Contents

Current Topics in Medicinal Chemistry, Volume 4 - Number 4

Preface [Hot topic: Modern Aspects in the Design And Discovery of Novel Antihypertensive Drugs (Guest Editor: Thomas Mavromoustakos)]

, 4(4): i

Thomas Mavromoustakos


DOI: 10.2174/1568026043451366




Conformation and Bioactivity. Design and Discovery of Novel Antihypertensive Drugs

, 4(4): 385 - 401

T. Mavromoustakos, M. Zervou, P. Zoumpoulakis, I. Kyrikou, N. P. Benetis, L. Polevaya, P. Roumelioti, N. Giatas, A. Zoga and P. Moutevelis Minakakis


DOI: 10.2174/1568026043451302




Structural Features of Angiotensin-I Converting Enzyme Catalytic Sites: Conformational Studies in Solution, Homology Models and Comparison with Other Zinc Metallopeptidases

, 4(4): 403 - 429

Georgios A. Spyroulias, Athanassios S. Galanis, George Pairas, Evy Manessi-Zoupa and Paul Cordopatis


DOI: 10.2174/1568026043451294




On the Structural Basis of the Hypertensive Properties of Angiotensin II: A Solved Mystery or a Controversial Issue?

, 4(4): 431 - 444

Andreas G. Tzakos, Ioannis P. Gerothanassis and Anastassios N. Troganis


DOI: 10.2174/1568026043451375




Efforts to Understand the Molecular Basis of Hypertension Through Drug:Membrane Interactions

, 4(4): 445 - 459

T. Mavromoustakos, P. Zoumpoulakis, I. Kyrikou, A. Zoga, E. Siapi, M. Zervou, I. Daliani, D. Dimitriou, A. Pitsas, C. Kamoutsis and P. Laggner


DOI: 10.2174/1568026043451339




Simulating Physiology and Methods for Therapeutic Evaluation with Emphasis on Hypertension

, 4(4): 461 - 471

A. K. Macpherson and S. Neti


DOI: 10.2174/1568026043451357




Renin-angiotensin System Blockade at the Level of the Angiotensin Converting Enzyme or the Angiotensin Type-1 Receptor: Similarities and Differences

, 4(4): 473 - 481

George S. Stergiou and Irini I. Skeva


DOI: 10.2174/1568026043451320




Hematocrit-lowering Effect Following Inactivation of Renin-Angiotensin System with Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

, 4(4): 483 - 486

K. P. Marathias, B. Agroyannis, T. Mavromoustakos, J. Matsoukas and D. V. Vlahakos


DOI: 10.2174/1568026043451311




The Shift in the “Paradigm” of the Pharmacology of Hypertension

, 4(4): 487 - 498

Christodoulos S. Flordellis, Dimitrios Goumenos, George Kourounis, Sotirios A. Tsementzis, Herve Paris and Jaannis Vlachojiannis


DOI: 10.2174/1568026043451348




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