Most Accessed Articles

Transactivation Assays that Identify Indirect and Direct Activators of Human Pregnane X Receptor (PXR, NR1I2) and Constitutive Androstane Receptor (CAR, NR1I3)

, 2017; 11(2): 128-137.

Marija Pinne*, Elsa Ponce and Judy L. Raucy


DOI: 10.2174/1872312812666171207113639


The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters

, 2017; 11(2): 111-118.

Jonathan Cheong, Jason S. Halladay, Emile Plise, Jasleen K. Sodhi and Laurent Salphati*


DOI: 10.2174/1872312811666171010101248


Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4] triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy: Evidence of Glyoxal Intermediate Involvement

, 2017; 11(2): 144-148.

Mithat Gunduz*, Amanda L. Cirello, Peter Klimko, Jennifer L. Dumouchel and Upendra A. Argikar


DOI: 10.2174/1872312811666171106151730


A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays

, 2016; 10(4): 264-269.

Siva P. Putluru*, Murali K. Matta, Deepak Ahire, Murali Subramanian, Michael Sinz and Sandhya Mandlekar


DOI: 10.2174/1872312810666161124143522


Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)

, 2017; 11(1): 21-28.

Ryan H. Takahashi, Cyrus Khojasteh, Matthew Wright, Cornelis E.C.A. Hop and Shuguang Ma*


DOI: 10.2174/1872312811666170710193229


Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat

, 2017; 11(2): 102-110.

Jennifer L. Dumouchel*, Upendra A. Argikar, Jaimie Spear, Ann Brown, Christine E. Dunne, Valerie M. Kramlinger, Amanda L. Cirello and Mithat Gunduz


DOI: 10.2174/1872312811666170911122919


Application of a “Fit for Purpose” PBPK Model to Investigate the CYP3A4 Induction Potential of Enzalutamide

, 2016; 10(3): 172-179.

Rangaraj Narayanan, Matthew Hoffmann, Gondi Kumar and Sekhar Surapaneni


DOI: 10.2174/1872312810666160729124745


Evaluation of Farnesoid X Receptor Target Gene Induction in Human Hepatocytes: Amino Acid Conjugation

, 2017; 11(2): 138-143.

Jean Simmermacher* and Michael Sinz


DOI: 10.2174/1872312812666171227213946


A Pharmacokinetic-Pharmacodynamic Model of Tamoxifen and Endoxifen to Predict Their Distribution and Effects on Inhibition of Tumor Growth

, 2017; 11(2): 93-101.

Shengyue Yuan, Qingrong Sun, Yao Chen and Jun Liao*


DOI: 10.2174/1872312811666170815160751


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