Contents

Current Topics in Medicinal Chemistry, Volume 13 - Number 18

Editorial (Thematic Issue: The Medicinal Chemistry of the Cytochrome P450s)

, 13(18): 2217

Matthew Sykes


DOI: 10.2174/15680266113136660154




Overview on Theoretical Studies Discriminating the Two-Oxidant Versus Two-State-Reactivity Models for Substrate Monoxygenation by Cytochrome P450 Enzymes

, 13(18): 2218 - 2232

Sam P. de Visser, Cristina S. Porro, Matthew G. Quesne, Mala A. Sainna and Andrew W. Munro


DOI: 10.2174/15680266113136660155




Generation, Validation, and Application of a P450 Homology Model

, 13(18): 2233 - 2240

Benjamin C. Lewis and John O. Miners


DOI: 10.2174/15680266113136660156




Cytochrome P450 2C8 and Drug Metabolism

, 13(18): 2241 - 2253

Xiaoping Lv, Fangfang Zhong and Xiangshi Tan


DOI: 10.2174/15680266113136660157




The Evolution of Cytochrome P450 Enzymes as Biocatalysts in Drug Discovery and Development

, 13(18): 2254 - 2280

Elizabeth M.J. Gillam and Martin A. Hayes


DOI: 10.2174/15680266113136660158




Editorial (Thematic Issue: New Therapeutic Bearings for Repositioned Drugs)

, 13(18): 2281 - 2282

Kevin B. Clark


DOI: 10.2174/15680266113136660159




Minocycline Repurposing in Critical Illness: Focus on Stroke

, 13(18): 2283 - 2290

T. Vivian Liao, Christy C. Forehand, David C. Hess and Susan C. Fagan


DOI: 10.2174/15680266113136660160




Calcium Antagonists: A Ready Prescription for Treating Infectious Diseases?

, 13(18): 2291 - 2305

Kevin B. Clark, Edward M. Eisenstein and Scott E. Krahl


DOI: 10.2174/15680266113136660161




Discovering New Treatments for Alzheimer's Disease by Repurposing Approved Medications

, 13(18): 2306 - 2327

Brian S. Appleby and Jeffrey L. Cummings


DOI: 10.2174/15680266113136660162




Drug Repurposing: Translational Pharmacology, Chemistry, Computers and the Clinic

, 13(18): 2328 - 2336

Naiem T. Issa, Stephen W. Byers and Sivanesan Dakshanamurthy


DOI: 10.2174/15680266113136660163




Drug Repositioning for Treatment of Movement Disorders: From Serendipity to Rational Discovery Strategies

, 13(18): 2337 - 2363

Bence Bolgár, Ádám Arany, Gergely Temesi, Balázs Balogh, Péter Antal and Péter Mátyus


DOI: 10.2174/15680266113136660164




Repurposed Drugs for the Treatment of Schizophrenia and Bipolar Disorders

, 13(18): 2364 - 2385

J. M. Bumb, F. Enning and F. M. Leweke


DOI: 10.2174/15680266113136660165




Repurposed Drugs in Metabolic Disorders

, 13(18): 2386 - 2394

Josef Finsterer and Marlies Frank


DOI: 10.2174/15680266113136660166




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