Contents

Current Topics in Medicinal Chemistry, Volume 7 - Number 4

Editorial [ Hot Topic : Receptor Dimerization and Bivalent Ligands, an Emerging Topic for Drug Design (Guest Editor: Dr. Ao Zhang) ]

, 7(4): 341

Ao Zhang and John L. Neumeyer


DOI: 10.2174/156802607779941189




Receptor Dimerization - Rationale for the Design of Bivalent Ligands

, 7(4): 343 - 345

Ao Zhang, Zhili Liu and Ying Kan


DOI: 10.2174/156802607779941279




Agonistic and Antagonistic Bivalent Ligands for Serotonin and Dopamine Receptors Including their Transporters

, 7(4): 347 - 353

Michael Decker and Jochen Lehmann


DOI: 10.2174/156802607779941297




Probing the Membrane Targeting C1 Subdomains of PKC with Bivalent Ligands

, 7(4): 355 - 362

Ireneusz Nowak


DOI: 10.2174/156802607779941260




Kappa Receptor Bivalent Ligands

, 7(4): 363 - 373

Xuemei Peng and John L. Neumeyer


DOI: 10.2174/156802607779941251




Bivalent Ligands Derived from Huperzine A as Acetylcholinesterase Inhibitors

, 7(4): 375 - 387

H. Haviv, D. M. Wong, I. Silman and J. L. Sussman


DOI: 10.2174/156802607779941215




Editorial [ Hot Topic : Viagras Cousins - Towards a New Generation of Phosphodiesterase Inhibitors (Guest Editor: Philip Thompson) ]

, 7(4): 389

Philip Thompson


DOI: 10.2174/156802607779941206




Crystal Structures of Phosphodiesterases and Implications on Substrate Specificity and Inhibitor Selectivity

, 7(4): 391 - 403

Hengming Ke and Huanchen Wang


DOI: 10.2174/156802607779941242




Design of Second Generation Phosphodiesterase 5 Inhibitors

, 7(4): 405 - 419

Michael J. Palmer, Andrew S. Bell, David N. A. Fox and David G. Brown


DOI: 10.2174/156802607779941288




Re-Discovering PDE3 Inhibitors - New Opportunities for a Long Neglected Target

, 7(4): 421 - 436

Philip E. Thompson, Vincent Manganiello and Eva Degerman


DOI: 10.2174/156802607779941224




The Novel Functions of cGMP-Specific Phosphodiesterase 5 and its Inhibitors in Carcinoma Cells and Pulmonary/Cardiovascular Vessels

, 7(4): 437 - 454

Bing Zhu and Samuel J Strada


DOI: 10.2174/156802607779941198




Corrigendum

, 7(4): 455


DOI: 10.2174/156802607779941233




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