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Current Topics in Medicinal Chemistry, Volume 15 - Number 23


An Overview of Recent Dipeptidyl Peptidase-IV Inhibitors: Linking their Structure and Physico-Chemical Properties with SAR, Pharmacokinetics and Toxicity

, 15(23): 2342 - 2372

Andrija Smelcerovic, Filip Miljkovic, Ana Kolarevic, Jelena Lazarevic, Aleksandra Djordjevic, Gordana Kocic and Marko Anderluh


DOI: 10.2174/1568026615666150619142731



Glycogen Phosphorylase as a Target for Type 2 Diabetes: Synthetic, Biochemical, Structural and Computational Evaluation of Novel N-acyl-N´-(β-D-glucopyranosyl) Urea Inhibitors

, 15(23): 2373 - 2389

Anastassia L. Kantsadi, Vanessa Parmenopoulou, Dimitar N. Bakalov, Laura Snelgrove, George A. Stravodimos, Demetra S.M. Chatzileontiadou, Stella Manta, Angeliki Panagiotopoulou, Joseph M. Hayes, Dimitri Komiotis and Demetres D. Leonidas


DOI: 10.2174/1568026615666150619142253



Insulin Sensitivity is Modified by a Glycogen Phosphorylase Inhibitor: Glucopyranosylidene-Spiro-Thiohydantoin in Streptozotocin-Induced Diabetic Rats

, 15(23): 2390 - 2394

Tibor Docsa, Balazs Marics, Jozsef Nemeth, Csaba Huse, Laszlo Somsak, Pal Gergely and Barna Peitl


DOI: 10.2174/1568026615666150622091407



Sulfur- and Acyl Chain-Dependent Influence of 2-Methoxy-Lysophosphatidylcholine Analogues on β Pancreatic Cells

, 15(23): 2395 - 2405

Anna Drzazga, Anna Ciesielska and Edyta Gendaszewska-Darmach


DOI: 10.2174/1568026615666150619141239



Tetracyclic Triterpenoids in Herbal Medicines and their Activities in Diabetes and its Complications

, 15(23): 2406 - 2430

Kaiser Hamid, Ali Alqahtani, Moon-Sun Kim, Jun-Lae Cho, Pei H. Cui, Chun Guang Li, Paul W. Groundwater and George Q. Li


DOI: 10.2174/1568026615666150619141940



Antidiabetic Effect of Polyphenolic Extracts from Selected Edible Plants as α-Amylase, α -Glucosidase and PTP1B Inhibitors, and β Pancreatic Cells Cytoprotective Agents - A Comparative Study

, 15(23): 2431 - 2444

Małgorzata Zakłos-Szyda, Iwona Majewska, Małgorzata Redzynia and Maria Koziołkiewicz


DOI: 10.2174/1568026615666150619143051



Curcumin: A Natural Product for Diabetes and its Complications

, 15(23): 2445 - 2455

Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad and Seyed Mohammad Nabavi


DOI: 10.2174/1568026615666150619142519



Anti-inflammatory Glycosylated Flavonoids as Therapeutic Agents for Treatment of Diabetes-Impaired Wounds

, 15(23): 2456 - 2463

Marilena Antunes-Ricardo, Janet Gutierrez-Uribe and Sergio O. Serna-Saldivar


DOI: 10.2174/1568026615666150619141702



Proangiogenic Properties of Nucleoside 5'-O-Phosphorothioate Analogues Under Hyperglycaemic Conditions

, 15(23): 2464 - 2474

Edyta Węgłowska, Marcin Szustak and Edyta Gendaszewska-Darmach


DOI: 10.2174/1568026615666150619142859




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