Contents

Current Topics in Medicinal Chemistry, Volume 16 - Number 16

Editorial

Editorial (Thematic Issue: Drug Design and Discovery Targeting Ion Channels)

, 16(16): 1763

Xin Li


DOI: 10.2174/1568026616999160408164939




HCN Channels Modulators: The Need for Selectivity

, 16(16): 1764 - 1791

Maria Novella Romanelli, Laura Sartiani, Alessio Masi, Guido Mannaioni, Dina Manetti, Alessandro Mugelli and Elisabetta Cerbai


DOI: 10.2174/1568026616999160315130832





Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation

, 16(16): 1792 - 1818

Robert A. Pearlstein, K. Andrew MacCannell, Gül Erdemli, Sarita Yeola, Gabriel Helmlinger, Qi-Ying Hu, Ramy Farid, William Egan, Steven Whitebread, Clayton Springer, Jeremy Beck, Hao-Ran Wang, Mateusz Maciejewski, Laszlo Urban and José S. Duca


DOI: 10.2174/1568026616666160315142156





Computer-Aided Drug Discovery and Design Targeting Ion Channels

, 16(16): 1819 - 1829

Qiansen Zhang, Zhaobing Gao and Huaiyu Yang


DOI: 10.2174/1568026616666160315142346





Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors

, 16(16): 1830 - 1842

Alina Kassenbrock, Neil Vasdev and Steven H. Liang


DOI: 10.2174/1568026616666160315142457





Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity

, 16(16): 1843 - 1854

Xiaoke Guo, Weilin Chen, Haopeng Sun and Qidong You


DOI: 10.2174/1568026616666160315142647





HCN Channel as Therapeutic Targets for Heart Failure and Pain

, 16(16): 1855 - 1861

Ying Cao, Jianxin Pang and Pingzheng Zhou


DOI: 10.2174/1568026616666151215104058





Studies on Chloride Channels and their Modulators

, 16(16): 1862 - 1876

Vaishali M. Patil and Satya P. Gupta


DOI: 10.2174/1568026616666151215104302





Progress in Research of KV1.1 and KV1.3 Channels as Therapeutic Targets

, 16(16): 1877 - 1885

Wei Zhao and Yuan Chen


DOI: 10.2174/1568026616666160315142920





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