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Current Topics in Medicinal Chemistry, Volume 12 - Number 19


Docking, Synthesis and Anti-Diabetic Activity of Novel Sulfonylhydrazone Derivatives Designed as PPAR-Gamma Agonists

, 12(19): 2037 - 2048

Gisele Zapata-Sudo, Lidia M. Lima, Sharlene L. Pereira, Margarete M. Trachez, Filipe P. da Costa, Beatriz J. Souza, Carlos E. S. Monteiro, Nelilma C. Romeiro, Everton D. D’Andrea, Roberto T. Sudo and Eliezer J. Barreiro


DOI: 10.2174/1568026611212190002


Acylhydrazones Contribute to Serum Glucose Homeostasis Through Dual Physiological Targets

, 12(19): 2049 - 2058

Marisa Jadna Silva Frederico, Allisson Jhonatan Gomes Castro, Alessandra Mascarello, Camila Pires Mendes, Virginia Dermachi Kappel, Taisa Regina Stumpf, Paulo Cesar Leal, Ricardo Jose Nunes, Rosendo Augusto Yunes and Fatima Regina Mena Barreto Silva


DOI: 10.2174/1568026611212190003




Equinatoxin II Potentiates Temozolomide- and Etoposide-Induced Glioblastoma Cell Death

, 12(19): 2082 - 2093

Suzana Assad Kahn, Deborah Biasoli, Celina Garcia, Luiz Henrique M. Geraldo, Bruno Pontes, Morgana Sobrinho, Ana Carina Bon Frauches, Luciana Romao, Rossana C. Soletti, Fernando dos Santos Assuncao, Fernanda Tovar-Moll, Jorge Marcondes de Souza, Flavia R.S. Lima, Gregor Anderluh and Vivaldo Moura-Neto


DOI: 10.2174/1568026611212190006


Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function

, 12(19): 2094 - 2102

David Rios, Julio Benites, Jaime A. Valderrama, Mirelle Farias, Rozangela C. Pedrosa, Julien Verrax and Pedro Buc Calderon


DOI: 10.2174/1568026611212190007


Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling

, 12(19): 2103 - 2113

Nathalia G. Amado, Barbara F. Fonseca, Debora Malta Cerqueira, Alice H. Reis, Alessandro Bolis Costa Simas, Ricardo Machado Kuster, Fabio A. Mendes and Jose G. Abreu


DOI: 10.2174/1568026611212190008



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