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Contents

Current Topics in Medicinal Chemistry, Volume 14 - Number 11


In Vitro Human Hepatocyte-Based Experimental Systems for the Evaluation of Human Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity in Drug Development

, 14(11): 1325 - 1338

Albert P. Li


DOI: 10.2174/1568026614666140506114411




Ritonavir Analogues as a Probe for Deciphering the Cytochrome P450 3A4 Inhibitory Mechanism

, 14(11): 1348 - 1355

Irina F. Sevrioukova and Thomas L. Poulos


DOI: 10.2174/1568026614666140506120647



Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays

, 14(11): 1356 - 1364

Yen Sia Low, Alexander Yeugenyevich Sedykh, Ivan Rusyn and Alexander Tropsha


DOI: 10.2174/1568026614666140506121116



Prediction of Cytochrome P450 Mediated Metabolism of Designer Drugs

, 14(11): 1365 - 1373

Line Marie Nielsen, Kristian Linnet, Lars Olsen and Patrik Rydberg


DOI: 10.2174/1568026614666140506122202



Mutagenicity of N-oxide Containing Heterocycles and Related Compounds: Experimental and Theoretical Studies

, 14(11): 1374 - 1387

Martin Gabay, Mauricio Cabrera, Rossanna Di Maio, Juan A. Paez, Nuria Campillo, Maria L. Lavaggi, Hugo Cerecetto and Mercedes González


DOI: 10.2174/1568026614666140506123235



In Vitro Microsomal Hepatic Metabolism of Antiasthmatic Prototype LASSBio-448

, 14(11): 1388 - 1398

Isabelle Karine Costa Nunes, Luzineide Wanderley Tinoco, Helvecio Martins-Junior, Claudia Rezende, Eliezer J. Barreiro and Lidia Moreira Lima


DOI: 10.2174/1568026614666140506123718



Tuning hERG Out: Antitarget QSAR Models for Drug Development

, 14(11): 1399 - 1415

Rodolpho C. Braga, Vinicius M. Alves, Meryck F.B. Silva, Eugene Muratov, Denis Fourches, Alexander Tropsha and Carolina H. Andrade


DOI: 10.2174/1568026614666140506124442





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