Most Cited Articles


Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

, 2015; 9(2): 119-131.

Ben-Quan Shen, Daniela Bumbaca, Qin Yue, Ola Saad, Jay Tibbitts, S. Cyrus Khojasteh and Sandhya Girish


DOI: 10.2174/1872312809666150602151922



Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays

, 2015; 9(1): 3-7.

Norie Murayama, Takashi Usui, Nicky Slawny, Christophe Chesne and Hiroshi Yamazaki


DOI: 10.2174/1872312809666150119104806



Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836



Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents

, 2016; 10(4): 244-253.

Shotaro Uehara, Yasuhiro Uno, Takako Suzuki, Takashi Inoue, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki*


DOI: 10.2174/1872312810666161114144412


Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

, 2016; 10(2): 136-143.

Hoa Le, Peter W. Fan, Susan Wong, Shuguang Ma, James P. Driscoll, Cornelis E.C.A. Hop and S. Cyrus Khojasteh


DOI: 10.2174/1872312810666160427104954


Gender Difference of Hepatic and Intestinal CYP3A4 in CYP3AHumanized Mice Generated by a Human Chromosome-engineering Technique

, 2017; 11(1): 60-67.

Kaoru Kobayashi*, Chihiro Abe, Mika Endo, Yasuhiro Kazuki, Mitsuo Oshimura and Kan Chiba


DOI: 10.2174/1872312811666170404153804



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