Contents

Drug Metabolism Letters, Volume 4 - Number 4

A Multi-Endpoint Evaluation of Cytochrome P450 1A2, 2B6 and 3A4 Induction Response in Human Hepatocyte Cultures After Treatment with β - Naphthoflavone, Phenobarbital and Rifampicin

, 4(4): 185 - 194

J. G. Zhang, Thuy Ho, Alanna L. Callendrello, Charles L. Crespi and David M. Stresser


DOI: 10.2174/187231210792928224




P-Glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice

, 4(4): 195 - 201

Michael Tagen, Yanli Zhuang, Fan Zhang, K. Elaine Harstead, Jun Shen, Paula Schaiquevich, Charles H. Fraga, John C. Panetta, Christopher M. Waters and Clinton F. Stewart


DOI: 10.2174/187231210792928251




P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

, 4(4): 202 - 212

Johnny J. Yang, Mark N. Milton, Shaoxia Yu, Mingxiang Liao, Ning Liu, Jing-Tao Wu, Liang-Shang Gan, Suresh K. Balani, Frank W. Lee, Shimoga Prakash and Cindy Q. Xia


DOI: 10.2174/187231210792928279




Contribution of Three CYP3A Isoforms to Metabolism of R- and S-Warfarin

, 4(4): 213 - 219

Drew R. Jones, So-Young Kim, Gunnar Boysen, Chul-Ho Yun and Grover P. Miller


DOI: 10.2174/187231210792928242




Reversible Covalent Binding of Neratinib to Human Serum Albumin In Vitro

, 4(4): 220 - 227

Appavu Chandrasekaran, Li Shen, Susan Lockhead, Aram Oganesian, Jianyao Wang and JoAnn Scatina


DOI: 10.2174/187231210792928206




Daunorubicin Metabolism in Leukemic Cells Isolated from Patients with Acute Myeloid Leukemia

, 4(4): 228 - 232

Alex Bogason, Michele Masquelier, Pierre Lafolie, Cristine Skogastierna, Christer Paul, Astrid Gruber and Sigurd Vitols


DOI: 10.2174/187231210792928260




In Vitro Screening of Metabolic Clearance Using Two Concentration Points

, 4(4): 233 - 240

Eric T. Williams, Nadia Farah, Robert D. Pelletier and W. George Lai


DOI: 10.2174/187231210792928288




Comparative Efflux of Saquinavir, Ritonavir and Lopinavir from Primary Human Cells

, 4(4): 241 - 245

Bilge Diker, Omar Janneh, Rolf P.G. van Heeswijk and Karen F.T. Copeland


DOI: 10.2174/187231210792928297




Co-Expression of Recombinant Human CYP2C9 with Human Cytochrome P450 Reductase in Protease Deficient S. cerevisiae Strain at a Higher Scale Yields an Enzyme of Higher Specific Activity

, 4(4): 246 - 253

K. N. Purnachandra Rao, Sunil Kumar Suman, Y. Ravi Kiran, Arup Ranjan Kuanr, Anuj Kumar Gupta, Kunal Bhalla, Vipul Kumar, Prabuddha Kundu, Kajal Arora and Rajeev Soni


DOI: 10.2174/187231210792928233




Two Branched Polar Groups and Polar Linker Moieties of Thiophene Amide Derivatives Are Essential for MRP2/ABCC2 Recognition

, 4(4): 254 - 261

Yiding Hu, Kathleen E. Sampson, Li Xing, Na Li, Bruce R. Heyde, Jin Xie and Yurong Lai


DOI: 10.2174/187231210792928215




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