Drug Metabolism Letters
Volume 15, 3 Issues, 2021
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access
In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research
Most Cited Articles
Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions
, 2016; 10(1): 38-48.Florence Namour*, Julie Desrivot, Annegret Van der Aa, Pille Harrison, Chantal Tasset and Gerben van`t Klooster
DOI: 10.2174/1872312810666151223103353
Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions
, 2018; 12(1): 3-13.Susan Wong, Utkarsh Doshi, Peter Vuong, Ning Liu, Suzanne Tay, Hoa Le, Mika Kosaka, Jane R. Kenny, Albert P. Li and Zhengyin Yan*
DOI: 10.2174/1872312812666171213114422
Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats
, 2015; 9(2): 119-131.Ben-Quan Shen, Daniela Bumbaca, Qin Yue, Ola Saad, Jay Tibbitts, S. Cyrus Khojasteh and Sandhya Girish
DOI: 10.2174/1872312809666150602151922
Ontogeny of Human Conjugating Enzymes
, 2015; 9(2): 99-108.Michael W.H. Coughtrie
DOI: 10.2174/1872312809666150602151213
Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays
, 2015; 9(1): 3-7.Norie Murayama, Takashi Usui, Nicky Slawny, Christophe Chesne and Hiroshi Yamazaki
DOI: 10.2174/1872312809666150119104806
In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities
, 2015; 9(1): 48-62.Charles Awortwe, Vamshi K. Manda, Cristina Avonto, Shabana I. Khan, Ikhlas A. Khan, Larry A. Walker, Patrick J. Bouic and Bernd Rosenkranz
DOI: 10.2174/1872312809666150119110200
Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability
, 2016; 10(2): 83-90.Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam
DOI: 10.2174/1872312810666160223121836
New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation
, 2018; 12(2): 84-92.Mithat Gunduz*, Upendra A. Argikar, Amanda L. Cirello and Jennifer L. Dumouchel
DOI: 10.2174/1872312812666180611113656
Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues
, 2018; 12(1): 24-32.Khondoker Alam, Taleah Farasyn, Kai Ding and Wei Yue*
DOI: 10.2174/1872312812666180326110146
Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line
, 2018; 12(2): 138-144.Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani
DOI: 10.2174/1872312812666180709150440
Downregulation of Hepatic Carbonyl Reductase Type 1 in End-Stage Renal Disease
, 2015; 9(2): 111-118.Osama Y. Alshogran, Bradley L. Urquhart and Thomas D. Nolin
DOI: 10.2174/1872312809666150818111626
Evaluation of Herb-Drug Interaction of Synacinn™ and Individual Biomarker through Cytochrome 450 Inhibition Assay
, 2018; 12(1): 62-67.Nur Syukriah Ab Rahman, Fadzilah Adibah Abd Majid*, Mohd Effendy Abd Wahid, Ain Nabihah Zainudin, Siti Nurazwa Zainol, Hassan Fahmi Ismail, Tet Soon Wong, Nirbhay Kumar Tiwari, Sanjeev Giri and Vijaya Bhargava
DOI: 10.2174/1872312812666180314112457
Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy
, 2018; 12(2): 145-152.Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*
DOI: 10.2174/1872312812666180625122810
Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification
, 2018; 12(2): 93-100.William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson
DOI: 10.2174/1872312812666180802093347
Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents
, 2016; 10(4): 244-253.Shotaro Uehara, Yasuhiro Uno, Takako Suzuki, Takashi Inoue, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki*
DOI: 10.2174/1872312810666161114144412
A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes)
, 2018; 12(2): 132-137.Albert P. Li*, Kirsten Amaral and Ming-Chih D. Ho
DOI: 10.2174/1872312812666180820142141
Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study
, 2019; 13(1): 64-76.Muthusamy Ramesh* and Prasad V. Bharatam
DOI: 10.2174/1872312812666180913120736
Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)
, 2019; 13(1): 53-63.Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch
