Contents

Current Topics in Medicinal Chemistry, Volume 7 - Number 14

Editorial [Hot Topic: Targeting Protein Kinases in Drug Discovery and Medicinal Chemistry (Guest Editor: Jeffrey Jie-Lou Liao)]

, 7(14): 1331

Liao Jie-Lou Jeffrey


DOI: 10.2174/156802607781696828




Molecular Targeting of Protein Kinases to Optimize Selectivity and Resistance Profiles of Kinase Inhibitors

, 7(14): 1332 - 1335

Liao Jie-Lou Jeffrey


DOI: 10.2174/156802607781696800




The Role of Halogen Bonding in Inhibitor Recognition and Binding by Protein Kinases

, 7(14): 1336 - 1348

Voth Regier Andrea and Ho Shing P.


DOI: 10.2174/156802607781696846




Recent Progress in the Development of ATP-Competitive and Allosteric Akt Kinase Inhibitors

, 7(14): 1349 - 1363

Lindsley W. Craig, Barnett F. Stanley, Yaroschak Melissa, Bilodeau T. Mark and Layton E. Mark


DOI: 10.2174/156802607781696864




Recent Advances of MEK Inhibitors and Their Clinical Progress

, 7(14): 1364 - 1378

Wang John (Yuan), Wilcoxen M. Keith, Nomoto Kenichi and Wu Sara


DOI: 10.2174/156802607781696837




Molecular Design and Clinical Development of VEGFR Kinase Inhibitors

, 7(14): 1379 - 1393

Zhong Haizhen and Bowen Phillip J.


DOI: 10.2174/156802607781696855




Targeting Protein Multiple Conformations: A Structure-Based Strategy for Kinase Drug Design

, 7(14): 1394 - 1407

Liao Jie-Lou Jeffrey and Andrews C. Robert


DOI: 10.2174/156802607781696783




A Comparison of Physicochemical Property Profiles of Marketed Oral Drugs and Orally Bioavailable Anti-Cancer Protein Kinase Inhibitors in Clinical Development

, 7(14): 1408 - 1422

Gill L. Adrian, Verdonk Marcel, Boyle G. Robert and Taylor Richard


DOI: 10.2174/156802607781696819




Molecule of the Month

, 7(14): 1423

Shotwell Brad J.


DOI: 10.2174/156802607781696792




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