Bentham Science Logo

Open Access Articles

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 2019; 13: 1 - 8 (E-Pub Ahead of Print)

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Yu. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan




Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13: 1 - 12 (E-Pub Ahead of Print)

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*





Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification

, 2018; 12(2): 93 - 100

William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson





Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy

, 2018; 12(2): 145 - 152

Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*





A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes)

, 2018; 12(2): 132 - 137

Albert P. Li*, Kirsten Amaral and Ming-Chih D. Ho





In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone

, 2018; 12(2): 101 - 116

Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*





In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS

, 2018; 12(1): 33 - 53

Wan-Yong Feng*, Jenny Wen and Kathe Stauber





Comparison of Rat and Human Pulmonary Metabolism Using Precisioncut Lung Slices (PCLS)

, 2018; 12: 1 - 11 (E-Pub Ahead of Print)

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krahenbuhl and Gian Camenisch





Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies

, 2018; 12: 1 - 16 (E-Pub Ahead of Print)

Poonam Giri, Harilal Patel and Nuggehally R Srinivas*





The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells

, 2016; 10(4): 295 - 305

Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama




Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

, 2016; 10(2): 91 - 100

Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright




Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83 - 90

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam





Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

, 2016; 10(2): 144 - 150

Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam





Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers

, 2008; 2(2): 76 - 82

Nicolas Ansermot, Michela Rebsamen, Jocelyne Chabert, Marc Fathi, Marianne Gex-Fabry, Youssef Daali, Marie Besson, Michel Rossier, Serge Rudaz, Denis Hochstrasser, Pierre Dayer and Jules Desmeules






Webmaster Contact: info@benthamscience.net
Copyright © 2019 Bentham Science