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Contents

Drug Metabolism Letters, Volume 1 - Number 2

Peroxynitrite Induces Apoptosis and Decline in Intracellular Free Mg with Concomitant Elevation in [Ca2+]i in Rat Aortic Smooth Muscle Cells:Possible Roles of Extracellular and Intracellular Magnesium Ions in Peroxynitrite-Induced Cell Death

, 1(2): 85 - 89

Jianfeng Li, Wenyan Li, Weimin Liu, Bella T. Altura and Burton M. Altura


DOI: 10.2174/187231207780363651




An Estimate of the Number of Hepatocyte Donors Required to Provide Reasonable Estimates of Human Hepatic Clearance from In Vitro Experiments

, 1(2): 91 - 95

James Byers, Kenneth Bachmann, Heather Eng, Anand Katta, Donald White, Ritwik Ghosh, Nicola J. Hewitt, Paul Silber and Genfu Chen


DOI: 10.2174/187231207780363660




Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine

, 1(2): 97 - 100

K. A. Rittenbach and G. B. Baker


DOI: 10.2174/187231207780363589




A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans

, 1(2): 101 - 107

F. Desmoulin, C. Claparols, D. Bon, G. Larrieu, R. Martino and M. Malet-Martino


DOI: 10.2174/187231207780363615




Assessment of Cryopreserved Hepatocytes as an Alternative to Fresh Hepatocytes forComparative InterspeciesMetabolism Studieswith Suitable Acceptance Criteria

, 1(2): 109 - 120

Ziqiang (Zack) Cheng, Christine E. Herron, Gary Bowers and Mark de Serres


DOI: 10.2174/187231207780363624




The Human Sperm Glutathione System: A Key Role in Male Fertility and Successful Cryopreservation

, 1(2): 121 - 126

Marcos Meseguer, Jose Antonio Martinez-Conejero, Lourdes Muriel, Antonio Pellicer, Jose Remohi and Nicolas Garrido


DOI: 10.2174/187231207780363633




Application of Simple Mathematical Expressions to Relate Half-Lives of Drugs in Mice to Those in Humans

, 1(2): 127 - 129

Kenneth Bachmann, Jonathan Chupka, Paul Erhardt and Donald White


DOI: 10.2174/187231207780363606




Intracellular Delivery of Nanogel-Quantum Dot Hybrid Nanoparticles into Human Periodontal Ligament Cells

, 1(2): 131 - 135

Tomoe Fukui, Hiroaki Kobayashi, Urara Hasegawa, Toshiyuki Nagasawa, Kazunari Akiyoshi and Isao Ishikawa


DOI: 10.2174/187231207780363570




Brief Review of Polymorphic Drug-Metabolizing Enzymes in Japanese Populations: Development of a Higher-Throughput Genotyping Method and Proposed Applications

, 1(2): 137 - 142

Takahiro Kubota


DOI: 10.2174/187231207780363679




Resin-Salve from Norway Spruce - A Potential Method to Treat Infected Chronic Skin Ulcers?

, 1(2): 143 - 145

Arno Sipponen, Merja Rautio, Janne J. Jokinen, Tapio Laakso, Pekka Saranpaa and Jouni Lohi


DOI: 10.2174/187231207780363598




The Utility of Stable Cell Lines to Assess Species Differences in PXR Transactivation

, 1(2): 147 - 152

Michael W. Sinz, Devin Pray and Judy Raucy


DOI: 10.2174/187231207780363561




Disposition of Vorinostat, A Novel Histone Deacetylase Inhibitor and Anticancer Agent, in Preclinical Species

, 1(2): 153 - 161

Punam Sandhu, Paul A. Andrews, Maribeth P. Baker, Kenneth A. Koeplinger, Eric D. Soli, Thomas Miller and Thomas A. Baillie


DOI: 10.2174/187231207780363642




Frequency of CYP1A2 Polymorphism in Beagle Dogs

, 1(2): 163 - 165

Valerie J. Whiterock, Terrye A. Delmonte, Lester E. Hui, Tami L. Orcutt and Michael W. Sinz


DOI: 10.2174/187231207780363688




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