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Contents

Drug Metabolism Letters, Volume 4 - Number 4


P-Glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice

, 4(4): 195 - 201

Michael Tagen, Yanli Zhuang, Fan Zhang, K. Elaine Harstead, Jun Shen, Paula Schaiquevich, Charles H. Fraga, John C. Panetta, Christopher M. Waters and Clinton F. Stewart


DOI: 10.2174/187231210792928251


P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

, 4(4): 202 - 212

Johnny J. Yang, Mark N. Milton, Shaoxia Yu, Mingxiang Liao, Ning Liu, Jing-Tao Wu, Liang-Shang Gan, Suresh K. Balani, Frank W. Lee, Shimoga Prakash and Cindy Q. Xia


DOI: 10.2174/187231210792928279



Reversible Covalent Binding of Neratinib to Human Serum Albumin In Vitro

, 4(4): 220 - 227

Appavu Chandrasekaran, Li Shen, Susan Lockhead, Aram Oganesian, Jianyao Wang and JoAnn Scatina


DOI: 10.2174/187231210792928206


Daunorubicin Metabolism in Leukemic Cells Isolated from Patients with Acute Myeloid Leukemia

, 4(4): 228 - 232

Alex Bogason, Michele Masquelier, Pierre Lafolie, Cristine Skogastierna, Christer Paul, Astrid Gruber and Sigurd Vitols


DOI: 10.2174/187231210792928260




Co-Expression of Recombinant Human CYP2C9 with Human Cytochrome P450 Reductase in Protease Deficient S. cerevisiae Strain at a Higher Scale Yields an Enzyme of Higher Specific Activity

, 4(4): 246 - 253

K. N. Purnachandra Rao, Sunil Kumar Suman, Y. Ravi Kiran, Arup Ranjan Kuanr, Anuj Kumar Gupta, Kunal Bhalla, Vipul Kumar, Prabuddha Kundu, Kajal Arora and Rajeev Soni


DOI: 10.2174/187231210792928233




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