Contents

Drug Metabolism Letters, Volume 6 - Number 4

Formation/Fate of Reactive Metabolites from General Anesthetics and A Comparison of Toxic and Non-Toxic Analogues: A DFT Study

, 6(4): 221 - 234

Sonam Bhatia, Vaibhav A. Dixit, Harish Jangra and Prasad V. Bharatam


DOI: 10.2174/1872312811206040001




Pharmacokinetic Profile of A New Diclofenac Prodrug without Gastroulcerogenic Effect

, 6(4): 235 - 241

Michel Leandro de Campos, Helen Mariana Baldan-Cimatti, Marcelo Gomes Davanco, Marco Antonio Ferraz Nogueira, Elias Carvalho Padilha, Caroline Damico Candido, Jean Leandro dos Santos and Rosangela Goncalves Peccinini


DOI: 10.2174/1872312811206040002




Renal and Hepatic Kinetics of Tc-99m-labelled Hexakis-methoxy-isobutyl Isonitrile

, 6(4): 242 - 246

Sabina Dizdarevic, Mark Aplin, Nicola Ryan, Stephen G. Holt, Lawrence Goldberg, Kenneth A. Miles and A. Michael Peters


DOI: 10.2174/1872312811206040003




The Evaluation of CYP2B6 Inhibition by Artemisinin Antimalarials in Recombinant Enzymes and Human Liver Microsomes

, 6(4): 247 - 257

Therese Ericsson, Collen Masimirembwa, Angela Abelo and Michael Ashton


DOI: 10.2174/1872312811206040004




Opposing – Activating or Inhibitory – Effects of Cimetidine and Daidzein on Human ADH1C Activity Depending on Substrates and Solvents

, 6(4): 258 - 264

Ronny Kollock and Hansruedi Glatt


DOI: 10.2174/1872312811206040005




Application of 1D and 2D 1H-NMR in the Structural Elucidation of a N-Glucuronidated Metabolite and Oxidized Metabolites Generated in Microsomal Incubation

, 6(4): 265 - 274

Julius L. Apuy, April Bai, David Paisner, Sayee G. Hegde and Mehran F. Moghaddam


DOI: 10.2174/1872312811206040006




Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2

, 6(4): 275 - 284

Jayalakshmi Sridhar, Jamie Ellis, Patrick Dupart, Jiawang Liu, Cheryl L. Stevens and Maryam Foroozesh


DOI: 10.2174/1872312811206040007




A Transcellular Assay to Assess the P-gp Inhibition in Early Stage of Drug Development

, 6(4): 285 - 291

Jan-Shiang Taur, Edgar L. Schuck and Nancy Y. Wong


DOI: 10.2174/1872312811206040008




Acknowledgement to the Reviewers:

, 6(4): 292


DOI: 10.2174/1872312811206040009




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