Contents

Current Topics in Medicinal Chemistry, Volume 3 - Number 10

Preface by Christopher J. Dinsmore (Hot Topic: Farnesyl-Protein Transfrase Inhibitors Guest Editor: Christopher J. Dinsmore

, 3(10): i

Christopher J. Dinsmore


DOI: 10.2174/1568026033452069




Preface by Guo Zhu Zheng

, 3(10): ii

Guo Zhu Zheng


DOI: 10.2174/1568026033452041




Use of Synthetic Isoprenoid Analogues for Understanding Protein Prenyltransferase Mechanism and Structure

, 3(10): 1043 - 1074

Tamara A. Kale, Shih-an J. Hsieh, Matt W. Rose and Mark D. Distefano


DOI: 10.2174/1568026033452087




Inhibitors of Farnesyltransferase and Geranylgeranyltransferase-I for Antitumor Therapy: Substrate-Based Design, Conformational Constraint and Biological Activity

, 3(10): 1075 - 1093

Christopher J. Dinsmore and Ian M. Bell


DOI: 10.2174/1568026033452113




Farnesyl Protein Transferase Inhibitor ZARNESTRA™ R115777 - History of a Discovery

, 3(10): 1095 - 1102

Marc Venet, David End and Patrick Angibaud


DOI: 10.2174/1568026033452050




Sch-66336 (Sarasar®) and Other Benzocycloheptapyridyl Farnesyl Protein Transferase Inhibitors: Discovery, Biology and Clinical Observations

, 3(10): 1103 - 1114

Arthur G. Taveras, Paul Kirschmeier and Charles M. Baum


DOI: 10.2174/1568026033452104




G-Protein Coupled Receptor Antagonists-1: Protease Activated Receptor-1 (PAR-1) Antagonists as Novel Cardiovascular Therapeutic Agents (Hot Topic: Structure and property Approaches in Recent Drug Discovery Guest Editor: Guo Zhu Zheng)

, 3(10): 1115 - 1123

Samuel Chackalamannil


DOI: 10.2174/1568026033452122




The Role of Absorption, Distribution, Metabolism, Excretion and Toxicity in Drug Discovery

, 3(10): 1125 - 1154

Jing Lin, Diana C. Sahakian, Sonia M. F. de Morais, Jinghai J. Xu, Robert J. Polzer and Steven M. Winter


DOI: 10.2174/1568026033452096




Structure-Activity Relationship Studies: M2 and CCR5 Receptor Antagonists

, 3(10): 1155 - 1169

Craig D. Boyle and Anandan Palani


DOI: 10.2174/1568026033452032




Theoretical Property Predictions

, 3(10): 1171 - 1192

David J. Livingstone


DOI: 10.2174/1568026033452078




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