Contents

Current Topics in Medicinal Chemistry, Volume 5 - Number 2

Editorial [Hot Topic: Novel Cancer Therapeutic Targets (Guest Editor: George Hartman)]

, 5(2): 107

George D. Hartman


DOI: 10.2174/1568026053507679




The Akt/PKB Family of Protein Kinases: A Review of Small Molecule Inhibitors and Progress Towards Target Validation

, 5(2): 109 - 125

Stanley F. Barnett, Mark T. Bilodeau and Craig W. Lindsley


DOI: 10.2174/1568026053507714




Mitotic Kinesins: Prospects for Antimitotic Drug Discovery

, 5(2): 127 - 145

Gustave Bergnes, Katjusa Brejc and Lisa Belmont


DOI: 10.2174/1568026053507697




The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery

, 5(2): 147 - 157

Gary V. Borzillo and Blaise Lippa


DOI: 10.2174/1568026053507732




Small Molecule Inhibitors of p53/MDM2 Interaction

, 5(2): 159 - 165

Nader Fotouhi and Bradford Graves


DOI: 10.2174/1568026053507705




Recent Advances in the Development of Selective Small Molecule Inhibitors for Cyclin-Dependent Kinases

, 5(2): 167 - 179

Hiroshi Hirai, Nobuhiko Kawanishi and Yoshikazu Iwasawa


DOI: 10.2174/1568026053507688




Progress in the Discovery of Polo-like Kinase Inhibitors

, 5(2): 181 - 197

Campbell McInnes, Mokdad Mezna and Peter M. Fischer


DOI: 10.2174/1568026053507660




Progress in the Development of Selective Inhibitors of Aurora Kinases

, 5(2): 199 - 213

Andrew Mortlock, Nicholas J. Keen, Frederic H. Jung, Nicola M. Heron, Kevin M. Foote, Robert Wilkinson and Stephen Green


DOI: 10.2174/1568026053507651




Progress Towards Therapeutic Small Molecule MEK Inhibitors for Use in Cancer Therapy

, 5(2): 215 - 229

Eli M. Wallace, Joseph P. Lyssikatos, Tammie Yeh, James D. Winkler and Kevin Koch


DOI: 10.2174/1568026053507723




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