Contents

Current Topics in Medicinal Chemistry, Volume 6 - Number 11

Editorial [ Purine Binding Proteins as Anti-Cancer Targets Guest Editor: Dr. Zhenhai Gao ]

, 6(11): 1069

Zhenhai Gao


DOI: 10.2174/156802606777811988




Recent Advances in the Research and Development of RAF Kinase Inhibitors

, 6(11): 1071 - 1089

Roger A. Smith, Jacques Dumas, Lila Adnane and Scott M. Wilhelm


DOI: 10.2174/156802606777812077




Inhibitors of the HSP90 Molecular Chaperone: Attacking the Master Regulator in Cancer

, 6(11): 1091 - 1107

Edward McDonald, Paul Workman and Keith Jones


DOI: 10.2174/156802606777812004




Structure-Function Based Design of Small Molecule Inhibitors Targeting Rho Family GTPases

, 6(11): 1109 - 1116

Nicolas Nassar, Jose Cancelas, Jie Zheng, David A. Williams and Yi Zheng


DOI: 10.2174/156802606777812095




The Purinome, a Complex Mix of Drug and Toxicity Targets

, 6(11): 1117 - 1127

Timothy A. J.Haystead


DOI: 10.2174/156802606777812059




Targeting Cancer: The Challenges and Successes of Structure-Based Drug Design Against the Human Purinome

, 6(11): 1129 - 1159

Mark Knapp, Cornelia Bellamacina, Jeremy M. Murray and Dirksen E. Bussiere


DOI: 10.2174/156802606777812040




Editorial [ Molecular Chaperones as Targets in Medicinal Chemistry and Drug Discovery Guest Editor: Dr. Gabriela Chiosis ]

, 6(11): 1161

Gabriela Chiosis


DOI: 10.2174/156802606777812022




Using Natural Product Inhibitors to Validate Hsp90 as a Molecular Target in Cancer

, 6(11): 1163 - 1171

Len Neckers


DOI: 10.2174/156802606777811979




Geldanamycin, Radicicol, and Chimeric Inhibitors of the Hsp90 Nterminal ATP Binding Site

, 6(11): 1173 - 1182

M. Kyle Hadden, Donna J. Lubbers and Brian S. J. Blagg


DOI: 10.2174/156802606777812031




Discovery and Development of Purine-Scaffold Hsp90 Inhibitors

, 6(11): 1183 - 1191

Gabriela Chiosis


DOI: 10.2174/156802606777812013




Discovery and Development of Pyrazole-Scaffold Hsp90 Inhibitors

, 6(11): 1193 - 1203

Edward McDonald, Keith Jones, Paul A. Brough, Martin J. Drysdale and Paul Workman


DOI: 10.2174/156802606777812086




Hsp90: A Novel Target for Cancer Therapy

, 6(11): 1205 - 1214

David B. Solit and Neal Rosen


DOI: 10.2174/156802606777812068




Hsp70 Molecular Chaperones: Emerging Roles in Human Disease and Identification of Small Molecule Modulators

, 6(11): 1215 - 1225

Jeffrey L. Brodsky and Gabriela Chiosis


DOI: 10.2174/156802606777811997




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