Contents

Current Topics in Medicinal Chemistry, Volume 9 - Number 18

Editorial [Hot topic: Fragment-Based Methods in Drug Discovery: Its the Small Things that Matter (Guest Editors: Rob L.M. van Montfort and Ian Collins)]

, 9(18): 1676 - 1677

Rob L.M. van Montfort and Ian Collins


DOI: 10.2174/156802609790102428




Fragment-Based Cocktail Crystallography by the Medical Structural Genomics of Pathogenic Protozoa Consortium

, 9(18): 1678 - 1687

Christophe L.M.J. Verlinde, Erkang Fan, Sayaka Shibata, Zhongsheng Zhang, Zhihua Sun, Wei Deng, Jennifer Ross, Jessica Kim, Liren Xiao, Tracy L. Arakaki, Jurgen Bosch, Jonathan M. Caruthers, Eric T. Larson, Isolde LeTrong, Alberto Napuli, Angela Kelley, Natasha Mueller, Frank Zucker, Wesley C. Van Voorhis, Frederick S. Buckner, Ethan A. Merritt and Wim G.J. Hol


DOI: 10.2174/156802609790102383




Start Small and Stay Small: Minimizing Attrition in the Clinic with a Focus on CNS Therapeutics

, 9(18): 1688 - 1704

Vicki Nienaber


DOI: 10.2174/156802609790102374




Fragment-Based Discovery of Inhibitors of Protein Kinase B

, 9(18): 1705 - 1717

Thomas G. Davies, Steven J. Woodhead and Ian Collins


DOI: 10.2174/156802609790102419




Hit Triage Using Efficiency Indices after Screening of Compound Libraries in Drug Discovery

, 9(18): 1718 - 1724

Allen B. Reitz, Garry R. Smith, Brett A. Tounge and Charles H. Reynolds


DOI: 10.2174/156802609790102365




Fragment Library Screening and Lead Characterization Using SPR Biosensors

, 9(18): 1725 - 1735

U. Helena Danielson


DOI: 10.2174/156802609790102392




Target Immobilization and NMR Screening of Fragments in Early Drug Discovery

, 9(18): 1736 - 1745

Gregg Siegal and Johan G. Hollander


DOI: 10.2174/156802609790102400




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