Contents

Current Topics in Medicinal Chemistry, Volume 9 - Number 13

Editorial [Hot topic: Medicinal Chemistry in the Pilot Phase of the Molecular Libraries Screening Center Network (Guest Editor: Donna M. Huryn)]

, 9(13): 1158

Donna M. Huryn


DOI: 10.2174/156802609789753626




Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining

, 9(13): 1159 - 1171

Pahk Thepchatri, Jaeki Min, Thota Ganesh, Yuhong Du, Iestyn Lewis, Serdar Kurtkaya, Andrew Prussia, Lian Li, Blossom Sneed, Richard K. Plemper, Haian Fu, Dennis C. Liotta, James P. Snyder, Raymond Dingledine and Aiming Sun


DOI: 10.2174/156802609789753581




Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay

, 9(13): 1172 - 1180

Yuli Xie, Alison Rinderspacher, Yidong Liu, Gangli Gong, Deborah H. Smith, Michael Wyler, Lars Branden and Shi-Xian Deng


DOI: 10.2174/156802609789753617




The Pilot Phase of the NIH Chemical Genomics Center

, 9(13): 1181 - 1193

Craig J. Thomas, Douglas S. Auld, Ruili Huang, Wenwei Huang, Ajit Jadhav, Ronald L. Johnson, William Leister, David J. Maloney, Juan J. Marugan, Sam Michael, Anton Simeonov, Noel Southall, Menghang Xia, Wei Zheng, James Inglese and Christopher P. Austin


DOI: 10.2174/156802609789753644




A Case Study from the Chemistry Core of the Pittsburgh Molecular Library Screening Center: The Polo-like Kinase Polo-Box Domain (Plk1- PBD)

, 9(13): 1194 - 1205

Peter Wipf, David Arnold, Karen Carter, Shuzhi Dong, Paul A. Johnston, Elizabeth Sharlow, John S. Lazo and Donna H. Huryn


DOI: 10.2174/156802609789753590




The Identification, Characterization and Optimization of Small Molecule Probes of Cysteine Proteases: Experiences of the Penn Center for Molecular Discovery with Cathepsin B and Cathepsin L

, 9(13): 1206 - 1216

Donna M. Huryn and Amos B. Smith III


DOI: 10.2174/156802609789753653




Discovery and Development of a Potent and Highly Selective Small Molecule Muscarinic Acetylcholine Receptor Subtype I (mAChR 1 or M1) Antagonist In Vitro and In Vivo Probe

, 9(13): 1217 - 1226

C. David Weaver, Douglas J. Sheffler, L. Michelle Lewis, Thomas M. Bridges, Richard Williams, Natalia T. Nalywajko, J. Phillip Kennedy, Matthew M. Mulder, Satyawan Jadhav, Leslie A. Aldrich, Carrie K. Jones, Joy Marlo, Colleen M. Niswender, Matthew M. Mock, Fang Zheng, P. Jeffrey Conn and Craig W. Lindsley


DOI: 10.2174/156802609789753635




Discovery of Selective Probes and Antagonists for G Protein-Coupled Receptors FPR/FPRL1 and GPR30

, 9(13): 1227 - 1236

Jeffrey B. Arterburn, Tudor I. Oprea, Eric R. Prossnitz, Bruce S. Edwards and Larry A. Sklar


DOI: 10.2174/156802609789753608




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