Contents

Current Topics in Medicinal Chemistry, Volume 6 - Number 14

Editorial [ The Use of Selective Fluorination in Drug Design and Development Guest Editor: Dr. Kenneth L. Kirk ]

, 6(14): 1445

Kenneth L. Kirk


DOI: 10.2174/156802606777951118




Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales

, 6(14): 1447 - 1456

Kenneth L. Kirk


DOI: 10.2174/156802606777951073




Fluorinated Molecules as Drugs and Imaging Agents in the CNS

, 6(14): 1457 - 1464

Shengguo Sun and Adeboye Adejare


DOI: 10.2174/156802606777951046




Design and Synthesis of Phosphonodifluoromethyl Phenylalanine (F2Pmp):A Useful Phosphotyrosyl Mimetic

, 6(14): 1465 - 1471

Terrence R. Burke


DOI: 10.2174/156802606777951091




The Strength of Weak Interactions: Aromatic Fluorine in Drug Design

, 6(14): 1473 - 1482

Stephen G. DiMagno and Haoran Sun


DOI: 10.2174/156802606777951127




How Cα-Fluoroalkyl Amino Acids and Peptides Interact with Enzymes:Studies Concerning the Influence on Proteolytic Stability, Enzymatic Resolution and Peptide Coupling

, 6(14): 1483 - 1498

Rene Smits and Beate Koksch


DOI: 10.2174/156802606777951055




Fluorinated Nucleosides as Antiviral and Antitumor Agents

, 6(14): 1499 - 1528

Wei-Dong Meng and Feng-Ling Qing


DOI: 10.2174/156802606777951082




Fluorinated Natural Products with Clinical Significance

, 6(14): 1529 - 1543

Craig J. Thomas


DOI: 10.2174/156802606777951109




Peptidyl Fluoro-Ketones as Proteolytic Enzyme Inhibitors

, 6(14): 1545 - 1566

Monica Sani, Roberta Sinisi and Fiorenza Viani


DOI: 10.2174/156802606777951064




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