Contents

Current Topics in Medicinal Chemistry, Volume 6 - Number 5

Editorial [Hot Topic:Successful Drug Discovery: Rules and Examples (Guest Editor: Dr. David C. Swinney)]

, 6(5): 403 - 404

David C. Swinney


DOI: 10.2174/156802606776743110




Discovery and Clinical Development of Dutasteride, a Potent Dual 5α- Reductase Inhibitor

, 6(5): 405 - 421

Stephen V. Frye


DOI: 10.2174/156802606776743101




Optimization of Small Molecule Drugs Binding to Highly Polar Target Sites: Lessons from the Discovery and Development of Neuraminidase Inhibitors

, 6(5): 423 - 434

Klaus Klumpp and Bradford J. Graves


DOI: 10.2174/156802606776743138




Lessons from the Drug Discovery of Lapatinib, a Dual ErbB1/2 Tyrosine Kinase Inhibitor

, 6(5): 435 - 460

Karen E. Lackey


DOI: 10.2174/156802606776743156




Biochemical Mechanisms of New Molecular Entities (NMEs) Approved by United States FDA During 2001-2004: Mechanisms Leading to Optimal Efficacy and Safety

, 6(5): 461 - 478

David C. Swinney


DOI: 10.2174/156802606776743093




A Medicinal Chemistry Perspective on 4-Aminoquinoline Antimalarial Drugs

, 6(5): 479 - 507

Patrick G. Bray, B. K. Park, Egbaleh Asadollaly, Giancarlo A. Biagini, J. P. Jeyadevan, Neil G. Berry, Stephen A. Ward and Paul M. O' Neill


DOI: 10.2174/156802606776743147




From Artemisinin to New Artemisinin Antimalarials: Biosynthesis, Extraction, Old and New Derivatives, Stereochemistry and Medicinal Chemistry Requirements

, 6(5): 509 - 537

Richard K. Haynes


DOI: 10.2174/156802606776743129




Mechanisms of Drug Action and Drug Resistance in Leishmania as Basis for Therapeutic Target Identification and Design of Antileishmanial Modulators

, 6(5): 539 - 550

Philippe M. Loiseau and Christian Bories


DOI: 10.2174/156802606776743165




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