potential Consequences for Gallstone Formation and Therapy in Obesity

, 5(2): 203 - 208

Nahum Mendez-Sanchez, Guadalope Ponciano-Rodrigoez, Norberto Chavez-Tapia and Misael Uribe


DOI: 10.2174/1568005310505020203




Assessment of Modes of Action and Efficacy of Plasma Cholesterol- Lowering Drugs: Measurement of Cholesterol Absorption, Cholesterol Synthesis and Bile Acid Synthesis and Turnover Using Novel Stable Isotope Techniques

, 5(2): 209 - 218

Frans Stellaard and Folkert Kuipers


DOI: 10.2174/1568005310505020209




Myocardial Insulin Resistance and Cardiac Complications of Diabetes

, 5(2): 219 - 226

E. Dale Abel


DOI: 10.2174/1568005310505020219




Therapeutic Targets for the Prevention of Type 1 Diabetes Mellitus

, 5(2): 227 - 236

N. Singh and J. P. Palmer


DOI: 10.2174/1568005310505020227




The Mammalian Innate Immune System: Potential Targets for Drug Development

, 5(2): 237 - 247

Thomas T. Wheeler and Kylie A. Hood


DOI: 10.2174/1568005310505020237




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