Most Accessed Articles

Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)

, 2017; 11(1): 21-28.

Ryan H. Takahashi, Cyrus Khojasteh, Matthew Wright, Cornelis E.C.A. Hop and Shuguang Ma*


DOI: 10.2174/1872312811666170710193229


The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters

, 2017; 11(2): 111-118.

Jonathan Cheong, Jason S. Halladay, Emile Plise, Jasleen K. Sodhi and Laurent Salphati*


DOI: 10.2174/1872312811666171010101248


A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays

, 2016; 10(4): 264-269.

Siva P. Putluru*, Murali K. Matta, Deepak Ahire, Murali Subramanian, Michael Sinz and Sandhya Mandlekar


DOI: 10.2174/1872312810666161124143522


Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4] triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy: Evidence of Glyoxal Intermediate Involvement

, 2017; 11(2): 144-148.

Mithat Gunduz*, Amanda L. Cirello, Peter Klimko, Jennifer L. Dumouchel and Upendra A. Argikar


DOI: 10.2174/1872312811666171106151730


Transactivation Assays that Identify Indirect and Direct Activators of Human Pregnane X Receptor (PXR, NR1I2) and Constitutive Androstane Receptor (CAR, NR1I3)

, 2017; 11(2): 128-137.

Marija Pinne*, Elsa Ponce and Judy L. Raucy


DOI: 10.2174/1872312812666171207113639


Application of a “Fit for Purpose” PBPK Model to Investigate the CYP3A4 Induction Potential of Enzalutamide

, 2016; 10(3): 172-179.

Rangaraj Narayanan, Matthew Hoffmann, Gondi Kumar and Sekhar Surapaneni


DOI: 10.2174/1872312810666160729124745


The Role of Placental Carbonyl Reducing Enzymes in Biotransformation of Bupropion and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone

, 2017; 11(1): 29-34.

Valentina M. Fokina, Svetlana L. Patrikeeva, Cheryl Oncken, Gary D.V. Hankins, Mahmoud S. Ahmed and Tatiana Nanovskaya*


DOI: 10.2174/1872312811666170607095202


Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836


Inhibitory Effect of Fruit Juices on the Doxorubicin Metabolizing Activity of Carbonyl Reductase 1

, 2017; 11(1): 48-52.

Takeshi Miura*, Katsutoshi Nagai, Shingo Kaneshiro, Ayako Taketomi, Toshikatsu Nakabayashi, Hiroki Konishi, Toru Nishinaka and Tomoyuki Terada


DOI: 10.2174/1872312811666170309153025


Obesity and Inflammation and Altered Clopidogrel Pharmacokinetics and Pharmacodynamics

, 2017; 11(1): 3-13.

Nicholas B. Norgard* and Scott V. Monte


DOI: 10.2174/1872312811666170301110349


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