Drug Metabolism Letters
Continued as: Drug Metabolism and Bioanalysis Letters
Volume 15, 3 Issues, 2022
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access
Editor's Choice
The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles
, 2021; 14(2): 126 - 136Yohannes Teffera*, Jingzhou Liu, Paul Krolikowski and Zhiyang Zhao
DOI: 10.2174/1872312814666210405101419
Carbon-carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: α-ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine
, 2021; 14(1): 41 - 53Yiding Hu*, Yi Xiao, Zhesui Rao, Vasant Kumar, Hanlan Liu and Chuang Lu
DOI: 10.2174/1872312813666191125095818
A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery
, 2019; 13(2): 78 - 94Liyue Huang*, Mary C. Wells and Zhiyang Zhao
DOI: 10.2174/1872312813666190311125652
Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study
, 2019; 13(1): 37 - 44Ryan H. Takahashi*, Jae H. Chang, Jodie Pang, Xiaorong Liang and Shuguang Ma
DOI: 10.2174/1872312813666181129162237
New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation
, 2018; 12(2): 84 - 92Mithat Gunduz*, Upendra A. Argikar, Amanda L. Cirello and Jennifer L. Dumouchel
DOI: 10.2174/1872312812666180611113656
Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues
, 2018; 12(1): 24 - 32Khondoker Alam, Taleah Farasyn, Kai Ding and Wei Yue*
DOI: 10.2174/1872312812666180326110146
Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4] triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy: Evidence of Glyoxal Intermediate Involvement
, 2017; 11(2): 144 - 148Mithat Gunduz*, Amanda L. Cirello, Peter Klimko, Jennifer L. Dumouchel and Upendra A. Argikar
DOI: 10.2174/1872312811666171106151730
Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)
, 2017; 11(1): 21 - 28Ryan H. Takahashi, Cyrus Khojasteh, Matthew Wright, Cornelis E.C.A. Hop and Shuguang Ma*
DOI: 10.2174/1872312811666170710193229
A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds
, 2016; 10(1): 3 - 15Chi-Chi Peng, Utkarsh Doshi, Chandra Prakash and Albert P. Li
DOI: 10.2174/1872312809666150818111500
Adverse Drug Events in Children: How Big is the Problem?
, 2015; 9(2): 109 - 110Peter J. Zed
DOI: 10.2174/1872312809666150904182455
Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays
, 2015; 9(1): 3 - 7Norie Murayama, Takashi Usui, Nicky Slawny, Christophe Chesne and Hiroshi Yamazaki
DOI: 10.2174/1872312809666150119104806
Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes
, 2014; 8(2): 77 - 87Laura Mattinen, Jenni Kublbeck, Oona Rechardt, Paavo Honkakoski and Jari Rautio
DOI: 10.2174/1872312808666140606101422
Comparison of Catalytic Properties of Cytochromes P450 3A4 and 3A5 by Molecular Docking Simulation
, 2014; 8(1): 43 - 50Toshiro Niwa, Motohiro Yasumura, Norie Murayama and Hiroshi Yamazaki
DOI: 10.2174/1872312807666131229121228
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