Contents

Current Topics in Medicinal Chemistry, Volume 7 - Number 10

Editorial [Hot Topic: Small Molecule Inhibition of Protein-Protein Interaction:An Emerging Paradigm in Drug Design (Guest Editor: Craig W. Lindsley)]

, 7(10): 921

Craig W. Lindsley


DOI: 10.2174/156802607780906780




Protein-Protein Interaction Inhibitors: Small Molecules from Screening Techniques

, 7(10): 922 - 927

Steven Fletcher and Andrew D. Hamilton


DOI: 10.2174/156802607780906735




Scaffolds for Blocking Protein-Protein Interactions

, 7(10): 928 - 942

Stefan J. Hershberger, Song-Gil Lee and Jean Chmielewski


DOI: 10.2174/156802607780906726




Towards Drugs Targeting Multiple Proteins in a Systems Biology Approach

, 7(10): 943 - 951

O. Keskin, A. Gursoy, B. Ma and R. Nussinov


DOI: 10.2174/156802607780906690




Small Molecule Protein-Protein Inhibitors for the p53-MDM2 Interaction

, 7(10): 952 - 960

Anna S. Dudkina and Craig W. Lindsley


DOI: 10.2174/156802607780906762




Small Molecule Inhibition of the Bcl-XL-BH3 Protein-Protein Interaction: Proof-of-Concept of an In Vivo Chemopotentiator ABT-737

, 7(10): 961 - 965

Shaun R. Stauffer


DOI: 10.2174/156802607780906843




Small Molecule Inhibitors of the XIAP Protein-Protein Interaction

, 7(10): 966 - 971

Hemaka A. Rajapakse


DOI: 10.2174/156802607780906816




Disruption of the Keap1-Containing Ubiquitination Complex as an Antioxidant Therapy

, 7(10): 972 - 978

Jonathan T. Kern, Mark Hannink and J. Fred Hess


DOI: 10.2174/156802607780906825




Editorial [Hot Topic: Computational Approaches in Medicinal Chemistry and Drug Discovery (Guest Editor: Dr. Fredy Sussman)]

, 7(10): 979

Fredy Sussman


DOI: 10.2174/156802607780906834




The Search for Drug Leads Targeted to the β -Secretase: An Example of the Roles of Computer Assisted Approaches in Drug Discovery

, 7(10): 980 - 990

M. Carmen Villaverde, Lucia Gonzalez-Louro and Fredy Sussman


DOI: 10.2174/156802607780906708




Structural Models of Class A G Protein-Coupled Receptors as a Tool for Drug Design: Insights on Transmembrane Bundle Plasticity

, 7(10): 991 - 998

Xavier Deupi, Nicole Dolker, Maria Luz Lopez-Rodriguez, Mercedes Campillo, Juan A. Ballesteros and Leonardo Pardo


DOI: 10.2174/156802607780906799




Trp/Met/Phe Hot Spots in Protein-Protein Interactions: Potential Targets in Drug Design

, 7(10): 999 - 1005

Buyong Ma and Ruth Nussinov


DOI: 10.2174/156802607780906717




Ligand Docking and Structure-based Virtual Screening in Drug Discovery

, 7(10): 1006 - 1014

Claudio N. Cavasotto and Andrew J. W. Orry


DOI: 10.2174/156802607780906753




Medicinal Chemistry and Bioinformatics - Current Trends in Drugs Discovery with Networks Topological Indices

, 7(10): 1015 - 1029

Humberto Gonzalez-Diaz, Santiago Vilar, Lourdes Santana and Eugenio Uriarte


DOI: 10.2174/156802607780906771




Structure Based Drug Design for HIV Protease: From Molecular Modeling to Cheminformatics

, 7(10): 1030 - 1038

Patra Volarath, Robert W. Harrison and Irene T. Weber


DOI: 10.2174/156802607780906744




Molecule of the Month

, 7(10): 1039

R. Nathan Daniels and Craig W. Lindsley


DOI: 10.2174/156802607780906807




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