Contents

Current Topics in Medicinal Chemistry, Volume 9 - Number 15

Editorial [Hot topic: Inhibition and Function of Heat Shock Proteins 70 and 90 (Guest Editor: Brian S. J. Blagg)]

, 9(15): 1335 - 1336

Brian S. J. Blagg


DOI: 10.2174/156802609789895746




Pharmacological Targeting of the Hsp70 Chaperone

, 9(15): 1337 - 1351

Srikanth Patury, Yoshinari Miyata and Jason E. Gestwicki


DOI: 10.2174/156802609789895674




Strategies for Stalling Malignancy: Targeting Cancers Addiction to Hsp90

, 9(15): 1352 - 1368

Chrisostomos Prodromou


DOI: 10.2174/156802609789895656




Structural and Computational Biology of the Molecular Chaperone Hsp90: From Understanding Molecular Mechanisms to Computer-Based Inhibitor Design

, 9(15): 1369 - 1385

Gennady M. Verkhivker, Anshuman Dixit, Giulia Morra and Giorgio Colombo


DOI: 10.2174/156802609789895700




Ansamycin Inhibitors of Hsp90: Natures Prototype for Anti-Chaperone Therapy

, 9(15): 1386 - 1418

James R. Porter, Jie Ge, John Lee, Emmanuel Normant and Kip West


DOI: 10.2174/156802609789895719




Hsp90 Inhibition with Resorcylic Acid Lactones (RALs)

, 9(15): 1419 - 1435

Nicolas Winssinger, Jean-Gonzague Fontaine and Sofia Barluenga


DOI: 10.2174/156802609789895665




Purine-Scaffold Hsp90 Inhibitors

, 9(15): 1436 - 1446

Tony Taldone and Gabriela Chiosis


DOI: 10.2174/156802609789895737




Alternate Strategies of Hsp90 Modulation for the Treatment of Cancer and Other Diseases

, 9(15): 1447 - 1461

Gary E. L. Brandt and Brian S. J. Blagg


DOI: 10.2174/156802609789895683




Assays for Identification of Hsp90 Inhibitors and Biochemical Methods for Discriminating their Mechanism of Action

, 9(15): 1462 - 1478

Robert L. Matts and Jacob R. Manjarrez


DOI: 10.2174/156802609789895692




Update on Hsp90 Inhibitors in Clinical Trial

, 9(15): 1479 - 1492

Y. S. Kim, S. V. Alarcon, S. Lee, M.-J. Lee, G. Giaccone, L. Neckers and J. B. Trepel


DOI: 10.2174/156802609789895728




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