Contents

Current Topics in Medicinal Chemistry, Volume 12 - Number 22

Editorial

Editorial (Hot Topic: Protein Misfolding in Conformational Disorders)

, 12(22): 2459

Claudio M. Gomes


DOI: 10.2174/1568026611212220001




Protein Misfolding in Disease and Small Molecule Therapies

, 12(22): 2460 - 2469

Claudio M. Gomes


DOI: 10.2174/1568026611212220002




Aggregation Prone Regions and Gatekeeping Residues in Protein Sequences

, 12(22): 2470 - 2478

Jacinte Beerten, Joost Schymkowitz and Frederic Rousseau


DOI: 10.2174/1568026611212220003




DNAJ Proteins and Protein Aggregation Diseases

, 12(22): 2479 - 2490

Vaishali Kakkar, Louis C. B. Prins and Harm H. Kampinga


DOI: 10.2174/1568026611212220004




Molecular Chaperone Disorders: Defective Hsp60 in Neurodegeneration

, 12(22): 2491 - 2503

Peter Bross, Raffaella Magnoni and Anne Sigaard Bie


DOI: 10.2174/1568026611212220005




On the Design of Broad Based Screening Assays to Identify Potential Pharmacological Chaperones of Protein Misfolding Diseases

, 12(22): 2504 - 2522

Subhashchandra Naik, Na Zhang, Phillip Gao and Mark T. Fisher


DOI: 10.2174/1568026611212220006




Amyloid Formation in Light Chain Amyloidosis

, 12(22): 2523 - 2533

Marina Ramirez-Alvarado


DOI: 10.2174/1568026611212220007




Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones

, 12(22): 2534 - 2545

Jarl Underhaug, Oscar Aubi and Aurora Martinez


DOI: 10.2174/1568026611212220008




Cofactors and Metabolites as Protein Folding Helpers in Metabolic Diseases

, 12(22): 2546 - 2559

Joao V. Rodrigues, Barbara J. Henriques, Tania G. Lucas and Claudio M. Gomes


DOI: 10.2174/1568026611212220009




SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status

, 12(22): 2560 - 2572

Yuewei Sheng, Madhuri Chattopadhyay, Julian Whitelegge and Joan Selverstone Valentine


DOI: 10.2174/1568026611212220010




Copper and Heme-Mediated Abeta Toxicity: Redox Chemistry, Abeta Oxidations and Anti-ROS Compounds

, 12(22): 2573 - 2595

Stefan Chassaing, Fabrice Collin, Pierre Dorlet, Jerome Gout, Christelle Hureau and Peter Faller


DOI: 10.2174/1568026611212220011




Insights into Aβ Aggregation: A Molecular Dynamics Perspective

, 12(22): 2596 - 2610

Joan-Emma Shea and Brigita Urbanc


DOI: 10.2174/1568026611212220012




Putting Huntingtin “Aggregation” in View with Windows into the Cellular Milieu

, 12(22): 2611 - 2622

Danny M. Hatters


DOI: 10.2174/1568026611212220013




Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation

, 12(22): 2623 - 2640

Barbara Calamini and Richard I. Morimoto


DOI: 10.2174/1568026611212220014




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