Drug Metabolism Letters, Volume 4 - Number 2

Pharmacokinetics of Pseudoephedrine in Rats, Dogs, Monkeys and Its Pharmacokinetic-Pharmacodynamic Relationship in a Feline Model of Nasal Congestion

, 4(2): 56 - 61

Jairam R. Palamanda, Hong Mei, Richard Morrison, Robbie L. McLeod, Kevin McCormick, Michel Corboz, Xiaoying Xu, Walter Korfmacher, Lisa Broske and Amin A. Nomeir

DOI: 10.2174/187231210791292762

Sulfation of Drug Compounds by the Zebrafish Cytosolic Sulfotransferases (SULTs)

, 4(2): 62 - 68

Katsuhisa Kurogi, Jeremiah Dillon, Ahmed Nasser, Ming-Yih Liu, Frederick E. Williams, Yoichi Sakakibara, Masahito Suiko and Ming-Cheh Liu

DOI: 10.2174/187231210791292690

Assessment of Competitive and Mechanism-Based Inhibition by Clarithromycin: Use of Domperidone as a CYP3A Probe-Drug Substrate and Various Enzymatic Sources Including a New Cell-Based Assay with Freshly Isolated Human Hepatocytes

, 4(2): 69 - 76

Veronique Michaud and Jacques Turgeon

DOI: 10.2174/187231210791292717

Application of Modern Drug Metabolism Structure Determination Tools and Assays to the In Vitro Metabolism of Imiloxan

, 4(2): 77 - 87

William L. Fitch, Yuan Chen, Liling Liu, Axel Paehler and May Young

DOI: 10.2174/187231210791292753

Ligand-Dependent Assembly of Pregnane X Receptor, Constitutive Androstane Receptor and Liver X Receptor Is Applicable to Identify Ligands

, 4(2): 88 - 94

Kaoru Kobayashi, Kosuke Saito, Sachiko Takagi and Kan Chiba

DOI: 10.2174/187231210791292744

Characterization of CYP3A Isozymes Involved in the Metabolism of Domperidone: Role of Cytochrome b5 and Inhibition by Ketoconazole

, 4(2): 95 - 103

Veronique Michaud, Chantale Simard and Jacques Turgeon

DOI: 10.2174/187231210791292735

Identifying a Higher Throughput Assay for Metabolism Dependent Inhibition (MDI)

, 4(2): 104 - 113

Mahmud Kajbaf, Emiliano Palmieri, Raffaele Longhi and Stefano Fontana

DOI: 10.2174/187231210791292708

siRNA-Mediated Knock-Down of P-Glycoprotein Expression Reveals Distinct Cellular Disposition of Anticancer Tyrosine Kinases Inhibitors

, 4(2): 114 - 119

Amina Haouala, Holger Rumpold, Gerold Untergasser, Thierry Buclin, Hans-Beat Ris, Nicolas Widmer and Laurent A. Decosterd

DOI: 10.2174/187231210791292726

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