Contents

Current Topics in Medicinal Chemistry, Volume 5 - Number 10

Editorial [Hot Topic: p38 Kinase Inhibitor (Guest Editor: Katerina Leftheris)]

, 5(10): 919

Katerina Leftheris


DOI: 10.2174/1568026054985885




The Biology of p38 Kinase: A Central Role in Inflammation

, 5(10): 921 - 928

Gary L. Schieven


DOI: 10.2174/1568026054985902




Potential Adverse Effects Associated with Inhibition of p38α/β MAP Kinases

, 5(10): 929 - 939

Donna M. Dambach


DOI: 10.2174/1568026054985911




Discovery of Highly Selective Inhibitors of p38α

, 5(10): 941 - 951

Ioana Popa-Burke, Steve Birkos, Leonard Blackwell, Lynn Cheatham, Jennifer Clark, John K. Dickson, Jr., Scott Galasinski, William P. Janzen, Jose Mendoza, Jennifer L. Miller, Robert P. Mohney, Paul M. Steed and C. N. Hodge


DOI: 10.2174/1568026054985867




The Discovery of Novel Chemotypes of p38 Kinase Inhibitors

, 5(10): 953 - 965

David J. Diller, Tsung H. Lin and Axel Metzger


DOI: 10.2174/1568026054985948




Small Molecule p38 Inhibitors: Novel Structural Features and Advances from 2002-2005

, 5(10): 967 - 985

John Hynes, Jr. and Katerina Leftheris


DOI: 10.2174/1568026054985920




P38 MAP Kinase Inhibitors: Evolution of Imidazole-Based and Pyrido- Pyrimidin-2-One Lead Classes

, 5(10): 987 - 1003

Swaminathan R. Natarajan and James B. Doherty


DOI: 10.2174/1568026054985876




Structural Comparison of p38 Inhibitor-Protein Complexes: A Review of Recent p38 Inhibitors Having Unique Binding Interactions

, 5(10): 1005 - 1016

Stephen T. Wrobleski and Arthur M. Doweyko


DOI: 10.2174/1568026054985894




Pathway to the Clinic: Inhibition of P38 MAP Kinase. A Review of Ten Chemotypes Selected for Development

, 5(10): 1017 - 1029

David M. Goldstein and Tobias Gabriel


DOI: 10.2174/1568026054985939




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