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Open Access Articles


The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells

, 2016; 10(4): 295 - 305

Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama




Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

, 2016; 10(2): 91 - 100

Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright




Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83 - 90

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam





Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

, 2016; 10(2): 144 - 150

Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam





Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers

, 2008; 2(2): 76 - 82

Nicolas Ansermot, Michela Rebsamen, Jocelyne Chabert, Marc Fathi, Marianne Gex-Fabry, Youssef Daali, Marie Besson, Michel Rossier, Serge Rudaz, Denis Hochstrasser, Pierre Dayer and Jules Desmeules






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