DOI: 10.2174/1872312812666181022114622
Elucidating the Mechanism of Tofacitinib Oxidative Decyanation
, 2016; 10(2): 136-143.Hoa Le, Peter W. Fan, Susan Wong, Shuguang Ma, James P. Driscoll, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
DOI: 10.2174/1872312810666160427104954
Gender Difference of Hepatic and Intestinal CYP3A4 in CYP3AHumanized Mice Generated by a Human Chromosome-engineering Technique
, 2017; 11(1): 60-67.Kaoru Kobayashi*, Chihiro Abe, Mika Endo, Yasuhiro Kazuki, Mitsuo Oshimura and Kan Chiba
DOI: 10.2174/1872312811666170404153804
Effect of CYP2D6 Poor Metabolizer Phenotype on Stereoselective Nebivolol Pharmacokinetics
, 2018; 12(1): 68-70.Carolina P. Vieira, Daniel V. Neves, Eduardo B. Coelho and Vera Lucia Lanchote*
DOI: 10.2174/1872312812666180420104945
In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone
, 2018; 12(2): 101-116.Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*
DOI: 10.2174/1872312812666180816164626
Effect of Aqueous Extract of Azadirachta indica Leaves on Pharmacokineics and Pharmacodynamics of Glipizide
, 2019; 13(1): 19-24.Sugandha Chaudhari*, Shitalkumar Zambad and Mohammed Ali
DOI: 10.2174/1872312812666181106115247
Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies
, 2019; 13(1): 3-18.Poonam Giri, Harilal Patel and Nuggehally R. Srinivas*
DOI: 10.2174/1872312812666181119154734
LC-MS/MS Identification and Structural Characterization of Main Biodegradation Products of Nitroproston - A Novel Prostaglandin-based Pharmaceutical Compound
, 2018; 12(1): 54-61.Natalia V. Mesonzhnik*, Natalia E. Moskaleva, Ksenia M. Shestakova, Ksenya O. Kurynina, Pavel A. Baranov, Natalia M. Gretskaya, Igor V. Serkov, Igor I. Lyubimov, Vladimir V. Bezuglov and Svetlana A. Appolonova
DOI: 10.2174/1872312812666180309160927
Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH
, 2019; 13(2): 102-110.Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*
DOI: 10.2174/1872312813666190207150207
Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines
, 2019; 13(1): 25-36.Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*
DOI: 10.2174/1872312813666181129101507
Effects of Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) Exposures on Brain Alcohol Metabolizing Enzyme Activities
, 2018; 12(2): 117-124.Emine B. Yalcin, Ming Tong, Gina Gallucci and Suzanne M. de la Monte*
DOI: 10.2174/1872312812666180611115418
In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS
, 2018; 12(1): 33-53.Wan-Yong Feng*, Jenny Wen and Kathe Stauber
DOI: 10.2174/1872312812666180418142056
Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells
, 2018; 12(1): 14-23.Akira Ogasawara*, Nozomu Kato, Nao Torimoto, Fumika Aohara, Rikiya Ohashi, Yasuhiro Yamada and Hideki Taniguchi
DOI: 10.2174/1872312812666180119114013
Editor-in-Chief
Zhiyang Zhao
Alliance Pharma
Malvern, PA
(USA)
Biography
Alliance Pharma
Malvern, PA
Biography
Biography of Zhiyang Zhao
Zhiyang Zhao received his Ph.D. degree in Medicinal Chemistry from Virginia Tech, Blacksburg, Virginia, USA. Dr. Zhao’s biopharmaceutical/pharmaceutical work experience encompasses over 25 years of research in metabolic and pharmacokinetic properties of compounds for drug discovery and development at Pfizer, GlaxoSmithKline and Amgen. Currently, Dr. Zhao serve as Chief Scientific Officer (CSO) at Alliance Pharma, Inc. and appointed as an adjunct professor at the School of Pharmacy, the University of North Carolina at Chapel Hill. Dr. Zhao has published over 50 peer reviewed original research papers and patents in the areas of new drug targets, drug metabolism, pharmacokinetics, and toxicology.
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Journal History
Drug Metabolism Letters was launched in 2007. Dr. Zhiyang Zhao serves as the Editor-in-Chief of the journal.
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