Drug Metabolism Letters
Volume 15, 3 Issues, 2022
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access
Editor's Choice
The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles
, 2021; 14(2): 126 - 136Yohannes Teffera*, Jingzhou Liu, Paul Krolikowski and Zhiyang Zhao
DOI: 10.2174/1872312814666210405101419
Carbon-carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: α-ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine
, 2021; 14(1): 41 - 53Yiding Hu*, Yi Xiao, Zhesui Rao, Vasant Kumar, Hanlan Liu and Chuang Lu
DOI: 10.2174/1872312813666191125095818
A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery
, 2019; 13(2): 78 - 94Liyue Huang*, Mary C. Wells and Zhiyang Zhao
DOI: 10.2174/1872312813666190311125652
Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study
, 2019; 13(1): 37 - 44Ryan H. Takahashi*, Jae H. Chang, Jodie Pang, Xiaorong Liang and Shuguang Ma
DOI: 10.2174/1872312813666181129162237
New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation
, 2018; 12(2): 84 - 92Mithat Gunduz*, Upendra A. Argikar, Amanda L. Cirello and Jennifer L. Dumouchel
DOI: 10.2174/1872312812666180611113656
Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues
, 2018; 12(1): 24 - 32Khondoker Alam, Taleah Farasyn, Kai Ding and Wei Yue*
DOI: 10.2174/1872312812666180326110146
Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4] triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy: Evidence of Glyoxal Intermediate Involvement
, 2017; 11(2): 144 - 148Mithat Gunduz*, Amanda L. Cirello, Peter Klimko, Jennifer L. Dumouchel and Upendra A. Argikar
DOI: 10.2174/1872312811666171106151730
Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)
, 2017; 11(1): 21 - 28Ryan H. Takahashi, Cyrus Khojasteh, Matthew Wright, Cornelis E.C.A. Hop and Shuguang Ma*
DOI: 10.2174/1872312811666170710193229
A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds
, 2016; 10(1): 3 - 15Chi-Chi Peng, Utkarsh Doshi, Chandra Prakash and Albert P. Li
DOI: 10.2174/1872312809666150818111500
Adverse Drug Events in Children: How Big is the Problem?
, 2015; 9(2): 109 - 110Peter J. Zed
DOI: 10.2174/1872312809666150904182455
Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays
, 2015; 9(1): 3 - 7Norie Murayama, Takashi Usui, Nicky Slawny, Christophe Chesne and Hiroshi Yamazaki
DOI: 10.2174/1872312809666150119104806
Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes
, 2014; 8(2): 77 - 87Laura Mattinen, Jenni Kublbeck, Oona Rechardt, Paavo Honkakoski and Jari Rautio
DOI: 10.2174/1872312808666140606101422
Comparison of Catalytic Properties of Cytochromes P450 3A4 and 3A5 by Molecular Docking Simulation
, 2014; 8(1): 43 - 50Toshiro Niwa, Motohiro Yasumura, Norie Murayama and Hiroshi Yamazaki
DOI: 10.2174/1872312807666131229121228
Editor-in-Chief
Zhiyang Zhao
Alliance Pharma
Malvern, PA
(USA)
Biography
Alliance Pharma
Malvern, PA
Biography
Biography of Zhiyang Zhao
Zhiyang Zhao received his Ph.D. degree in Medicinal Chemistry from Virginia Tech, Blacksburg, Virginia, USA. Dr. Zhao’s biopharmaceutical/pharmaceutical work experience encompasses over 25 years of research in metabolic and pharmacokinetic properties of compounds for drug discovery and development at Pfizer, GlaxoSmithKline and Amgen. Currently, Dr. Zhao serves as Chief Scientific Officer (CSO) at Alliance Pharma, Inc. and is appointed as an adjunct professor at the School of Pharmacy, the University of North Carolina at Chapel Hill. Dr. Zhao has published over 50 peer-reviewed original research papers and patents in the areas of new drug targets, drug metabolism, pharmacokinetics, and toxicology.
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Journal History
Drug Metabolism Letters was launched in 2007. Dr. Zhiyang Zhao serves as the Editor-in-Chief of the journal.
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