Contents

Drug Metabolism Letters, Volume 10 - Number 3


Research Article

New Screening Criteria Setting on Evaluation of Cytochrome P450 Induction Using HepaRG Cells with Multiplex Branched DNA Technologies in Early Drug Discovery

, 10(3): 152 - 160

Akira Ogasawara, Nao Torimoto, Naoki Tsuda, Fumika Aohara, Rikiya Ohashi, Yasuhiro Yamada and Hideki Taniguchi


DOI: 10.2174/1872312810666160822110011



Research Article

Intracellular Retention of Three Quinuclidine Derivatives in Caco-2 Permeation Experiments: Mechanisms and Impact on Estimating Permeability and Active Efflux Ratio

, 10(3): 161 - 171

Hong Jin, Sudarshan Kapadnis, Ting Chen, Dooyoung Lee, Andrew McRiner, Andrew Cook, Duane A. Burnett, Gerhard Koenig and Cuyue Tang


DOI: 10.2174/1872312810666160725123322



Research Article

Application of a “Fit for Purpose” PBPK Model to Investigate the CYP3A4 Induction Potential of Enzalutamide

, 10(3): 172 - 179

Rangaraj Narayanan, Matthew Hoffmann, Gondi Kumar and Sekhar Surapaneni


DOI: 10.2174/1872312810666160729124745



Research Article

An Investigation of Sodium Fusidate and Recombinant Cytochrome P450 Enzymes Inhibition In-Vitro

, 10(3): 180 - 186

John Mishriky, Jacqueline Balassone, Zenah Bashour, Simranjit Kaur, Vini Raman, Robel Getachew, Narin Osman, Daniel Guidone, Vincent Chan and Peter J. Little


DOI: 10.2174/1872312810666160607015045



Research Article

Inhibition of Procarcinogen Activating Enzyme CYP1A2 Activity and Free Radical Formation by Caffeic Acid and its Amide Analogues

, 10(3): 187 - 194

Paitoon Narongchai, Kanokporn Niwatananun, Siripun Narongchai, Winthana Kusirisin and Churdsak Jaikang


DOI: 10.2174/1872312810666160608123113



Research Article

The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes

, 10(3): 195 - 199

Hong Liu, Rangaraj Narayanan, Matthew Hoffmann and Sekhar Surapaneni


DOI: 10.2174/1872312810666160719143703



Research Article

Identification and Characterization of the Human Cytosolic Sulfotransferases Mediating the Sulfation of Clioquinol and Iodoquinol

, 10(3): 200 - 205

Akihiro Yamamoto, Maame Debrah-Pinamang, Nicholas J. DiModica, Katsuhisa Kurogi, Ali A. Naqvi, Ying Hui, Yoichi Sakakibara, Masahito Suiko and Ming-Cheh Liu


DOI: 10.2174/1872312810666160719142850



Research Article

UHPLC Quantitation Method for New Thiazolidinedione LPSF/GQ-02 and In Vitro/In Vivo Kinetic Studies

, 10(3): 206 - 212

Carla Monalizi Vieira, Michel Leandro de Campos, Elias Carvalho Padilha, Marina Pitta, Ivan da Rocha Pitta, Maria do Carmo Alves de Lima and Rosângela Gonçalves Peccinini


DOI: 10.2174/1872312810666160725124554



Research Article

CYP2B6 and OPRM1 Receptor Polymorphisms at Methadone Clinics And Novel OPRM1 Haplotypes: A Cross-Sectional Study

, 10(3): 213 - 218

Ahmad Abdulrahman AlMeman, Rusli Ismail and Markus Perola


DOI: 10.2174/1872312810666160810104040



Research Article

Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-‘Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo

, 10(3): 219 - 226

Pollen K. Yeung, Shyam S. Kolathuru and Remigius U. Agu


DOI: 10.2174/1872312810666160607013859




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