Track your manuscript:


Browse Contents
Select Volume:  

Select Issue:  

Select Article:


Special Offers


Articles submitted between January 01st to December 31st, 2018 will be published as Open Access. Open Access publishing provides greater accessibility to the article. To view some of the Open access articles in the journal, please click here



Quick processing and publication of the submitted papers. The manuscript will be published online within 20 days of final acceptance.



30% discount on the single-issue cost to authors on the purchase of issue(s) in which their article is published. Multiple issue copies at discounted rates.



Abstracted/Indexed in




Forthcoming Special Issues
Please visit again after some time to view these Issues.
Special Issues - In-Press
Please visit again after some time to view these Issues.
Published Special Issues
Please visit again after some time to view these Issues.
Authors' Comments
My experience of working with Bentham Science has been positive. I think the review was completed timely and handled in a very professional manner, which is very important.

Dr. Pollen K. Yeung
(Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculties of Health Professions and Medicine, Dalhousie University, Halifax, NS, )


Drug Metabolism Letters

,

Volume 12

-

Number 1



Biography   Open Access



Preface   Open Access



Research Article

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

, 12(1): 3 - 13

Susan Wong, Utkarsh Doshi, Peter Vuong , Ning Liu, Suzanne Tey, Hoa Le, Mika Kosaka, Jane R. Kelly, Albert P. Li and Zhengyin Yan*


DOI: 10.2174/1872312812666171213114422




Research Article



Research Article



Research Article



Research Article

LC-MS/MS Identification and Structural Characterization of Main Biodegradation Products of Nitroproston - A Novel Prostaglandin-based Pharmaceutical Compound

, 12(1): 54 - 61

Natalia V. Mesonzhnik*, Natalia E. Moskaleva, Ksenia M. Shestakova, Ksenya O. Kurynina, Pavel A. Baranov, Natalia M. Gretskaya, Igor V. Serkov, Igor I. Lyubimov, Vladimir V. Bezuglov and Svetlana A. Appolonova


DOI: 10.2174/1872312812666180309160927




Research Article

Evaluation of Herb-Drug Interaction of Synacinn™ and Individual Biomarker through Cytochrome 450 Inhibition Assay

, 12(1): 62 - 67

Nur Syukriah Ab Rahman, Fadzilah Adibah Abd Majid*, Mohd Effendy Abd Wahid, Ain Nabihah Zainudin, Siti Nurazwa Zainol, Hassan Fahmi Ismail, Tet Soon Wong, Nirbhay Kumar Tiwari and Sanjeev Giri


DOI: 10.2174/1872312812666180314112457




Articles Ahead of Print





Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line


Sandra Regina Lepri , Daniele Sartori , Simone Cristine Semprebon*, Adrivanio Baranoski , Giuliana Castello Coatti and Mario Sergio Mantovani


View Abstract View on PubMed




Letter to the Editor: Alam K et al. (2017) Drug Metabolism Letters; 11, 000-000.


Tristan M. Sissung, Cindy Chau, Douglas K. Price and William D. Figg*







Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Editor's Choice









Open Access Articles


The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells

, 2016; 10(4): 295 - 305

Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama




Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

, 2016; 10(2): 91 - 100

Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright




Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83 - 90

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam





Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

, 2016; 10(2): 144 - 150

Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam





Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers

, 2008; 2(2): 76 - 82

Nicolas Ansermot, Michela Rebsamen, Jocelyne Chabert, Marc Fathi, Marianne Gex-Fabry, Youssef Daali, Marie Besson, Michel Rossier, Serge Rudaz, Denis Hochstrasser, Pierre Dayer and Jules Desmeules




Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

, 2008; 2(2): 138 - 145

Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge





Most Cited Articles

Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions

, 2016; 10(1): 38-48.

Florence Namour*, Julie Desrivot, Annegret Van der Aa, Pille Harrison, Chantal Tasset and Gerben van`t Klooster


DOI: 10.2174/1872312810666151223103353


Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

, 2015; 9(2): 119-131.

Ben-Quan Shen, Daniela Bumbaca, Qin Yue, Ola Saad, Jay Tibbitts, S. Cyrus Khojasteh and Sandhya Girish


DOI: 10.2174/1872312809666150602151922




In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities

, 2015; 9(1): 48-62.

Charles Awortwe, Vamshi K. Manda, Cristina Avonto, Shabana I. Khan, Ikhlas A. Khan, Larry A. Walker, Patrick J. Bouic and Bernd Rosenkranz


DOI: 10.2174/1872312809666150119110200


Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836




Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

, 2016; 10(2): 136-143.

Hoa Le, Peter W. Fan, Susan Wong, Shuguang Ma, James P. Driscoll, Cornelis E.C.A. Hop and S. Cyrus Khojasteh


DOI: 10.2174/1872312810666160427104954




Most Accessed Articles


Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

, 2018; 12(1): 3-13.

Susan Wong, Utkarsh Doshi, Peter Vuong, Ning Liu, Suzanne Tay, Hoa Le, Mika Kosaka, Jane R. Kenny, Albert P. Li and Zhengyin Yan*


DOI: 10.2174/1872312812666171213114422




Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836


The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters

, 2017; 11(2): 111-118.

Jonathan Cheong, Jason S. Halladay, Emile Plise, Jasleen K. Sodhi and Laurent Salphati*


DOI: 10.2174/1872312811666171010101248






Webmaster Contact: info@benthamscience.org
Copyright © 2018 Bentham Science | Privacy Policy