Contents

Drug Metabolism Letters, Volume 10 - Number 2

Meet Our Editorial Board Member

, 10(2): 71

Mert Ulgen


DOI: 10.2174/187231281002160614161435




Commentary: A Myriad Aberrations on Information of Ontogeny of Drug Metabolizing Enzymes in the Pediatric Population: An Obstacle for Personalizing Drug Therapy in the Pediatric Population

, 10(2): 72 - 74

Chakradhara Rao S. Uppugunduri and Marc Ansari


DOI: 10.2174/1872312810666160224143443




The Effects of Statin Therapy on the Human Airway

, 10(2): 75 - 82

Lorraine Thong, John MacSharry and Desmond M. Murphy


DOI: 10.2174/1872312810666160303112012





Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 10(2): 83 - 90

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836





Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

, 10(2): 91 - 100

Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright


DOI: 10.2174/1872312810666160411144358





In Vitro Study of UGT Metabolism and Permeability of Orientin and Isoorientin, Two Active flavonoid C-glycosides

, 10(2): 101 - 110

Jian Shi, Lijun Zhu, Ye Li, Haihui Zheng, Jia Yu, Linlin Lu and Zhongqiu Liu


DOI: 10.2174/1872312810666160219121217





Biotransformation of Cobicistat: Metabolic Pathways and Enzymes

, 10(2): 111 - 123

Pengcheng Wang, Amina I. Shehu, Ke Liu, Jie Lu and Xiaochao Ma


DOI: 10.2174/1872312810666160303112212





In Vitro CYP2D Inhibitory Effect and Influence on Pharmacokinetics and Pharmacodynamic Parameters of Metoprolol Succinate by Terminalia arjuna in Rats

, 10(2): 124 - 135

Alice Varghese, Jay Savai, Shruti Mistry, Preeti Khandare, Kalyani Barve, Nancy Pandita and Ram Gaud


DOI: 10.2174/1872312810666160219121415





Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

, 10(2): 136 - 143

Hoa Le, Peter W. Fan, Susan Wong, Shuguang Ma, James P. Driscoll, Cornelis E.C.A. Hop and S. Cyrus Khojasteh


DOI: 10.2174/1872312810666160427104954





Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

, 10(2): 144 - 150

Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160511150558





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