Contents

Current Topics in Medicinal Chemistry, Volume 13 - Number 12

Editorial (Hot Topic: Cytochrome P450s: New Insights and Relevance to Medicinal Chemistry and Drug Discovery)

, 13(12): 1363

Rheem A. Totah


DOI: 10.2174/1568026611313120001




CYP17A1: A Biochemistry, Chemistry, and Clinical Review

, 13(12): 1364 - 1384

David Porubek


DOI: 10.2174/1568026611313120002




Progress Towards Clinically Useful Aldosterone Synthase Inhibitors

, 13(12): 1385 - 1401

Matthew A. Cerny


DOI: 10.2174/1568026611313120003




Therapeutic Potential of the Inhibition of the Retinoic Acid Hydroxylases CYP26A1 and CYP26B1 by Xenobiotics

, 13(12): 1402 - 1428

Cara H. Nelson, Brian R. Buttrick and Nina Isoherranen


DOI: 10.2174/1568026611313120004




CYP4 Enzymes As Potential Drug Targets: Focus on Enzyme Multiplicity, Inducers and Inhibitors, and Therapeutic Modulation of 20- Hydroxyeicosatetraenoic Acid (20-HETE) Synthase and Fatty Acid ω- Hydroxylase Activities

, 13(12): 1429 - 1440

Katheryne Z. Edson and Allan E. Rettie


DOI: 10.2174/15680266113139990110




Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets

, 13(12): 1441 - 1453

Brianne S. Raccor and Rudiger Kaspera


DOI: 10.2174/1568026611313120006




CYP Epoxygenase Derived EETs: From Cardiovascular Protection to Human Cancer Therapy

, 13(12): 1454 - 1469

Chen Chen and Dao Wen Wang


DOI: 10.2174/1568026611313120007




Cytochrome P450 Bioreactors in the Pharmaceutical Industry: Challenges and Opportunities

, 13(12): 1470 - 1490

Carlos A. Martinez and Sanjeewa G. Rupasinghe


DOI: 10.2174/15680266113139990111




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